iPTMnet Report for P19388 (POLR2E)
Protein Information
| UniProt AC / UniProt ID | P19388 / RPAB1_HUMAN |
| Protein Name | DNA-directed RNA polymerases I, II, and III subunit RPABC1 |
| Gene Name | Name: POLR2E |
| Organism | Homo sapiens (Human) |
| PRO ID | PR:P19388 |
| PRO Name | DNA-directed RNA polymerases I, II, and III subunit RPABC1 (human) |
| Definition | A DNA-directed RNA polymerases I, II, and III subunit RPABC1 that is encoded in the genome of human. |
| Short Label | hPOLR2E |
| Category | organism-gene |
DAG ViewP19388 (POLR2E) as Substrate
 |
Site | PTM Type | PTM Enzyme | Score | Source | PMID |
|---|---|---|---|---|---|---|
| M1 | Acetylation | score1 | UniProt | 19413330, 22814378 | ||
| R9 | Methylation | score1 | PhosphoSitePlus | |||
| K15 | Ubiquitination | score1 | PhosphoSitePlus | |||
| T29 | Phosphorylation | score1 | PhosphoSitePlus | |||
| T56 | Phosphorylation | score2 | HPRD PhosphoSitePlus | 18452278 | ||
| T59 | Phosphorylation | score2 | HPRD PhosphoSitePlus | 18452278 | ||
| K81 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K85 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K88 | Ubiquitination | score1 | PhosphoSitePlus | |||
| T111 | Phosphorylation | score1 | PhosphoSitePlus | |||
| K115 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K186 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K192 | Ubiquitination | score1 | PhosphoSitePlus |
PTM-dependent PPI
|
PTM type | Substrate | Site | Interactant | Association type | Source | PMID |
|---|---|---|---|---|---|---|---|
| Phosphorylation | O94763 (URI1) | T241 | P19388 (POLR2E) | inhibited_association | eFIP | 23667685 |
PTM sites affected in variants
| Site | Variant | Source | PMID | Disease [Sample source] |
|---|---|---|---|---|
| R9 | G9 | Biomuta | DOID:1793 / pancreatic cancer [ cosmic ] | |
| K85 | Q85 | Biomuta | DOID:1324 / lung cancer [ cosmic ] |
