iPTMnet Report P20594 NPR2

Protein Information

Cytoscape View

UniProt AC / UniProt ID	P20594 / ANPRB_HUMAN
Protein Name	Atrial natriuretic peptide receptor 2 precursor
Gene Name	Name: NPR2 Synonyms:ANPRB;
Organism	Homo sapiens (Human)

PRO ID	PR:P20594 DAG View
PRO Name	atrial natriuretic peptide receptor 2 (human)
Definition	An atrial natriuretic peptide receptor 2 that is encoded in the genome of human.
Short Label	hNPR2
Category	organism-gene

Interactive Sequence View

	Select/align proteoforms across species

P20594 (NPR2) as Substrate

Expanded View

	Site	PTM Type	PTM Enzyme	Score	Source	PMID
	T163	Phosphorylation		score1	PhosphoSitePlus
	Y250	Phosphorylation		score1	PhosphoSitePlus
	S473	Phosphorylation		score0	RLIMS-P	22590601
	S489	Phosphorylation		score0	RLIMS-P	22590601
	S513	Phosphorylation		score3	PhosphoSitePlus UniProt	20977274
	T516	Phosphorylation		score3	PhosphoSitePlus UniProt	20977274
	S518	Phosphorylation		score4	PhosphoSitePlus RLIMS-P UniProt	20977274, 22590601
	S523	Phosphorylation		score4	PhosphoSitePlus RLIMS-P UniProt	20977274, 22590601, 23586811
	S526	Phosphorylation		score4	PhosphoSitePlus RLIMS-P UniProt	20977274, 23586811
	T529	Phosphorylation		score3	PhosphoSitePlus UniProt	20977274
	T561	Phosphorylation		score1	PhosphoSitePlus
	Y747	Phosphorylation		score1	PhosphoSitePlus
	K791	Ubiquitination		score1	PhosphoSitePlus
	Y808	Phosphorylation		score1	PhosphoSitePlus
	T820	Phosphorylation		score1	PhosphoSitePlus

	Site	PTM Type	PTM Enzyme	Score	Source	PMID
	S513	Phosphorylation		score1	HPRD	9624142
	T516	Phosphorylation		score1	HPRD	9624142
	S518	Phosphorylation		score1	HPRD	9624142
	S523	Phosphorylation		score1	HPRD	9624142
	S526	Phosphorylation		score1	HPRD	9624142

PTM sites affected in variants

Site	Variant	Source	PMID	Disease [Sample source]
S489	T489	Biomuta		DOID:263 / kidney cancer [ cosmic ]
S518	L518	Biomuta		DOID:4159 / skin cancer [ cosmic, icgc ]
S526	L526	Biomuta		DOID:9256 / colorectal cancer [ cosmic ]