Protein Information

Cytoscape View

UniProt AC / UniProt ID P20671 / H2A1D_HUMAN
Protein Name Histone H2A type 1-D
Gene Name Name: H2AC7
Organism Homo sapiens (Human)

PRO ID PR:P20671
DAG View
PRO Name histone H2A type 1-D (human)
Definition A histone H2A type 1-D that is encoded in the genome of human.
Short Label hH2AC7
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species

P20671 (H2AC7) as Substrate

Site PTM Type PTM Enzyme Score Source PMID
Acetylation PRO
S2 Acetylation UniProt 15823041, 16457589
S2 Phosphorylation PRO   PhosphoSitePlus 15010469
K6 Acetylation PRO   PhosphoSitePlus 17709392
K6 Methylation PhosphoSitePlus
K10 Acetylation PRO   PhosphoSitePlus 18552846, 12937907
K14 Acetylation PhosphoSitePlus
K14 Ubiquitination UniProt 22713238, 22980979
K16 Ubiquitination UniProt 22713238, 22980979
R21 Methylation PhosphoSitePlus
R30 Methylation PhosphoSitePlus
R82 Methylation PhosphoSitePlus
R89 Methylation PhosphoSitePlus
K96 Acetylation PhosphoSitePlus
K96 Methylation PhosphoSitePlus
K96 Ubiquitination PhosphoSitePlus
K100 Ubiquitination PhosphoSitePlus
T102 Phosphorylation PhosphoSitePlus
Q105 Methylation UniProt 24352239
K119 Acetylation PhosphoSitePlus
K119 Sumoylation PhosphoSitePlus
K119 Ubiquitination PhosphoSitePlus
K120 Sumoylation PhosphoSitePlus
K120 Ubiquitination PRO   PhosphoSitePlus   UniProt 18400894, 25470042, 16359901, ...15386022, 16702407
T121 Phosphorylation PRO   PhosphoSitePlus   UniProt 19965387, 24140421, 15078818
S123 Phosphorylation PhosphoSitePlus
K126 Acetylation PhosphoSitePlus
K126 Ubiquitination PhosphoSitePlus


PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000044937 (hHIST1H2AD/InitMet-/Ac:1) acK6 PRO 17709392
PR:000044938 (hHIST1H2AD/InitMet-/Ubiq:1) ubK120 PRO 15386022, 18400894
PR:000044939 (hHIST1H2AD/InitMet-/Phos:1) pS2 PRO 15010469
PR:000044941 (hHIST1H2AD/InitMet-/Ac:2) acK10 PRO 12937907, 18552846
PR:000044946 (hHIST1H2AD/InitMet-/Phos:2) pT121 PRO 19965387
PR:000047732 (hHIST1H2AD/InitMet-/N6AcLys+) ac PRO

PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
R30 H30 Biomuta DOID:1115 / sarcoma [ tcga ]
R82 * Biomuta DOID:10534 / stomach cancer [ tcga ]
R82 Q82 Biomuta DOID:11054 / urinary bladder cancer [ tcga ]
Q105 E105 Biomuta DOID:2531 / hematologic cancer [ icgc ]
K120 N120 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc, tcga ] DOID:1324 / lung cancer [ cosmic ]
S123 R123 Biomuta DOID:263 / kidney cancer [ tcga ]