Protein Information

Cytoscape View


UniProt AC / UniProt ID P20594 / ANPRB_HUMAN
Protein Name Atrial natriuretic peptide receptor 2 precursor
Gene Name Name: NPR2
Synonyms:ANPRB;
Organism Homo sapiens (Human)

PRO ID PR:P20594
DAG View
PRO Name atrial natriuretic peptide receptor 2 (human)
Definition An atrial natriuretic peptide receptor 2 that is encoded in the genome of human.
Short Label hNPR2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P20594 (NPR2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
T163 Phosphorylation PhosphoSitePlus
Y250 Phosphorylation PhosphoSitePlus
S473 Phosphorylation RLIMS-P 22590601
S489 Phosphorylation RLIMS-P 22590601
S513 Phosphorylation PhosphoSitePlus   UniProt 20977274
T516 Phosphorylation PhosphoSitePlus   UniProt 20977274
S518 Phosphorylation PhosphoSitePlus   RLIMS-P   UniProt 20977274, 22590601
S523 Phosphorylation PhosphoSitePlus   RLIMS-P   UniProt 20977274, 22590601, 23586811
S526 Phosphorylation PhosphoSitePlus   RLIMS-P   UniProt 20977274, 23586811
T529 Phosphorylation PhosphoSitePlus   UniProt 20977274
T561 Phosphorylation PhosphoSitePlus
Y747 Phosphorylation PhosphoSitePlus
K791 Ubiquitination PhosphoSitePlus
Y808 Phosphorylation PhosphoSitePlus
T820 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S513 Phosphorylation HPRD 9624142
T516 Phosphorylation HPRD 9624142
S518 Phosphorylation HPRD 9624142
S523 Phosphorylation HPRD 9624142
S526 Phosphorylation HPRD 9624142


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S489 T489 Biomuta DOID:263 / kidney cancer [ cosmic ]
S518 L518 Biomuta DOID:1909 / melanoma [ icgc, tcga ]
S526 A526 Biomuta DOID:3571 / liver cancer [ icgc ]