iPTMnet Report for P19447 (ERCC3)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P19447 / ERCC3_HUMAN
Protein Name General transcription and DNA repair factor IIH helicase subunit XPB
Gene Name Name: ERCC3
Synonyms:XPB,XPBC;
Organism Homo sapiens (Human)

PRO ID PR:P19447
DAG View
PRO Name general transcription and DNA repair factor IIH helicase subunit XPB (human)
Definition A general transcription and DNA repair factor IIH helicase subunit XPB that is encoded in the genome of human.
Short Label hERCC3
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P19447 (ERCC3) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
Y19 Phosphorylation PhosphoSitePlus
K44 Ubiquitination PhosphoSitePlus
K52 Ubiquitination PhosphoSitePlus
K59 Ubiquitination PhosphoSitePlus
Y139 Phosphorylation PhosphoSitePlus
K145 Ubiquitination PhosphoSitePlus
K157 Ubiquitination PhosphoSitePlus
K171 Ubiquitination PhosphoSitePlus
S202 Phosphorylation PhosphoSitePlus
T207 Phosphorylation PhosphoSitePlus
K217 Ubiquitination PhosphoSitePlus
K222 Ubiquitination PhosphoSitePlus
T232 Phosphorylation PhosphoSitePlus
T236 Phosphorylation PhosphoSitePlus
S242 Phosphorylation PhosphoSitePlus
K311 Sumoylation PhosphoSitePlus
K311 Ubiquitination PhosphoSitePlus
Y319 Phosphorylation PhosphoSitePlus
S323 Phosphorylation PhosphoSitePlus
S370 Phosphorylation HPRD   phospho.ELM 17081983
C390 Methylation IEDB 31844290
S404 Phosphorylation PhosphoSitePlus
T456 Phosphorylation IEDB 35494241
K526 Ubiquitination PhosphoSitePlus
C544 Methylation IEDB 31844290
K577 Ubiquitination PhosphoSitePlus
Y581 Phosphorylation PhosphoSitePlus
K601 Ubiquitination PhosphoSitePlus
S686 Phosphorylation PhosphoSitePlus   UniProt 23186163
K706 Ubiquitination PhosphoSitePlus
T720 Phosphorylation PhosphoSitePlus
S751 Phosphorylation P68400 (CSNK2A1) HPRD   phospho.ELM   PhosphoSitePlus   RLIMS-P 15549133, 23385459
Y758 Phosphorylation PhosphoSitePlus
K771 Ubiquitination PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K222 Q222 Biomuta DOID:9253 / gastrointestinal stromal tumor [ cosmic ]
S323 N323 Biomuta DOID:5158 / pleural cancer [ cosmic ]
S370 F370 Biomuta DOID:4159 / skin cancer [ cosmic ]
S370 T370 Biomuta DOID:10283 / prostate cancer [ cosmic ]
C390 S390 Biomuta DOID:1793 / pancreatic cancer [ cosmic ]