iPTMnet Report for P19387 (POLR2C)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P19387 / RPB3_HUMAN
Protein Name DNA-directed RNA polymerase II subunit RPB3
Gene Name Name: POLR2C
ORFNames:A-152E5.7;
Organism Homo sapiens (Human)

PRO ID PR:P19387
DAG View
PRO Name DNA-directed RNA polymerase II subunit RPB3 (human)
Definition A DNA-directed RNA polymerase II subunit RPB3 that is encoded in the genome of human.
Short Label hPOLR2C
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P19387 (POLR2C) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
T12 Phosphorylation PhosphoSitePlus
K20 Ubiquitination PhosphoSitePlus
K81 Ubiquitination PhosphoSitePlus
S124 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18669648, 20068231
Y142 Phosphorylation PhosphoSitePlus
K152 Ubiquitination PhosphoSitePlus
K175 Sumoylation PhosphoSitePlus
K175 Ubiquitination PhosphoSitePlus
K199 Sumoylation PhosphoSitePlus
K199 Ubiquitination PhosphoSitePlus
K205 Sumoylation PhosphoSitePlus
K205 Ubiquitination PhosphoSitePlus
S206 Phosphorylation PhosphoSitePlus
Y208 Phosphorylation PhosphoSitePlus
S209 Phosphorylation PhosphoSitePlus
S216 Phosphorylation PhosphoSitePlus
Y220 Phosphorylation PhosphoSitePlus
K225 Ubiquitination PhosphoSitePlus
S235 Phosphorylation PhosphoSitePlus
K253 Ubiquitination PhosphoSitePlus
K255 Ubiquitination PhosphoSitePlus
S257 Phosphorylation PhosphoSitePlus   UniProt 24275569


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K81 N81 Biomuta DOID:3571 / liver cancer [ cosmic ]
S124 I124 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
Y208 H208 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
S209 L209 Biomuta DOID:363 / uterine cancer [ cosmic ] DOID:4159 / skin cancer [ cosmic ]
S216 L216 Biomuta DOID:363 / uterine cancer [ icgc ]
K255 T255 Biomuta DOID:1324 / lung cancer [ cosmic ]