iPTMnet Report for P19525 (EIF2AK2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P19525 / E2AK2_HUMAN
Protein Name Interferon-induced, double-stranded RNA-activated protein kinase
Gene Name Name: EIF2AK2
Synonyms:PKR,PRKR;
Organism Homo sapiens (Human)

PRO ID PR:P19525
DAG View
PRO Name interferon-induced, double-stranded RNA-activated protein kinase (human)
Definition An interferon-induced, double-stranded RNA-activated protein kinase that is encoded in the genome of human.
Short Label hEIF2AK2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P19525 (EIF2AK2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
A2 Acetylation UniProt 22814378, 22223895
S6 Phosphorylation PhosphoSitePlus   RLIMS-P 33911136
K20 Ubiquitination PhosphoSitePlus
S33 Phosphorylation PhosphoSitePlus
K61 Methylation PhosphoSitePlus
K69 Methylation PhosphoSitePlus
K69 Ubiquitination PhosphoSitePlus
K77 Ubiquitination PhosphoSitePlus
K80 Ubiquitination PhosphoSitePlus
S83 Phosphorylation P19525 (EIF2AK2) phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 18669648, 11152499, 19690332, ...20068231
T88 Phosphorylation P19525 (EIF2AK2) phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 11152499
T89 Phosphorylation P19525 (EIF2AK2) phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 11152499
T90 Phosphorylation P19525 (EIF2AK2) phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 18669648, 11152499
S92 Phosphorylation PhosphoSitePlus
S93 Phosphorylation PhosphoSitePlus
S97 Phosphorylation PhosphoSitePlus
Y101 Phosphorylation P19525 (EIF2AK2) phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 17290288, 16373505
K140 Ubiquitination PhosphoSitePlus
Y142 Phosphorylation PhosphoSitePlus
K150 Ubiquitination PhosphoSitePlus
K159 Ubiquitination PhosphoSitePlus
Y162 Phosphorylation P19525 (EIF2AK2) phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 29070839, 16373505
S179 Phosphorylation PhosphoSitePlus
S181 Phosphorylation PhosphoSitePlus
S225 Phosphorylation RLIMS-P 32801355
S242 Phosphorylation P19525 (EIF2AK2) phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 8887659, 11152499, 9528799
K253 Ubiquitination PhosphoSitePlus
T255 Phosphorylation P19525 (EIF2AK2) phospho.ELM   PhosphoSitePlus   Signor   UniProt 9528799, 11152499, 8887659
Y257 Phosphorylation PhosphoSitePlus
T258 Phosphorylation P19525 (EIF2AK2) phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 9528799, 11152499, 8887659, ...11337501
K268 Ubiquitination PhosphoSitePlus
Y293 Phosphorylation P19525 (EIF2AK2) phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 17290288, 16373505
K299 Ubiquitination PhosphoSitePlus
K304 Ubiquitination PhosphoSitePlus
K380 Ubiquitination PhosphoSitePlus
K385 Ubiquitination PhosphoSitePlus
K388 Ubiquitination PhosphoSitePlus
K400 Ubiquitination PhosphoSitePlus
S407 Phosphorylation PhosphoSitePlus
K408 Ubiquitination PhosphoSitePlus
K416 Ubiquitination PhosphoSitePlus
K426 Ubiquitination PhosphoSitePlus
K429 Ubiquitination PhosphoSitePlus
T437 Phosphorylation PhosphoSitePlus
S438 Phosphorylation PhosphoSitePlus
K440 Ubiquitination PhosphoSitePlus
K444 Ubiquitination PhosphoSitePlus
T446 Phosphorylation P19525 (EIF2AK2) phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 21738672, 11337501, 33552025, ...29053745, 26490959, 28300830, 32221365, 21418572, 32539931, 22912779, 16179259, 16179258, 33911136, 27088597, 25146252, 15323561, 20457754, 15880455, 33248325, 32813746, 23259068, 33236446, 23557442, 9528799, 31086176, 30575730, 11432733
T451 Phosphorylation P51812 (RPS6KA3) , P28482 (MAPK1) , P19525 (EIF2AK2) , Q16539 (MAPK14) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 19259124, 15323561, 13678666, ...25360179, 20685959, 33552025, 9528799, 11337501, 29084250, 21192654, 23029376, 29402958, 19151623, 29036202, 32801355, 17404396, 28202752, 33911136, 28300830, 27088597
Y454 Phosphorylation PhosphoSitePlus
S456 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
K509 Ubiquitination PhosphoSitePlus
K512 Ubiquitination PhosphoSitePlus
K517 Ubiquitination PhosphoSitePlus
K521 Ubiquitination PhosphoSitePlus
K522 Ubiquitination PhosphoSitePlus
R534 Methylation PhosphoSitePlus
T535 Phosphorylation PhosphoSitePlus
S542 Phosphorylation PhosphoSitePlus   UniProt 23186163
Site PTM Type PTM Enzyme Score Source PMID
S83 Phosphorylation HPRD 18669648, 20068231
T89 Phosphorylation HPRD 20068231
T90 Phosphorylation HPRD 18669648
S93 Phosphorylation HPRD 20068231
Y101 Phosphorylation P23458 (JAK1) , P19525 (EIF2AK2) HPRD 17290288, 16373505
Y162 Phosphorylation P19525 (EIF2AK2) HPRD 16373505
S242 Phosphorylation P19525 (EIF2AK2) HPRD 8887659, 9528799
T255 Phosphorylation P19525 (EIF2AK2) HPRD 8887659, 9528799
T258 Phosphorylation P19525 (EIF2AK2) HPRD 8887659, 9528799, 20068231
Y293 Phosphorylation P19525 (EIF2AK2) , P23458 (JAK1) HPRD 17290288, 16373505
T446 Phosphorylation P19525 (EIF2AK2) HPRD 11337501
T451 Phosphorylation P19525 (EIF2AK2) HPRD 11337501
S456 Phosphorylation HPRD 18669648
S542 Phosphorylation HPRD 20068231


