Protein Information

Cytoscape View


UniProt AC / UniProt ID P20393 / NR1D1_HUMAN
Protein Name Nuclear receptor subfamily 1 group D member 1
Gene Name Name: NR1D1
Synonyms:EAR1,HREV,THRAL;
Organism Homo sapiens (Human)

PRO ID PR:P20393
DAG View
PRO Name nuclear receptor subfamily 1 group D member 1 (human)
Definition A nuclear receptor subfamily 1 group D member 1 that is encoded in the genome of human.
Short Label hNR1D1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P20393 (NR1D1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S23 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 15302935
S55 Phosphorylation P49841 (GSK3B) PhosphoSitePlus   Signor   UniProt 16484495, 23398316
S59 Phosphorylation P49841 (GSK3B) PhosphoSitePlus   Signor   UniProt 16484495, 23398316
S84 Phosphorylation PhosphoSitePlus
S85 Phosphorylation PhosphoSitePlus
S86 Phosphorylation PhosphoSitePlus
S87 Phosphorylation PhosphoSitePlus
K117 Ubiquitination PhosphoSitePlus
K167 Ubiquitination PhosphoSitePlus
K306 Ubiquitination PhosphoSitePlus
S320 Phosphorylation PhosphoSitePlus
Y394 Phosphorylation PhosphoSitePlus
K400 Acetylation UniProt 24415752
K400 Ubiquitination PhosphoSitePlus
K455 Ubiquitination PhosphoSitePlus
S486 Phosphorylation PhosphoSitePlus
K576 Ubiquitination PhosphoSitePlus
K587 Ubiquitination PhosphoSitePlus
K591 Acetylation UniProt 24415752
K591 Ubiquitination PhosphoSitePlus
K605 Ubiquitination PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S23 P23 Biomuta DOID:1612 / breast cancer [ icgc ]
S55 Y55 Biomuta DOID:363 / uterine cancer [ tcga ]
S84 L84 Biomuta DOID:4362 / cervical cancer [ cosmic, icgc, tcga ]
S84 * Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc, tcga ]
S87 L87 Biomuta DOID:9256 / colorectal cancer [ tcga ]