Protein Information

Cytoscape View

UniProt AC / UniProt ID P19838 / NFKB1_HUMAN
Protein Name Nuclear factor NF-kappa-B p105 subunit
Gene Name Name: NFKB1
Organism Homo sapiens (Human)

PRO ID PR:P19838
DAG View
PRO Name nuclear factor NF-kappa-B p105 subunit (human)
Definition A nuclear factor NF-kappa-B p105 subunit that is encoded in the genome of human.
Short Label hNFKB1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species

P19838 (NFKB1) as Substrate

Site PTM Type PTM Enzyme Score Source PMID
S20 Phosphorylation P78527 (PRKDC) neXtProt   PhosphoSitePlus   RLIMS-P 20966071
Y59 Phosphorylation PhosphoSitePlus
C61 S-Nitrosylation dbSNO 1508666, 23796488, 15688001, ...8710491, 22178444, 16099468
S65 Phosphorylation RLIMS-P 29873020
S73 Phosphorylation PhosphoSitePlus
K148 Ubiquitination PhosphoSitePlus
Y165 Phosphorylation PhosphoSitePlus
S223 Phosphorylation PhosphoSitePlus   RLIMS-P 29873020
S226 Phosphorylation RLIMS-P 29873020
T228 Phosphorylation PhosphoSitePlus
S236 Phosphorylation RLIMS-P 29873020
Y240 Phosphorylation PhosphoSitePlus
S242 Phosphorylation PhosphoSitePlus
K243 Ubiquitination PhosphoSitePlus
S248 Phosphorylation RLIMS-P 29873020
K251 Ubiquitination PhosphoSitePlus
T263 Phosphorylation RLIMS-P 29873020
S301 Phosphorylation PhosphoSitePlus
T324 Phosphorylation PhosphoSitePlus
K325 Sumoylation PhosphoSitePlus
S328 Phosphorylation O14757 (CHEK1) PhosphoSitePlus   RLIMS-P   Signor 22152481, 29873020
S337 Phosphorylation P17612 (PRKACA) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor 17959673, 12947093, 26646749, ...15642694, 26872379, 29873020
K345 Ubiquitination PhosphoSitePlus
Y409 Phosphorylation PhosphoSitePlus
T413 Phosphorylation PhosphoSitePlus
K431 Acetylation PhosphoSitePlus   UniProt 11739381
K440 Acetylation PhosphoSitePlus   UniProt 11739381
K440 Ubiquitination PhosphoSitePlus
K441 Acetylation PhosphoSitePlus   UniProt 11739381
K441 Ubiquitination PhosphoSitePlus
S449 Phosphorylation PhosphoSitePlus
Y485 Phosphorylation PhosphoSitePlus
K504 Ubiquitination PhosphoSitePlus
Y582 Phosphorylation PhosphoSitePlus
T584 Phosphorylation PhosphoSitePlus
K624 Ubiquitination PhosphoSitePlus
K816 Ubiquitination PhosphoSitePlus
K821 Ubiquitination PhosphoSitePlus
K830 Ubiquitination PhosphoSitePlus
S851 Phosphorylation PhosphoSitePlus
S855 Phosphorylation PhosphoSitePlus
K856 Ubiquitination PhosphoSitePlus
T882 Phosphorylation PhosphoSitePlus
S892 Phosphorylation PhosphoSitePlus   UniProt 24275569
S893 Phosphorylation phospho.ELM   PhosphoSitePlus 8522173
T897 Phosphorylation PhosphoSitePlus
S899 Phosphorylation PhosphoSitePlus
S903 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 12871932, 23186163
S907 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 23186163, 18220336, 18669648, ...12871932, 26400473
S910 Phosphorylation PhosphoSitePlus
T911 Phosphorylation PhosphoSitePlus
S923 Phosphorylation O15111 (CHUK) , O14920 (IKBKB) phospho.ELM   PhosphoSitePlus   Signor 10469655, 11158290
S927 Phosphorylation O15111 (CHUK) , O14920 (IKBKB) neXtProt   phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P   Signor   UniProt 12482991, 10469655, 11158290, ...10022904, 11976329, 11297557
T931 Phosphorylation O15111 (CHUK) Signor 10469655
S932 Phosphorylation O14920 (IKBKB) , O15111 (CHUK) PRO   PhosphoSitePlus   RLIMS-P   Signor   UniProt 12482991, 10469655, 11158290
S937 Phosphorylation PhosphoSitePlus   UniProt 19690332
T939 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S941 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
Site PTM Type PTM Enzyme Score Source PMID
S338 Phosphorylation P17612 (PRKACA) HPRD 12947093
S852 Phosphorylation HPRD 20068231
S894 Phosphorylation HPRD 17322306
S900 Phosphorylation P49841 (GSK3B) HPRD 11425860
S904 Phosphorylation P49841 (GSK3B) HPRD 18669648, 11425860
S908 Phosphorylation P49841 (GSK3B) HPRD 18669648, 11425860
S922 Phosphorylation O15111 (CHUK) HPRD 10469655
S924 Phosphorylation O14920 (IKBKB) , O15111 (CHUK) HPRD 10469655, 11158290
S928 Phosphorylation O14920 (IKBKB) , O15111 (CHUK) HPRD 11976329
T932 Phosphorylation O15111 (CHUK) HPRD 10469655
S933 Phosphorylation O15111 (CHUK) HPRD 10469655
T940 Phosphorylation HPRD 18669648
S942 Phosphorylation HPRD 18669648
T944 Phosphorylation HPRD 20068231


PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000048595 (hNFKB1/Phos:2) pS927,pS932 PRO

PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation P07900 (HSP90AA1) Y197 P19838 (NFKB1) inhibited_association eFIP 22727666
Phosphorylation P19838 (NFKB1) S932 Q9Y297 (BTRC) unknown eFIP 12482991
Phosphorylation P25963 (NFKBIA) S36 P19838 (NFKB1) unknown eFIP 15128824
Phosphorylation Q9GZV1 (ANKRD2) S99 P19838 (NFKB1) unknown eFIP 24434510

PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
Y59 F59 Biomuta DOID:2531 / hematologic cancer [ tcga ]
S73 C73 Biomuta DOID:1612 / breast cancer [ tcga ]
S223 I223 Biomuta DOID:363 / uterine cancer [ tcga ]
S226 R226 Biomuta DOID:363 / uterine cancer [ tcga ]
T413 I413 Biomuta DOID:363 / uterine cancer [ tcga ]
S449 R449 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc, tcga ]
T584 M584 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
T882 I882 Biomuta DOID:3070 / malignant glioma [ tcga ] DOID:11054 / urinary bladder cancer [ cosmic, icgc, tcga ]
S892 P892 Biomuta DOID:3963 / thyroid carcinoma [ cosmic, icgc ]
S903 L903 Biomuta DOID:9256 / colorectal cancer [ tcga ]
S907 L907 Biomuta DOID:1909 / melanoma [ icgc, tcga ]
S910 F910 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S932 F932 Biomuta DOID:9256 / colorectal cancer [ tcga ]