iPTMnet Report for P20138 (CD33)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P20138 / CD33_HUMAN
Protein Name Myeloid cell surface antigen CD33 precursor
Gene Name Name: CD33
Synonyms:SIGLEC3;
Organism Homo sapiens (Human)

PRO ID PR:P20138
DAG View
PRO Name myeloid cell surface antigen CD33 (human)
Definition A CD33 molecule that is encoded in the genome of human.
Short Label hCD33
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P20138 (CD33) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
T42 Phosphorylation IEDB 32357974
K77 Ubiquitination PhosphoSitePlus
N99 N-Glycosylation GlyGen 24190977
N100 N-Glycosylation GlyGen   UniProt 8702538, 24190977
N113 N-Glycosylation GlyGen 24190977
N209 N-Glycosylation GlyGen 24190977
T226 Phosphorylation PhosphoSitePlus
T239 O-Glycosylation GlyGen 30459171
T239 Phosphorylation PhosphoSitePlus
T240 O-Glycosylation GlyGen 30459171
S248 Phosphorylation PhosphoSitePlus
K250 Ubiquitination PhosphoSitePlus
T299 Phosphorylation PhosphoSitePlus
T302 Phosphorylation PhosphoSitePlus
S307 Phosphorylation PhosphoSitePlus
Y340 Phosphorylation P12931 (SRC) , P06239 (LCK) IntAct   phospho.ELM   PhosphoSitePlus   Signor   UniProt 10206955, 10887109, 10556798
Y358 Phosphorylation IntAct   phospho.ELM   PhosphoSitePlus   UniProt 10206955, 10887109, 10556798
T363 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
Y340 Phosphorylation P12931 (SRC) HPRD 10206955


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T42 P42 Biomuta DOID:4159 / skin cancer [ cosmic ]
N99 S99 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
N99 I99 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
N209 Y209 Biomuta DOID:3571 / liver cancer [ cosmic ]
T226 I226 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S248 L248 Biomuta DOID:4159 / skin cancer [ cosmic ]
T299 N299 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
T299 A299 Biomuta DOID:9256 / colorectal cancer [ cosmic ]