Protein Information

Cytoscape View


UniProt AC / UniProt ID P19784 / CSK22_HUMAN
Protein Name Casein kinase II subunit alpha'
Gene Name Name: CSNK2A2
Synonyms:CK2A2;
Organism Homo sapiens (Human)

PRO ID PR:P19784
DAG View
PRO Name casein kinase II subunit alpha' (human)
Definition A casein kinase II subunit alpha' that is encoded in the genome of human.
Short Label hCSNK2A2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P19784 (CSNK2A2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
Y13 Phosphorylation PhosphoSitePlus   UniProt 19369195
S18 Phosphorylation HPRD   PhosphoSitePlus   UniProt 18691976, 23186163, 19369195
S21 Phosphorylation HPRD   PhosphoSitePlus   UniProt 18691976, 19369195
Y24 Phosphorylation PhosphoSitePlus
K50 Acetylation PhosphoSitePlus
K69 Ubiquitination PhosphoSitePlus
K72 Ubiquitination PhosphoSitePlus
K84 Ubiquitination PhosphoSitePlus
R90 Methylation PhosphoSitePlus
K97 Acetylation PhosphoSitePlus   UniProt 19608861
Y116 Phosphorylation PhosphoSitePlus
K159 Ubiquitination PhosphoSitePlus
S195 Phosphorylation PhosphoSitePlus
Y210 Phosphorylation PhosphoSitePlus
Y240 Phosphorylation PhosphoSitePlus
Y256 Phosphorylation phospho.ELM   PhosphoSitePlus 12628006
K260 Ubiquitination PhosphoSitePlus
K261 Ubiquitination PhosphoSitePlus
K280 Ubiquitination PhosphoSitePlus
S288 Phosphorylation HPRD   PhosphoSitePlus   UniProt 18691976, 19369195
K304 Ubiquitination PhosphoSitePlus
K330 Ubiquitination PhosphoSitePlus
S333 Phosphorylation PhosphoSitePlus
C336 S-Nitrosylation dbSNO 26338901
S343 Phosphorylation PhosphoSitePlus
T347 O-Glycosylation GlyGen 20305658, 28657654


