iPTMnet Report for P19827 (ITIH1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P19827 / ITIH1_HUMAN
Protein Name Inter-alpha-trypsin inhibitor heavy chain H1 precursor
Gene Name Name: ITIH1
Synonyms:IGHEP1;
Organism Homo sapiens (Human)

PRO ID PR:P19827
DAG View
PRO Name inter-alpha-trypsin inhibitor heavy chain H1 (human)
Definition An inter-alpha-trypsin inhibitor heavy chain H1 that is encoded in the genome of human.
Short Label hITIH1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P19827 (ITIH1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
T46 Phosphorylation PhosphoSitePlus
C60 S-Glycosylation GlyGen   UniProt 9425062
S129 Phosphorylation PhosphoSitePlus   UniProt 24275569
N285 N-Glycosylation GlyGen 34725484, 9677337, 23090970, ...29391424, 9425062, 19139490, 24279413, 29741879, 12754519, 29671580
T402 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
T407 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
S414 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
Y431 Phosphorylation PhosphoSitePlus
Y504 Phosphorylation PhosphoSitePlus
S522 Phosphorylation PhosphoSitePlus
N588 N-Glycosylation GlyGen 34725484, 9677337, 23090970, ...14760718, 29391424, 9425062, 29741879, 29671580
T604 O-Glycosylation GlyGen 30459171
T623 O-Glycosylation GlyGen 30459171
T653 O-Glycosylation GlyGen 9677337, 9425062
N750 N-Glycosylation GlyGen   UniProt 19159218
S788 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
N285 N-Glycosylation PRO 9677337, 29671580
T402 Phosphorylation HPRD 18669648
T407 Phosphorylation HPRD 18669648
S414 Phosphorylation HPRD 18669648
Y504 Phosphorylation HPRD 17924679
N588 N-Glycosylation PRO 9677337, 29671580


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S129 L129 Biomuta DOID:11054 / urinary bladder cancer [ cosmic ]
T653 N653 Biomuta DOID:263 / kidney cancer [ cosmic, icgc ]
S788 Y788 Biomuta DOID:363 / uterine cancer [ icgc ]
S788 F788 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]