iPTMnet Report for P19338 (NCL)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P19338 / NUCL_HUMAN
Protein Name Nucleolin
Gene Name Name: NCL
Organism Homo sapiens (Human)

PRO ID PR:P19338
DAG View
PRO Name nucleolin (human)
Definition A nucleolin that is encoded in the genome of human.
Short Label hNCL
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P19338 (NCL) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K3 Methylation PhosphoSitePlus
K9 Acetylation PhosphoSitePlus   UniProt 19608861
K15 Acetylation PhosphoSitePlus
K16 Acetylation PhosphoSitePlus
S28 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 17081983, 15302935, 19415658, ...18669648, 18452278, 19690332, 20068231
S34 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 17081983, 18452278, 18669648, ...19415658, 19690332, 20068231
S41 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 17081983, 18452278, 18669648, ...24275569, 19415658, 20068231
S42 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 17081983, 18452278, 18669648, ...24275569, 19415658, 20068231
S60 Phosphorylation PhosphoSitePlus
K62 Acetylation PhosphoSitePlus
K63 Acetylation PhosphoSitePlus
K63 Ubiquitination PhosphoSitePlus
S67 Phosphorylation HPRD   IEDB   phospho.ELM   PhosphoSitePlus   UniProt 27869121, 21406692, 23186163, ...18212344, 19691289, 18452278, 24275569, 19413330, 18767875, 18847512, 19007248, 19651622, 32387766, 16083285, 17287340, 17081983, 15302935, 19664995, 17322306, 18669648, 20166139, 19415658, 20068231, 17924679
S67 Phosphorylation P24941 (CDK2) PhosphoSitePlus 18847512
T69 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 17322306, 21406692, 17081983, ...18767875, 19691289, 19664995, 19651622, 18669648, 20166139, 19007248, 18452278, 17924679, 19415658, 20068231, 20068230
K70 Acetylation PhosphoSitePlus
K70 Ubiquitination PhosphoSitePlus
K71 Acetylation PhosphoSitePlus
K71 Methylation PhosphoSitePlus
K71 Ubiquitination PhosphoSitePlus
T76 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 16964243, 32851058, 23186163, ...18212344, 18847512, 19007248, 17322306, 18669648, 20068231, 17924679
T76 Phosphorylation P24941 (CDK2) PhosphoSitePlus 18847512
K79 Acetylation PhosphoSitePlus
K79 Ubiquitination PhosphoSitePlus
K80 Acetylation PhosphoSitePlus
K80 Methylation PhosphoSitePlus
T84 Phosphorylation HPRD   PhosphoSitePlus   RLIMS-P   UniProt 28332494, 32851058, 19651622, ...20068231
K87 Acetylation PhosphoSitePlus
K88 Acetylation PhosphoSitePlus
T92 Phosphorylation HPRD   PhosphoSitePlus   UniProt 20068231
K95 Acetylation PhosphoSitePlus
K96 Methylation PhosphoSitePlus
T97 Phosphorylation HPRD   PhosphoSitePlus 20068231
T99 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 16083285, 20068231, 20068230
K102 Acetylation PhosphoSitePlus   UniProt 19608861
K102 Ubiquitination PhosphoSitePlus
T105 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 16083285, 20068231
T106 Phosphorylation HPRD   PhosphoSitePlus   UniProt 19007248, 20068231
K109 Acetylation PhosphoSitePlus
K110 Acetylation PhosphoSitePlus
K110 Ubiquitination PhosphoSitePlus
T113 Phosphorylation HPRD   PhosphoSitePlus   UniProt 19007248, 20068231
K116 Acetylation PhosphoSitePlus   UniProt 19608861
K116 Methylation PhosphoSitePlus
K116 Ubiquitination PhosphoSitePlus
T121 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 19413330, 19664995, 23186163, ...17081983, 18767875, 18847512, 18234856, 19691289, 19007248, 19651622, 17322306, 18669648, 17924679, 18212344, 20068231, 16964243
T121 Phosphorylation P06493 (CDK1) PhosphoSitePlus 18234856
T121 Phosphorylation P24941 (CDK2) PhosphoSitePlus 18847512
K124 Acetylation PhosphoSitePlus   UniProt 19608861
K124 Ubiquitination PhosphoSitePlus
K125 Acetylation PhosphoSitePlus
K132 Acetylation PhosphoSitePlus
K132 Methylation PhosphoSitePlus
K135 Acetylation PhosphoSitePlus
S145 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 19413330, 18491316, 23186163, ...17081983, 20230923, 15302935, 18452278, 19651622, 18669648, 17487921, 15345747, 19415658, 20068231, 18212344
S153 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 19413330, 18491316, 23186163, ...18212344, 20230923, 15302935, 18452278, 19651622, 18669648, 17487921, 19415658, 20068231, 17081983