P19784 (CSNK2A2) as PTM Enzyme



Substrate Site Score Source PMID
O14958-1 (CASQ2) S385 HPRD 1985907
O43896 (KIF1C) S1092 HPRD 18669648, 20068231, 10559254
O60936 (NOL3) T149 Signor 12191471
P01106-2 (MYC) T73 HPRD 19651622, 2663470, 18669648, ...20068231
P04198 (MYCN) S261 HPRD 1425701
P04198 (MYCN) S263 HPRD 1425701
P04818 (TYMS) S124 PhosphoSitePlus 20199796
P07910-2 (HNRNPC) S247 HPRD 19413330, 18691976, 17287340, ...12564933, 20058876, 19664995, 18452278, 19651622, 18669648, 17693683, 20166139, 20068231
P07910-1 (HNRNPC) S260 HPRD 19413330, 18691976, 17287340, ...12564933, 20058876, 19664995, 18452278, 19651622, 18669648, 17693683, 20166139, 20068231
P08575 (PTPRC) S1001 Signor 10066810
P08575 (PTPRC) S1004 Signor 10066810
P08575 (PTPRC) S1005 Signor 10066810
P08575 (PTPRC) S1009 Signor 10066810
P09497-1 (CLTB) S11 HPRD 2874131, 3128543
P09497-2 (CLTB) S13 HPRD 2874131, 3128543
P10451-5 (SPP1) S148 HPRD 8663267
P11836-1 (MS4A1) S231 HPRD   Signor 7678037
P11836 (MS4A1) T250 HPRD   Signor 7678037
P11836 (MS4A1) S289 HPRD   Signor 7678037
P13349 (MYF5) S49 HPRD 9461343
P13349 (MYF5) S133 HPRD 9461343
P17096-2 (HMGA1) S88 HPRD 18452278, 19651622, 2806554, ...20166139, 19415658, 20068231
P17096-2 (HMGA1) S91 HPRD 19413330, 18491316, 18452278, ...19651622, 20187088, 2806554, 20166139, 19415658, 20068231
P17096-2 (HMGA1) S92 HPRD 19413330, 18491316, 18452278, ...19651622, 20187088, 2806554, 20166139, 19415658, 20068231
P17096-1 (HMGA1) S99 HPRD 18452278, 19651622, 2806554, ...20166139, 19415658, 20068231
P17096-1 (HMGA1) S102 HPRD 19413330, 18491316, 18452278, ...19651622, 20187088, 2806554, 20166139, 19415658, 20068231
P17096-1 (HMGA1) S103 HPRD 19413330, 18491316, 18452278, ...19651622, 20187088, 2806554, 20166139, 19415658, 20068231
P17931 (LGALS3) S6 HPRD 10961987, 8253806
P17931 (LGALS3) S12 HPRD 8253806
P18031 (PTPN1) S352 HPRD 18691976, 9600099, 20068231
P18031 (PTPN1) S378 HPRD 9600099
P18031 (PTPN1) S386 HPRD 9600099, 8491187
P18887 (XRCC1) S485 PhosphoSitePlus 15367657
P18887 (XRCC1) T488 PhosphoSitePlus 15367657
P18887 (XRCC1) S518 HPRD   PhosphoSitePlus   Signor 15367657, 18452278
P18887 (XRCC1) T519 HPRD   PhosphoSitePlus   Signor 15367657, 15066279, 18452278
P18887 (XRCC1) T523 HPRD   PhosphoSitePlus   Signor 15367657, 18452278
P21673 (SAT1) T10 HPRD 8954982
P21673 (SAT1) S146 HPRD 8954982
P21673 (SAT1) S149 HPRD 8954982
P24534 (EEF1B2) S106 HPRD 19413330, 8547318, 18491316, ...17287340, 18212344, 20230923, 15302935, 19664994, 19664995, 18452278, 19651622, 14729942, 18669648, 20058876, 17693683, 20166139, 15345747, 19415658, 20068231
P24534 (EEF1B2) S112 HPRD 19413330, 8547318, 18669648, ...19415658, 20068231
P32121-1 (ARRB2) T382 HPRD 11877451
P35222 (CTNNB1) S29 PhosphoSitePlus 12432063
P35222 (CTNNB1) T102 PhosphoSitePlus 12432063
P35222 (CTNNB1) T112 PhosphoSitePlus 12432063
P37840-1 (SNCA) S129 HPRD 10852916, 10617630
P41236 (PPP1R2) S87 HPRD 18669648, 18491316, 8288648
P41236 (PPP1R2) S121 HPRD 18491316, 18088087, 18212344, ...8288648, 19651622, 20166139, 17287340, 19415658, 20068231
P41236 (PPP1R2) S122 HPRD 18491316, 18088087, 18212344, ...18767875, 8288648, 19651622, 20166139, 17287340, 19415658, 20068231
P42768 (WAS) S483 HPRD   Signor 18088087, 12769847
P42768 (WAS) S484 HPRD   Signor 18088087, 12769847
P49795 (RGS19) S24 HPRD 10993892, 10760275
P51946 (CCNH) T315 PhosphoSitePlus 12140753
P52655-2 (GTF2A1) S241 HPRD 11278496
P52655-2 (GTF2A1) S242 HPRD 11278496
