iPTMnet Report for P19793 (RXRA)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P19793 / RXRA_HUMAN
Protein Name Retinoic acid receptor RXR-alpha
Gene Name Name: RXRA
Synonyms:NR2B1;
Organism Homo sapiens (Human)

PRO ID PR:P19793
DAG View
PRO Name retinoic acid receptor RXR-alpha (human)
Definition A retinoic acid receptor RXR-alpha that is encoded in the genome of human.
Short Label hRXRA
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P19793 (RXRA) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S17 Phosphorylation PhosphoSitePlus
T20 Phosphorylation PhosphoSitePlus
S21 Phosphorylation phospho.ELM   PRO   PhosphoSitePlus 18669648
S27 Phosphorylation P17612 (PRKACA) PhosphoSitePlus   Signor   UniProt 11162439
S32 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P 16184197
S49 Phosphorylation PhosphoSitePlus
S56 Phosphorylation P45983 (MAPK8) , P45984 (MAPK9) neXtProt 10383391
S66 Phosphorylation PhosphoSitePlus
S70 Phosphorylation P45984 (MAPK9) , P45983 (MAPK8) neXtProt 10383391
S78 Phosphorylation PhosphoSitePlus
T82 Phosphorylation P28482 (MAPK1) , P27361 (MAPK3) , P45984 (MAPK9) , P45983 (MAPK8) neXtProt   phospho.ELM   PhosphoSitePlus   Signor 17604322, 10383391, 12048211
S88 Phosphorylation IEDB 32387766
K108 Sumoylation PhosphoSitePlus
S129 Phosphorylation PhosphoSitePlus   UniProt 23186163
K145 Acetylation UniProt 17761950
Y147 Phosphorylation PhosphoSitePlus
Y150 Phosphorylation PhosphoSitePlus
Y249 Phosphorylation P45985 (MAP2K4) phospho.ELM   PhosphoSitePlus   Signor 10938283
S259 Phosphorylation PhosphoSitePlus   UniProt 24275569
S260 Phosphorylation P27361 (MAPK3) , P45984 (MAPK9) , P28482 (MAPK1) , P45983 (MAPK8) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor 11826406, 11606411, 27852823, ...16551633, 12048211, 17604322, 11121228, 10383391, 18003614, 29300860, 10377179
T266 Phosphorylation PhosphoSitePlus
K356 Ubiquitination PhosphoSitePlus
K364 Ubiquitination PhosphoSitePlus
Y397 Phosphorylation PhosphoSitePlus
Y403 Phosphorylation PhosphoSitePlus
K417 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S21 Phosphorylation HPRD 18669648, 20068231
T82 Phosphorylation Q13164 (MAPK7) HPRD 12048211
S260 Phosphorylation Q13164 (MAPK7) , P28482 (MAPK1) HPRD 12048211


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000049146 (hRXRA/Phos:2) pS21 PRO


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation P19793 (RXRA) S260 P11473 (VDR) unknown eFIP 29300860


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S27 C27 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
S49 A49 Biomuta DOID:1612 / breast cancer [ cosmic ]
S78 L78 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
Y150 H150 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
Y249 F249 Biomuta DOID:1319 / brain cancer [ cosmic, icgc ]
S260 L260 Biomuta DOID:1612 / breast cancer [ cosmic ]
S260 * Biomuta DOID:4159 / skin cancer [ cosmic ]
Y397 C397 Biomuta DOID:2394 / ovarian cancer [ cosmic, icgc ] DOID:3571 / liver cancer [ cosmic, icgc ]