Protein Information

Cytoscape View


UniProt AC / UniProt ID P19388 / RPAB1_HUMAN
Protein Name DNA-directed RNA polymerases I, II, and III subunit RPABC1
Gene Name Name: POLR2E
Organism Homo sapiens (Human)

PRO ID PR:P19388
DAG View
PRO Name DNA-directed RNA polymerases I, II, and III subunit RPABC1 (human)
Definition A DNA-directed RNA polymerases I, II, and III subunit RPABC1 that is encoded in the genome of human.
Short Label hPOLR2E
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P19388 (POLR2E) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
M1 Acetylation UniProt 19413330, 22814378
R9 Methylation PhosphoSitePlus
K15 Ubiquitination PhosphoSitePlus
T29 Phosphorylation PhosphoSitePlus
T56 Phosphorylation HPRD   PhosphoSitePlus 18452278
T59 Phosphorylation HPRD   PhosphoSitePlus 18452278
K81 Ubiquitination PhosphoSitePlus
K85 Ubiquitination PhosphoSitePlus
K88 Ubiquitination PhosphoSitePlus
T111 Phosphorylation PhosphoSitePlus
K115 Ubiquitination PhosphoSitePlus
K186 Ubiquitination PhosphoSitePlus
K192 Ubiquitination PhosphoSitePlus


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation O94763 (URI1) T241 P19388 (POLR2E) inhibited_association eFIP 23667685


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K85 Q85 Biomuta DOID:1324 / lung cancer [ cosmic ]