Protein Information

Cytoscape View


UniProt AC / UniProt ID P19532 / TFE3_HUMAN
Protein Name Transcription factor E3
Gene Name Name: TFE3
Synonyms:BHLHE33;
Organism Homo sapiens (Human)

PRO ID PR:P19532
DAG View
PRO Name transcription factor E3 (human)
Definition A transcription factor E3 that is encoded in the genome of human.
Short Label hTFE3
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P19532 (TFE3) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S2 Phosphorylation PhosphoSitePlus
K68 Sumoylation PhosphoSitePlus
T85 Phosphorylation PhosphoSitePlus
S101 Phosphorylation PhosphoSitePlus
S109 Phosphorylation PhosphoSitePlus
S112 Phosphorylation PhosphoSitePlus
R122 Methylation PhosphoSitePlus
S149 Phosphorylation PhosphoSitePlus
K178 Methylation PhosphoSitePlus
K200 Ubiquitination PhosphoSitePlus
Y202 Phosphorylation PhosphoSitePlus
T217 Phosphorylation PhosphoSitePlus
S246 Phosphorylation PhosphoSitePlus   RLIMS-P 32662822
S321 Phosphorylation PhosphoSitePlus   RLIMS-P 30849994, 33420039
K330 Sumoylation PhosphoSitePlus
S334 Phosphorylation PhosphoSitePlus
K339 Ubiquitination PhosphoSitePlus
R365 Methylation PhosphoSitePlus
K385 Ubiquitination PhosphoSitePlus
K401 Acetylation PhosphoSitePlus
S542 Phosphorylation PhosphoSitePlus   UniProt 24275569
S548 Phosphorylation PhosphoSitePlus   UniProt 23186163, 20068231, 24275569
S554 Phosphorylation PhosphoSitePlus
S556 Phosphorylation PhosphoSitePlus   UniProt 21406692, 23186163, 20068231
S560 O-Glycosylation GlyGen 28657654
S560 Phosphorylation PhosphoSitePlus   UniProt 23186163, 17081983, 20068231
S563 Phosphorylation PhosphoSitePlus
S564 Phosphorylation PhosphoSitePlus
S567 Phosphorylation PhosphoSitePlus
S568 Phosphorylation PhosphoSitePlus   UniProt 21406692
S570 Phosphorylation PhosphoSitePlus
S575 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
T217 Phosphorylation HPRD 20068231
T236 Phosphorylation HPRD 20068231
S246 Phosphorylation HPRD 20068231
S257 Phosphorylation HPRD 20068231
S542 Phosphorylation HPRD 20058876
S548 Phosphorylation HPRD 19651622, 20058876, 20068231
S553 Phosphorylation HPRD 17081983
S554 Phosphorylation HPRD 19651622, 17081983, 20068231
S556 Phosphorylation HPRD 19413330, 17081983, 20058876, ...19651622, 19415658, 20068231
S560 Phosphorylation HPRD 19651622, 17081983, 20068231
S568 Phosphorylation HPRD 20068231


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K68 E68 Biomuta DOID:1612 / breast cancer [ cosmic ]
R122 Q122 Biomuta DOID:9256 / colorectal cancer [ icgc ]
S246 G246 Biomuta DOID:3963 / thyroid carcinoma [ cosmic, icgc ]
S321 F321 Biomuta DOID:1324 / lung cancer [ tcga ]
S542 P542 Biomuta DOID:3963 / thyroid carcinoma [ cosmic, icgc ]
S567 R567 Biomuta DOID:1115 / sarcoma [ tcga ]
S568 N568 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc, tcga ]