iPTMnet Report for P19823 (ITIH2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P19823 / ITIH2_HUMAN
Protein Name Inter-alpha-trypsin inhibitor heavy chain H2 precursor
Gene Name Name: ITIH2
Synonyms:IGHEP2;
Organism Homo sapiens (Human)

PRO ID PR:P19823
DAG View
PRO Name inter-alpha-trypsin inhibitor heavy chain H2 (human)
Definition An inter-alpha-trypsin inhibitor heavy chain H2 that is encoded in the genome of human.
Short Label hITIH2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P19823 (ITIH2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S55 Phosphorylation HPRD   PhosphoSitePlus 19562805
S60 Phosphorylation HPRD   PhosphoSitePlus   UniProt 19824718, 19562805, 24275569, ...26091039, 15345747
S117 Phosphorylation PhosphoSitePlus
N118 N-Glycosylation GlyGen 16335952, 9677337, 19159218, ...23090970, 29391424, 9425062, 29741879, 12754519, 29671580
S130 Phosphorylation PhosphoSitePlus
K190 Acetylation PhosphoSitePlus
T267 Phosphorylation PhosphoSitePlus
Y277 Phosphorylation PhosphoSitePlus
N445 N-Glycosylation GlyGen   UniProt 16335952
S466 Phosphorylation UniProt 26091039
K488 Acetylation PhosphoSitePlus
S597 Phosphorylation PhosphoSitePlus
T601 O-Glycosylation GlyGen   PhosphoSitePlus 23584533
T601 Phosphorylation PhosphoSitePlus
S652 O-Glycosylation GlyGen 30459171
S665 O-Glycosylation GlyGen 22171320
T666 O-Glycosylation GlyGen 9677337, 22171320, 9425062
S668 O-Glycosylation GlyGen 22171320
S673 O-Glycosylation GlyGen 26598643, 9677337, 22171320, ...9425062
T675 O-Glycosylation GlyGen 9677337, 30237853, 30459171, ...22171320, 9425062, 26598643
S679 O-Glycosylation GlyGen 22171320
S690 O-Glycosylation GlyGen 30459171
T691 O-Glycosylation GlyGen 7682553, 9677337, 30459171, ...25813380, 9425062, 26598643
N715 N-Glycosylation GlyGen 29391424
S783 Phosphorylation PhosphoSitePlus
T817 Phosphorylation PhosphoSitePlus
S886 Phosphorylation UniProt 26091039
Site PTM Type PTM Enzyme Score Source PMID
N118 N-Glycosylation PRO 9677337, 29671580


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S60 L60 Biomuta [ cosmic ]
S117 C117 Biomuta DOID:4159 / skin cancer [ cosmic ]
N118 S118 Biomuta DOID:4159 / skin cancer [ cosmic ]
S130 I130 Biomuta [ cosmic ] DOID:1115 / sarcoma [ icgc ]
T267 N267 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
T267 S267 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
K488 T488 Biomuta DOID:9256 / colorectal cancer [ icgc ] DOID:3571 / liver cancer [ cosmic ]
S668 Y668 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S668 P668 Biomuta DOID:1324 / lung cancer [ cosmic ]
T675 M675 Biomuta DOID:5041 / esophageal cancer [ cosmic ]
S690 Y690 Biomuta DOID:1324 / lung cancer [ cosmic ]
S783 R783 Biomuta DOID:1324 / lung cancer [ cosmic ]