P52655-2 (GTF2A1) S277 HPRD 11278496, 18452278
P52655-1 (GTF2A1) S280 HPRD 11278496
P52655-1 (GTF2A1) S281 HPRD 11278496
P52655-2 (GTF2A1) S282 HPRD 11278496, 18452278
P52655-1 (GTF2A1) S316 HPRD 11278496, 18452278
P52655-1 (GTF2A1) S321 HPRD 11278496, 18452278
P55087-1 (AQP4) S276 HPRD 11742978
P55087-1 (AQP4) S285 HPRD 11742978
P55087-1 (AQP4) S316 HPRD 11742978
P55957-1 (BID) T59 HPRD   Signor 11583622
P55957 (BID) S64 HPRD   Signor 11583622
P60484-1 (PTEN) T366 HPRD 12297295
P60484-1 (PTEN) S370 HPRD 12297295
P67870 (CSNK2B) S2 PhosphoSitePlus 1939094
P67870 (CSNK2B) S3 PhosphoSitePlus 1939094
P84090 (ERH) T18 HPRD 9074495
P84090 (ERH) S24 HPRD 9074495
Q00613 (HSF1) T142 PhosphoSitePlus   Signor 12659875
Q01105-2 (SET) S9 Signor 23374587
Q01892 (SPIB) S37 HPRD   Signor 10618498
Q01892-1 (SPIB) S129 HPRD   Signor 10618498
Q01892 (SPIB) S144 HPRD   Signor 10618498
Q01892-1 (SPIB) S146 HPRD   Signor 10618498
Q03060-16 (CREM) T63 HPRD 8404858
Q03060-16 (CREM) S110 HPRD 8404858
Q03135-1 (CAV1) S88 HPRD 8058322
Q05940-1 (SLC18A2) S511 HPRD 18088087, 9045708
Q12972-2 (PPP1R8) T19 HPRD 9407077
Q12972-2 (PPP1R8) S62 HPRD 9407077
Q12972-1 (PPP1R8) T161 HPRD 9407077
Q12972-1 (PPP1R8) S204 HPRD 9407077
Q13085-1 (ACACA) S29 HPRD 19413330, 18691976, 18212344, ...18767875, 19664994, 19664995, 18452278, 19651622, 18669648, 20166139, 19415658, 20068231, 2900140
Q13085-4 (ACACA) S66 HPRD 19413330, 18691976, 18212344, ...18767875, 19664994, 19664995, 18452278, 19651622, 18669648, 20166139, 19415658, 20068231, 2900140
Q13144 (EIF2B5) S717 HPRD   Signor 11500362, 18669648
Q13144 (EIF2B5) S718 HPRD   Signor 11500362, 18669648
Q13541 (EIF4EBP1) S112 HPRD   Signor 11146653, 9806882, 18212344, ...12588975
Q13547 (HDAC1) S421 HPRD   Signor 19413330, 17287340, 18767875, ...11602581, 18452278, 19651622, 18669648, 20166139, 19415658, 20068231
Q13547 (HDAC1) S423 HPRD   Signor 19413330, 17287340, 18767875, ...11602581, 18452278, 19651622, 18669648, 20166139, 19415658, 20068231
Q14005-3 (IL16) S42 HPRD 12450396
Q14005-1 (IL16) S743 HPRD 12450396
Q16543 (CDC37) S13 HPRD   PhosphoSitePlus 19413330, 12930845, 18566753, ...15082798, 20068231
Q16623-1 (STX1A) S14 HPRD 18510355, 10844023, 9930733
Q6FHW4 (TCF7L2) S58 HPRD 11711551
Q6FHW4 (TCF7L2) S59 HPRD 11711551, 18452278
Q6FHW4 (TCF7L2) S60 HPRD 11711551, 18452278
Q712K3 (UBE2R2) S233 HPRD   Signor 18669648, 12037680
Q92598-1 (HSPH1) S509 HPRD 12558502, 10772927
Q92769 (HDAC2) S394 Signor 12082111
Q92769 (HDAC2) S422 Signor 12082111
Q92769 (HDAC2) S424 Signor 12082111
Q96SB4 (SRPK1) S51 PhosphoSitePlus 12565829
Q96SB4 (SRPK1) S555 PhosphoSitePlus 12565829
Q99801 (NKX3-1) T89 PhosphoSitePlus   Signor 16581776
Q99801 (NKX3-1) T93 PhosphoSitePlus   Signor 16581776
Q9NZU7-2 (CABP1) S120 HPRD 14685260
Q9NZU7-1 (CABP1) S180 HPRD 14685260
Q9UD71-2 (PPP1R1B) S9 HPRD 2557337
Q9UD71-1 (PPP1R1B) S45 HPRD 2557337
Q9UD71-2 (PPP1R1B) S66 HPRD 2557337
Q9UD71-1 (PPP1R1B) S102 HPRD 2557337
Q9UNN4-1 (GTF2A1L) S356 HPRD 12107178
Q9UNN4-1 (GTF2A1L) S357 HPRD 12107178
Q9UNN4-1 (GTF2A1L) S418 HPRD 12107178
Q9UNN4-1 (GTF2A1L) S423 HPRD 12107178
Q9UQE7 (SMC3) S1067 PhosphoSitePlus   Signor 18442975
Q9Y5B0 (CTDP1) S575 HPRD   Signor 12591939
Q9Y5B0-1 (CTDP1) S740 HPRD   Signor 12591939, 18669648, 19664994, ...19664995


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
R90 C90 Biomuta DOID:1909 / melanoma [ icgc, tcga ]
R90 H90 Biomuta DOID:10283 / prostate cancer [ cosmic ]