iPTMnet Report for P19367 (HK1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P19367 / HXK1_HUMAN
Protein Name Hexokinase-1
Gene Name Name: HK1
Organism Homo sapiens (Human)

PRO ID PR:P19367
DAG View
PRO Name hexokinase-1 (human)
Definition A hexokinase-1 that is encoded in the genome of human.
Short Label hHK1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P19367 (HK1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
M1 Acetylation UniProt 19413330, 25944712
Y25 Phosphorylation PhosphoSitePlus
Y27 Phosphorylation PhosphoSitePlus
K62 Ubiquitination PhosphoSitePlus
K77 Acetylation PhosphoSitePlus
S124 Phosphorylation PhosphoSitePlus
C133 Methylation IEDB 31844290
K147 Ubiquitination PhosphoSitePlus
S155 Phosphorylation PhosphoSitePlus
K173 Ubiquitination PhosphoSitePlus
K176 Methylation PhosphoSitePlus
K176 Ubiquitination PhosphoSitePlus
S178 Phosphorylation PhosphoSitePlus
K187 Ubiquitination PhosphoSitePlus
K191 Ubiquitination PhosphoSitePlus
S269 Phosphorylation PhosphoSitePlus
K290 Ubiquitination PhosphoSitePlus
S298 Phosphorylation PhosphoSitePlus
Y301 Phosphorylation PhosphoSitePlus
K315 Ubiquitination PhosphoSitePlus
K333 Acetylation PhosphoSitePlus
K333 Ubiquitination PhosphoSitePlus
S337 Phosphorylation PhosphoSitePlus
S340 Phosphorylation PhosphoSitePlus
K344 Ubiquitination PhosphoSitePlus
K346 Ubiquitination PhosphoSitePlus
S364 Phosphorylation PhosphoSitePlus
T403 Phosphorylation PhosphoSitePlus
Y417 Phosphorylation PhosphoSitePlus
K418 Ubiquitination PhosphoSitePlus
T419 Phosphorylation PhosphoSitePlus
Y461 Phosphorylation PhosphoSitePlus
K489 Acetylation PhosphoSitePlus
K501 Ubiquitination PhosphoSitePlus
T503 Phosphorylation PhosphoSitePlus
K510 Ubiquitination PhosphoSitePlus
K544 Acetylation PhosphoSitePlus
K624 Ubiquitination PhosphoSitePlus
Y686 Phosphorylation RLIMS-P 28054552
R727 Methylation PhosphoSitePlus
Y732 Phosphorylation PhosphoSitePlus   RLIMS-P+ 28054552
Y732 Phosphorylation P12931 (SRC) RLIMS-P+ 28054552
S733 Phosphorylation PhosphoSitePlus
K738 Ubiquitination PhosphoSitePlus
Y749 Phosphorylation PhosphoSitePlus
K763 Acetylation PhosphoSitePlus
K763 Ubiquitination PhosphoSitePlus
K777 Ubiquitination PhosphoSitePlus
S792 Phosphorylation PhosphoSitePlus
C813 S-Nitrosylation dbSNO 19483679
T821 O-Glycosylation GlyGen 30379171, 34019948, 34725712, ...32119511
T821 Phosphorylation PhosphoSitePlus
C823 S-Nitrosylation dbSNO 26338901
S827 Phosphorylation PhosphoSitePlus
R849 Methylation PhosphoSitePlus
K880 Ubiquitination PhosphoSitePlus
K885 Ubiquitination PhosphoSitePlus
S893 Phosphorylation PhosphoSitePlus
T913 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S32 Phosphorylation HPRD 20068231
S298 Phosphorylation HPRD 20068231
Y301 Phosphorylation HPRD 19413330, 20068231
Site PTM Type PTM Enzyme Score Source PMID
S31 Phosphorylation HPRD 20068231
S297 Phosphorylation HPRD 20068231
Y300 Phosphorylation HPRD 19413330, 20068231
Site PTM Type PTM Enzyme Score Source PMID
S36 Phosphorylation HPRD 20068231
S302 Phosphorylation HPRD 20068231
Y305 Phosphorylation HPRD 19413330, 20068231
Site PTM Type PTM Enzyme Score Source PMID
S20 Phosphorylation HPRD 20068231
S286 Phosphorylation HPRD 20068231
Y289 Phosphorylation HPRD 19413330, 20068231


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S20 F20 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
Y27 H27 Biomuta DOID:9256 / colorectal cancer [ icgc ]
S31 F31 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S32 F32 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S36 F36 Biomuta DOID:4159 / skin cancer [ cosmic ]
S155 F155 Biomuta DOID:4159 / skin cancer [ cosmic ]
S178 C178 Biomuta DOID:3571 / liver cancer [ cosmic ]
S178 G178 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
K187 N187 Biomuta DOID:2394 / ovarian cancer [ cosmic ]
K346 Q346 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
T419 M419 Biomuta DOID:10534 / stomach cancer [ cosmic ]
K501 N501 Biomuta DOID:5041 / esophageal cancer [ cosmic ]
T503 M503 Biomuta DOID:4606 / bile duct cancer [ cosmic ]
K624 N624 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
K777 N777 Biomuta DOID:1324 / lung cancer [ cosmic ]