iPTMnet Report for P20701 (ITGAL)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P20701 / ITAL_HUMAN
Protein Name Integrin alpha-L precursor
Gene Name Name: ITGAL
Synonyms:CD11A;
Organism Homo sapiens (Human)

PRO ID PR:P20701
DAG View
PRO Name integrin alpha-L (human)
Definition An integrin alpha-L that is encoded in the genome of human.
Short Label hITGAL
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P20701 (ITGAL) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S37 Phosphorylation PhosphoSitePlus
N65 N-Glycosylation GlyGen 24190977
N89 N-Glycosylation GlyGen 29741879
K180 Ubiquitination PhosphoSitePlus
S187 Phosphorylation PhosphoSitePlus
N188 N-Glycosylation GlyGen   UniProt 19349973
K213 Ubiquitination PhosphoSitePlus
K215 Ubiquitination PhosphoSitePlus
K222 Ubiquitination PhosphoSitePlus
K277 Ubiquitination PhosphoSitePlus
K293 Ubiquitination PhosphoSitePlus
K301 Ubiquitination PhosphoSitePlus
K305 Ubiquitination PhosphoSitePlus
K312 Ubiquitination PhosphoSitePlus
K319 Ubiquitination PhosphoSitePlus
K321 Ubiquitination PhosphoSitePlus
K329 Ubiquitination PhosphoSitePlus
Y332 Phosphorylation PhosphoSitePlus
S338 Phosphorylation PhosphoSitePlus
S355 Phosphorylation PhosphoSitePlus
K371 Ubiquitination PhosphoSitePlus
K416 Ubiquitination PhosphoSitePlus
N670 N-Glycosylation GlyGen 24190977
C717 Methylation IEDB 31844290
K769 Acetylation PhosphoSitePlus
K769 Ubiquitination PhosphoSitePlus
K775 Ubiquitination PhosphoSitePlus
K776 Acetylation PhosphoSitePlus
K776 Ubiquitination PhosphoSitePlus
K831 Ubiquitination PhosphoSitePlus
K836 Ubiquitination PhosphoSitePlus
S839 Phosphorylation PhosphoSitePlus
N862 N-Glycosylation GlyGen 24190977
K945 Ubiquitination PhosphoSitePlus
K950 Ubiquitination PhosphoSitePlus
C1013 Methylation IEDB 31844290
S1140 Phosphorylation PhosphoSitePlus   RLIMS-P 16301335
S1163 Phosphorylation PhosphoSitePlus
S1165 Phosphorylation PhosphoSitePlus   UniProt 16301335
Site PTM Type PTM Enzyme Score Source PMID
K664 Ubiquitination PhosphoSitePlus


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation P21333 (FLNA) S2152 P20701 (ITGAL) increased_association eFIP 30568657


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
N89 K89 Biomuta DOID:3571 / liver cancer [ cosmic ]
K371 N371 Biomuta DOID:363 / uterine cancer [ icgc ] DOID:9256 / colorectal cancer [ cosmic ]
K416 E416 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
K664 N664 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:1324 / lung cancer [ cosmic, icgc ]
K769 N769 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K831 N831 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
N862 D862 Biomuta DOID:363 / uterine cancer [ icgc ]