S184 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 17287340, 18452278, 18669648, ...24275569, 23186163, 17487921
S206 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18669648, 17487921, 23186163, ...18452278
T213 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18669648
T214 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18669648, 17287340, 18452278
K223 Acetylation PhosphoSitePlus
K223 Sumoylation PhosphoSitePlus
K223 Ubiquitination PhosphoSitePlus
K294 Acetylation PhosphoSitePlus
K294 Sumoylation PhosphoSitePlus
K297 Acetylation PhosphoSitePlus
K297 Sumoylation PhosphoSitePlus
T301 O-Glycosylation GlyGen 30444036, 34725712, 35138101, ...30379171, 32522876, 26853435, 33214551, 25367160, 29351928, 34019948, 35083852, 21740066, 20305658, 32119511, 22121020, 33465208
T301 Phosphorylation HPRD   PhosphoSitePlus   UniProt 19690332, 18452278
T304 Phosphorylation HPRD   PhosphoSitePlus 18452278
T305 Phosphorylation HPRD   PhosphoSitePlus 18452278
K318 Acetylation PhosphoSitePlus   UniProt 19608861
K318 Ubiquitination PhosphoSitePlus
K324 Sumoylation PhosphoSitePlus
K324 Ubiquitination PhosphoSitePlus
T325 Phosphorylation PhosphoSitePlus
S328 Phosphorylation PhosphoSitePlus
K333 Acetylation PhosphoSitePlus
K333 Methylation PhosphoSitePlus
K333 Ubiquitination PhosphoSitePlus
R342 Methylation PhosphoSitePlus
K348 Acetylation PhosphoSitePlus
K348 Ubiquitination PhosphoSitePlus
Y351 Phosphorylation PhosphoSitePlus
S356 Phosphorylation PhosphoSitePlus   UniProt 23186163
K362 Ubiquitination PhosphoSitePlus
T367 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 20068231
K370 Acetylation PhosphoSitePlus
K370 Ubiquitination PhosphoSitePlus
K377 Acetylation PhosphoSitePlus   UniProt 19608861
K377 Sumoylation PhosphoSitePlus
K377 Ubiquitination PhosphoSitePlus
K382 Ubiquitination PhosphoSitePlus
K387 Acetylation PhosphoSitePlus
K388 Acetylation PhosphoSitePlus
K398 Acetylation PhosphoSitePlus   UniProt 19608861
K398 Ubiquitination PhosphoSitePlus
Y402 Phosphorylation PhosphoSitePlus
K403 Acetylation PhosphoSitePlus   UniProt 19608861
K403 Sumoylation PhosphoSitePlus
K403 Ubiquitination PhosphoSitePlus
T405 Phosphorylation HPRD   PhosphoSitePlus   UniProt 18077418, 23186163
K410 Ubiquitination PhosphoSitePlus
R420 Methylation PhosphoSitePlus
S423 Phosphorylation PhosphoSitePlus
S428 Phosphorylation PhosphoSitePlus
K429 Ubiquitination PhosphoSitePlus
Y433 Phosphorylation PhosphoSitePlus
K437 Acetylation PhosphoSitePlus
K437 Sumoylation PhosphoSitePlus
T438 O-Glycosylation GlyGen 30444036, 34725712, 35138101, ...30379171, 32522876, 26853435, 33214551, 25367160, 29351928, 34019948, 35083852, 21740066, 20305658, 32119511, 22121020, 33465208
K444 Acetylation PhosphoSitePlus
K444 Ubiquitination PhosphoSitePlus
K449 Acetylation PhosphoSitePlus
K449 Ubiquitination PhosphoSitePlus
S458 Phosphorylation HPRD   PhosphoSitePlus   UniProt 23186163, 20068231
S460 Phosphorylation PhosphoSitePlus   UniProt 23186163
Y462 Phosphorylation PhosphoSitePlus
Y463 Phosphorylation PhosphoSitePlus
T464 Phosphorylation PhosphoSitePlus
K467 Acetylation PhosphoSitePlus
K467 Ubiquitination PhosphoSitePlus
Y473 Phosphorylation PhosphoSitePlus
R474 Methylation PhosphoSitePlus
K477 Acetylation PhosphoSitePlus
K477 Ubiquitination PhosphoSitePlus
T480 Phosphorylation PhosphoSitePlus
S482 Phosphorylation PhosphoSitePlus
K486 Sumoylation PhosphoSitePlus
K486 Ubiquitination PhosphoSitePlus
T487 Phosphorylation PhosphoSitePlus
S494 Phosphorylation PhosphoSitePlus
S496 Phosphorylation HPRD   PhosphoSitePlus 20068231, 18452278
T498 Phosphorylation HPRD   PhosphoSitePlus 20068231
K508 Ubiquitination PhosphoSitePlus
K513 Acetylation PhosphoSitePlus   UniProt 19608861
K513 Ubiquitination PhosphoSitePlus
K521 Ubiquitination PhosphoSitePlus
K523 Ubiquitination PhosphoSitePlus
Y525 Phosphorylation PhosphoSitePlus
S532 Phosphorylation PhosphoSitePlus
K537 Ubiquitination PhosphoSitePlus
S542 Phosphorylation PhosphoSitePlus
C543 S-Nitrosylation dbSNO 19483679
K545 Acetylation PhosphoSitePlus
K545 Ubiquitination PhosphoSitePlus
R561 Methylation PhosphoSitePlus