P19525 (EIF2AK2) as PTM Enzyme



Substrate Site Score Source PMID
P04637 (TP53) S392 HPRD   PhosphoSitePlus   Signor 19413330, 10747897, 10348343, ...10884347
P05198 (EIF2S1) S49 phospho.ELM   PhosphoSitePlus 16288713, 3352609
P05198 (EIF2S1) S52 HPRD   phospho.ELM   PhosphoSitePlus   Signor 16288713, 11432733, 17553788, ...7622470, 3352609, 18063576, 9819435, 10542257, 15060162, 16179259, 16179258, 17404396, 7641700, 1677563
P06493 (CDK1) Y4 PhosphoSitePlus   Signor 20395957
P10636-8 (MAPT) S262 PhosphoSitePlus 20067632
P10636-8 (MAPT) S356 PhosphoSitePlus 20067632
P19525 (EIF2AK2) S83 phospho.ELM   PhosphoSitePlus   Signor 11152499
P19525 (EIF2AK2) T88 phospho.ELM   PhosphoSitePlus   Signor   UniProt 11152499
P19525 (EIF2AK2) T89 phospho.ELM   PhosphoSitePlus   Signor   UniProt 11152499
P19525 (EIF2AK2) T90 phospho.ELM   PhosphoSitePlus   Signor   UniProt 11152499
P19525 (EIF2AK2) Y101 HPRD   PhosphoSitePlus   Signor   UniProt 16373505
P19525 (EIF2AK2) Y162 HPRD   PhosphoSitePlus   Signor   UniProt 16373505
P19525 (EIF2AK2) S242 HPRD   phospho.ELM   PhosphoSitePlus   Signor   UniProt 8887659, 11152499, 9528799
P19525 (EIF2AK2) T255 HPRD   phospho.ELM   PhosphoSitePlus   Signor   UniProt 9528799, 11152499, 8887659
P19525 (EIF2AK2) T258 HPRD   phospho.ELM   PhosphoSitePlus   Signor   UniProt 9528799, 11152499, 8887659, ...20068231, 11337501
P19525-1 (EIF2AK2) Y293 HPRD   PhosphoSitePlus   Signor   UniProt 16373505
P19525-1 (EIF2AK2) T446 HPRD   phospho.ELM   PhosphoSitePlus   UniProt 11432733, 9528799, 11337501, ...16179259
P19525-1 (EIF2AK2) T451 HPRD   phospho.ELM   PhosphoSitePlus   Signor   UniProt 9528799, 11337501
P25963 (NFKBIA) S32 HPRD 8601309, 10723127, 9721103, ...9214631
P42224 (STAT1) S727 RLIMS-P+ 23597922
Q15172 (PPP2R5A) S28 HPRD   PhosphoSitePlus   Signor 10866685, 18957415


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation O75569 (PRKRA) S287 P19525 (EIF2AK2) increased_association eFIP 23658827