iPTMnet Report for P19474 (TRIM21)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P19474 / RO52_HUMAN
Protein Name E3 ubiquitin-protein ligase TRIM21
Gene Name Name: TRIM21
Synonyms:RNF81,RO52,SSA1;
Organism Homo sapiens (Human)

PRO ID PR:P19474
DAG View
PRO Name E3 ubiquitin-protein ligase TRIM21 (human)
Definition An E3 ubiquitin-protein ligase TRIM21 that is encoded in the genome of human.
Short Label hTRIM21
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P19474 (TRIM21) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K61 Ubiquitination PhosphoSitePlus
S80 Phosphorylation RLIMS-P 29667579
K105 Ubiquitination PhosphoSitePlus
K138 Methylation PhosphoSitePlus
K138 Ubiquitination PhosphoSitePlus
K149 Ubiquitination PhosphoSitePlus
K186 Ubiquitination PhosphoSitePlus
K202 Ubiquitination PhosphoSitePlus
K214 Ubiquitination PhosphoSitePlus
S256 Phosphorylation PhosphoSitePlus
K260 Ubiquitination PhosphoSitePlus
S266 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 21406692, ...20068231
K279 Ubiquitination PhosphoSitePlus
C285 Methylation IEDB 31844290
R324 Methylation PhosphoSitePlus
Y343 Phosphorylation RLIMS-P 22479513
K351 Acetylation PhosphoSitePlus
K351 Ubiquitination PhosphoSitePlus
C359 Methylation IEDB 31844290
S362 Phosphorylation PhosphoSitePlus
K366 Ubiquitination PhosphoSitePlus
K385 Acetylation PhosphoSitePlus
K387 Acetylation PhosphoSitePlus
Y388 Phosphorylation RLIMS-P 22479513
Y393 Phosphorylation PhosphoSitePlus   RLIMS-P 22479513
S447 Phosphorylation PhosphoSitePlus
S469 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S266 Phosphorylation HPRD 17322306, 18669648, 20068231


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S80 I80 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
Y343 C343 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]