iPTMnet Report for P19256 (CD58)
Protein Information
| UniProt AC / UniProt ID | P19256 / LFA3_HUMAN |
| Protein Name | Lymphocyte function-associated antigen 3 precursor |
| Gene Name | Name: CD58 Synonyms:LFA3; |
| Organism | Homo sapiens (Human) |
| PRO ID | PR:P19256 |
| PRO Name | lymphocyte function-associated antigen 3 (human) |
| Definition | A lymphocyte function-associated antigen 3 that is encoded in the genome of human. |
| Short Label | hCD58 |
| Category | organism-gene |
DAG ViewP19256 (CD58) as Substrate
 |
Site | PTM Type | PTM Enzyme | Score | Source | PMID |
|---|---|---|---|---|---|---|
| K62 | Ubiquitination | score1 | PhosphoSitePlus | |||
| K78 | Ubiquitination | score1 | PhosphoSitePlus | |||
| N169 | N-Glycosylation | score1 | GlyGen | 23090970, 29741879, 24190977 | ||
| N195 | N-Glycosylation | score1 | GlyGen | 24190977 | ||
| S209 | Phosphorylation | score1 | PhosphoSitePlus |
|
Site | PTM Type | PTM Enzyme | Score | Source | PMID |
|---|---|---|---|---|---|---|
| T247 | Phosphorylation | score1 | PhosphoSitePlus |
Proteoform PPIs
|
Protein 1 | Relation | Protein 2 | Source | PMID |
|---|---|---|---|---|---|
| PR:000036596 (hCD2/iso:1/SigPep-/NGlyco:1) | Interaction | PR:P19256 (hCD58) | PRO | 7544493, 7688025 | |
| PR:P19256 (hCD58) | Interaction | PR:000036596 (hCD2/iso:1/SigPep-/NGlyco:1) | PRO | 7544493, 7688025 |
PTM sites affected in variants
| Site | Variant | Source | PMID | Disease [Sample source] |
|---|---|---|---|---|
| K62 | * | Biomuta | DOID:2531 / hematologic cancer [ cosmic ] | |
| K62 | E62 | Biomuta | DOID:1793 / pancreatic cancer [ cosmic, icgc ] DOID:3571 / liver cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic ] | |
| K78 | * | Biomuta | DOID:3571 / liver cancer [ cosmic ] DOID:2531 / hematologic cancer [ cosmic ] | |
| N169 | K169 | Biomuta | DOID:3571 / liver cancer [ cosmic ] | |
| N195 | K195 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] |
