iPTMnet Report for P19634 (SLC9A1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P19634 / SL9A1_HUMAN
Protein Name Sodium/hydrogen exchanger 1
Gene Name Name: SLC9A1
Synonyms:APNH1,NHE1;
Organism Homo sapiens (Human)

PRO ID PR:P19634
DAG View
PRO Name sodium/hydrogen exchanger 1 (human)
Definition A sodium/hydrogen exchanger 1 that is encoded in the genome of human.
Short Label hSLC9A1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P19634 (SLC9A1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S5 Phosphorylation PhosphoSitePlus
C8 Methylation IEDB 31844290
S11 Phosphorylation PhosphoSitePlus
S18 Phosphorylation PhosphoSitePlus
T42 Phosphorylation PhosphoSitePlus
N75 N-Glycosylation GlyGen   UniProt 8068684
Y96 Phosphorylation PhosphoSitePlus
S158 Phosphorylation PhosphoSitePlus
S338 Phosphorylation IEDB 32387766
S372 Phosphorylation PhosphoSitePlus
K559 Ubiquitination PhosphoSitePlus
K560 Ubiquitination PhosphoSitePlus
Y577 Phosphorylation PhosphoSitePlus
K583 Ubiquitination PhosphoSitePlus
S599 Phosphorylation PhosphoSitePlus   UniProt 24275569
S602 Phosphorylation PhosphoSitePlus   UniProt 23186163, 24275569
T603 Phosphorylation PhosphoSitePlus
S605 Phosphorylation PhosphoSitePlus   UniProt 23186163
K612 Ubiquitination PhosphoSitePlus
S616 Phosphorylation PhosphoSitePlus
S624 Phosphorylation PhosphoSitePlus
K625 Ubiquitination PhosphoSitePlus
S648 Phosphorylation P31749 (AKT1) neXtProt   PhosphoSitePlus   UniProt 18757828, 20026127
T653 Phosphorylation O75116 (ROCK2) , Q13464 (ROCK1) PhosphoSitePlus   RLIMS-P 27555478, 25578862
Y659 Phosphorylation PhosphoSitePlus
Y683 Phosphorylation PhosphoSitePlus
T685 Phosphorylation PhosphoSitePlus
S693 Phosphorylation P28482 (MAPK1) phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 18669648, 23186163, 27083547, ...15253667
T695 Phosphorylation phospho.ELM   PhosphoSitePlus 18088087
S697 O-Glycosylation GlyGen 30379171, 34019948
S697 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
S703 Phosphorylation P31749 (AKT1) , Q15418 (RPS6KA1) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 21406692, 18088087, 20026127, ...25830299, 19765648, 25162926, 27049728, 27266704, 18669648, 22216126, 24275569, 10400637, 18757828, 23186163, 19690332, 20068231
Y708 Phosphorylation PhosphoSitePlus
T718 Phosphorylation Q16539 (MAPK14) neXtProt   phospho.ELM   PhosphoSitePlus   Signor 11604491
S723 Phosphorylation Q16539 (MAPK14) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 18669648, 11604491, 27083547
S726 Phosphorylation Q16539 (MAPK14) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 18701649, 11604491, 18669648, ...27083547
S729 Phosphorylation Q16539 (MAPK14) neXtProt   phospho.ELM   PhosphoSitePlus   Signor   UniProt 18669648, 11604491, 18701649
K738 Ubiquitination PhosphoSitePlus
K750 Ubiquitination PhosphoSitePlus
S766 Phosphorylation PhosphoSitePlus
S770 Phosphorylation P28482 (MAPK1) phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor 17209041, 18669648, 23602949, ...15253667
S771 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P 18669648, 23602949, 27083547, ...25162926
T774 Phosphorylation PhosphoSitePlus
T779 Phosphorylation PhosphoSitePlus   RLIMS-P   UniProt 31375679, 27083547
S783 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S785 Phosphorylation P28482 (MAPK1) phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 18669648, 23186163, 27083547, ...15253667
S787 Phosphorylation phospho.ELM   PhosphoSitePlus 17525332, 18669648
S788 Phosphorylation phospho.ELM   PhosphoSitePlus 17525332, 18669648
S796 Phosphorylation P31749 (AKT1) neXtProt   PhosphoSitePlus 18757828, 20026127
Site PTM Type PTM Enzyme Score Source PMID
Y683 Phosphorylation HPRD 18707149
S693 Phosphorylation P28482 (MAPK1) HPRD 18669648, 20068231, 15253667
T695 Phosphorylation HPRD 18088087
S697 Phosphorylation HPRD 18669648, 20068231
S703 Phosphorylation HPRD 18578522, 18088087, 19664994, ...20058876, 18669648, 20068231
T718 Phosphorylation Q16539 (MAPK14) HPRD 11604491
S723 Phosphorylation Q16539 (MAPK14) HPRD 11604491, 18669648, 20068231
S726 Phosphorylation Q16539 (MAPK14) HPRD 11604491, 18669648, 20068231
S729 Phosphorylation Q16539 (MAPK14) HPRD 11604491, 18669648, 20068231
S766 Phosphorylation P28482 (MAPK1) HPRD 15253667
S770 Phosphorylation P28482 (MAPK1) HPRD 18669648, 15253667
S771 Phosphorylation HPRD 18669648
T779 Phosphorylation P28482 (MAPK1) HPRD 15253667
S783 Phosphorylation HPRD 18669648
S785 Phosphorylation P28482 (MAPK1) HPRD 18088087, 18669648, 20058876, ...19415658, 15253667
S787 Phosphorylation HPRD 18077418, 17525332, 18669648, ...19415658
S788 Phosphorylation HPRD 18077418, 17525332, 18669648


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
N75 H75 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S338 R338 Biomuta DOID:3571 / liver cancer [ cosmic ]
K560 N560 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
K560 R560 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
Y577 C577 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K625 E625 Biomuta DOID:363 / uterine cancer [ cosmic ]
T653 M653 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
T685 M685 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:9256 / colorectal cancer [ cosmic ]
T685 K685 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
S703 L703 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S770 L770 Biomuta DOID:10283 / prostate cancer [ cosmic, icgc ] DOID:10534 / stomach cancer [ cosmic ]
S787 I787 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]