Protein Information

Cytoscape View


UniProt AC / UniProt ID P19256 / LFA3_HUMAN
Protein Name Lymphocyte function-associated antigen 3 precursor
Gene Name Name: CD58
Synonyms:LFA3;
Organism Homo sapiens (Human)

PRO ID PR:P19256
DAG View
PRO Name lymphocyte function-associated antigen 3 (human)
Definition A lymphocyte function-associated antigen 3 that is encoded in the genome of human.
Short Label hCD58
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P19256 (CD58) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K62 Ubiquitination PhosphoSitePlus
K78 Ubiquitination PhosphoSitePlus
N169 N-Glycosylation GlyGen 23090970, 29741879, 24190977
N195 N-Glycosylation GlyGen 24190977
S209 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
T247 Phosphorylation PhosphoSitePlus


Proteoform PPIs

Protein 1 Relation Protein 2 Source PMID
PR:000036596 (hCD2/iso:1/SigPep-/NGlyco:1) Interaction PR:P19256 (hCD58) PRO 7544493, 7688025
PR:P19256 (hCD58) Interaction PR:000036596 (hCD2/iso:1/SigPep-/NGlyco:1) PRO 7544493, 7688025


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K62 E62 Biomuta DOID:1793 / pancreatic cancer [ tcga ] DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
K78 * Biomuta DOID:3571 / liver cancer [ tcga ]
N169 K169 Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
N195 K195 Biomuta DOID:1909 / melanoma [ cosmic ]