S563 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 17322306, 17081983, 16083285, ...17287340, 18212344, 18767875, 19007248, 19651622, 18669648, 21406692, 23186163, 19415658, 20068231, 17924679
K572 Acetylation PhosphoSitePlus   UniProt 19608861
K572 Ubiquitination PhosphoSitePlus
K577 Acetylation PhosphoSitePlus   UniProt 19608861
K577 Sumoylation PhosphoSitePlus
K577 Ubiquitination PhosphoSitePlus
S580 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 16964243, ...19007248, 19691289, 24275569
T583 Phosphorylation PhosphoSitePlus
T587 O-Glycosylation GlyGen 30444036, 34725712, 35138101, ...30379171, 32522876, 26853435, 33214551, 25367160, 29351928, 34019948, 35083852, 21740066, 20305658, 32119511, 22121020, 33465208
T587 Phosphorylation PhosphoSitePlus
K589 Sumoylation PhosphoSitePlus
K589 Ubiquitination PhosphoSitePlus
S591 Phosphorylation PhosphoSitePlus   UniProt 24275569
S595 Phosphorylation HPRD   PhosphoSitePlus 20068231
R597 Methylation PhosphoSitePlus
T602 Phosphorylation PhosphoSitePlus
R604 Methylation PhosphoSitePlus
T606 Phosphorylation PhosphoSitePlus
S608 Phosphorylation PhosphoSitePlus
S609 Phosphorylation PhosphoSitePlus
K610 Acetylation PhosphoSitePlus
K610 Ubiquitination PhosphoSitePlus
S619 O-Glycosylation GlyGen 30444036, 34725712, 35138101, ...30379171, 32522876, 26853435, 33214551, 25367160, 29351928, 34019948, 35083852, 21740066, 20305658, 32119511, 22121020, 33465208
S619 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 19413330, 17322306, 21406692, ...23186163, 16964243, 18767875, 19664995, 18452278, 19651622, 18669648, 24275569, 20068231
K624 Acetylation PhosphoSitePlus
K624 Sumoylation PhosphoSitePlus
K624 Ubiquitination PhosphoSitePlus
K639 Ubiquitination PhosphoSitePlus
T641 O-Glycosylation GlyGen 30444036, 34725712, 35138101, ...30379171, 32522876, 26853435, 33214551, 25367160, 29351928, 34019948, 35083852, 21740066, 20305658, 32119511, 22121020, 33465208
T641 Phosphorylation PhosphoSitePlus   RLIMS-P 21998300
T641 Phosphorylation P06493 (CDK1) PhosphoSitePlus 21998300
K646 Acetylation PhosphoSitePlus   UniProt 19608861
K646 Methylation PhosphoSitePlus
K646 Ubiquitination PhosphoSitePlus
R656 Methylation PhosphoSitePlus
R660 Methylation PhosphoSitePlus
R666 Methylation PhosphoSitePlus
R670 Methylation PhosphoSitePlus
R673 Methylation PhosphoSitePlus
R679 Methylation PhosphoSitePlus
R681 Methylation PhosphoSitePlus
R687 Methylation PhosphoSitePlus
R691 Methylation PhosphoSitePlus
R694 Methylation PhosphoSitePlus
T707 Phosphorylation PhosphoSitePlus   RLIMS-P 21998300
T707 Phosphorylation P06493 (CDK1) PhosphoSitePlus 21998300


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K71 N71 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
T213 S213 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
T367 A367 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]
K370 Q370 Biomuta DOID:4159 / skin cancer [ cosmic ]
K403 R403 Biomuta DOID:363 / uterine cancer [ icgc ]
R420 I420 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S428 I428 Biomuta DOID:4606 / bile duct cancer [ cosmic ]
Y463 C463 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
R474 I474 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
T480 A480 Biomuta DOID:1319 / brain cancer [ cosmic ]
T498 I498 Biomuta DOID:4159 / skin cancer [ cosmic ]
Y525 * Biomuta DOID:4159 / skin cancer [ cosmic ]
C543 Y543 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K577 N577 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K577 * Biomuta DOID:9256 / colorectal cancer [ cosmic ]
T587 A587 Biomuta DOID:1319 / brain cancer [ cosmic, icgc ]
R597 W597 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
R604 Q604 Biomuta DOID:4362 / cervical cancer [ cosmic, icgc ] DOID:9256 / colorectal cancer [ cosmic, icgc ]
R604 W604 Biomuta DOID:4159 / skin cancer [ cosmic ]
R660 G660 Biomuta DOID:4159 / skin cancer [ cosmic ]
R673 Q673 Biomuta DOID:5041 / esophageal cancer [ cosmic, icgc ]
R679 K679 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
R681 Q681 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
R687 Q687 Biomuta DOID:3571 / liver cancer [ cosmic ]
R691 G691 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
R691 * Biomuta [ cosmic ]
T707 P707 Biomuta DOID:9256 / colorectal cancer [ cosmic ]