iPTMnet Report for P19532 (TFE3)
Protein Information
| UniProt AC / UniProt ID | P19532 / TFE3_HUMAN |
| Protein Name | Transcription factor E3 |
| Gene Name | Name: TFE3 Synonyms:BHLHE33; |
| Organism | Homo sapiens (Human) |
| PRO ID | PR:P19532 |
| PRO Name | transcription factor E3 (human) |
| Definition | A transcription factor E3 that is encoded in the genome of human. |
| Short Label | hTFE3 |
| Category | organism-gene |
P19532 (TFE3) as Substrate
| Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
|---|---|---|---|---|---|---|
| S2 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S47 | Phosphorylation | score2 | UniProt | 36608670 | ||
| K68 | Sumoylation | score1 | PhosphoSitePlus | |||
| T85 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S101 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S109 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S112 | Phosphorylation | score1 | PhosphoSitePlus | |||
| R122 | Methylation | score1 | PhosphoSitePlus | |||
| S149 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K178 | Methylation | score1 | PhosphoSitePlus | |||
| K200 | Ubiquitination | score1 | PhosphoSitePlus | |||
| Y202 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T217 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S246 | Phosphorylation | score3 | PhosphoSitePlus RLIMS-P | 32662822 | ||
| S321 | Phosphorylation | score4 | PhosphoSitePlus RLIMS-P UniProt | 24448649, 30849994, 30520728, ... | ||
| K330 | Sumoylation | score1 | PhosphoSitePlus | |||
| S334 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K339 | Ubiquitination | score1 | PhosphoSitePlus | |||
| R365 | Methylation | score1 | PhosphoSitePlus | |||
| K385 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K401 | Acetylation | score1 | PhosphoSitePlus | |||
| S542 | Phosphorylation | score2 | PhosphoSitePlus UniProt | 24275569 | ||
| S548 | Phosphorylation | score2 | PhosphoSitePlus UniProt | 23186163, 20068231, 24275569 | ||
| S554 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S556 | Phosphorylation | score2 | PhosphoSitePlus UniProt | 21406692, 23186163, 20068231 | ||
| S560 | O-Glycosylation | score1 | GlyGen | 34725712, 28657654 | ||
| S560 | Phosphorylation | score2 | PhosphoSitePlus UniProt | 23186163, 17081983, 20068231 | ||
| S563 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S564 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S567 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S568 | Phosphorylation | score2 | PhosphoSitePlus UniProt | 21406692 | ||
| S570 | Phosphorylation | score1 | PhosphoSitePlus | |||
| S575 | Phosphorylation | score1 | PhosphoSitePlus |
| Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
|---|---|---|---|---|---|---|
| T217 | Phosphorylation | score0 | HPRD | 20068231 | ||
| T236 | Phosphorylation | score0 | HPRD | 20068231 | ||
| S246 | Phosphorylation | score0 | HPRD | 20068231 | ||
| S257 | Phosphorylation | score0 | HPRD | 20068231 | ||
| S542 | Phosphorylation | score0 | HPRD | 20058876 | ||
| S548 | Phosphorylation | score0 | HPRD | 19651622, 20058876, 20068231 | ||
| S553 | Phosphorylation | score0 | HPRD | 17081983 | ||
| S554 | Phosphorylation | score0 | HPRD | 19651622, 17081983, 20068231 | ||
| S556 | Phosphorylation | score0 | HPRD | 19413330, 17081983, 20058876, ... | ||
| S560 | Phosphorylation | score0 | HPRD | 19651622, 17081983, 20068231 | ||
| S568 | Phosphorylation | score0 | HPRD | 20068231 |
PTM sites affected in variants
| Site | Variant | Source | PMID | Disease [Sample source] |
|---|---|---|---|---|
| K68 | I68 | Biomuta | DOID:5041 / esophageal cancer [ cosmic ] | |
| K68 | E68 | Biomuta | DOID:1612 / breast cancer [ cosmic ] | |
| K68 | T68 | Biomuta | DOID:2531 / hematologic cancer [ cosmic ] | |
| R122 | Q122 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] | |
| S246 | G246 | Biomuta | DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ] | |
| S321 | C321 | Biomuta | DOID:5041 / esophageal cancer [ cosmic ] | |
| K339 | N339 | Biomuta | DOID:10534 / stomach cancer [ cosmic ] | |
| K385 | R385 | Biomuta | DOID:10534 / stomach cancer [ cosmic ] | |
| S542 | P542 | Biomuta | DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ] | |
| S548 | F548 | Biomuta | [ cosmic ] | |
| S568 | N568 | Biomuta | DOID:10534 / stomach cancer [ cosmic, icgc ] |
DAG View