Protein Information

Cytoscape View


UniProt AC / UniProt ID P19174 / PLCG1_HUMAN
Protein Name 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1
Gene Name Name: PLCG1
Synonyms:PLC1;
Organism Homo sapiens (Human)

PRO ID PR:P19174
DAG View
PRO Name 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 (human)
Definition A 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 that is encoded in the genome of human.
Short Label hPLCG1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P19174 (PLCG1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
Phosphorylation PRO
A2 Acetylation UniProt 19413330
S6 Phosphorylation PhosphoSitePlus
K54 Ubiquitination PhosphoSitePlus
S63 O-Glycosylation GlyGen 29351928
K68 Ubiquitination PhosphoSitePlus
Y93 Phosphorylation PhosphoSitePlus
K159 Ubiquitination PhosphoSitePlus
K175 Ubiquitination PhosphoSitePlus
K178 Ubiquitination PhosphoSitePlus
Y186 Phosphorylation PhosphoSitePlus
Y210 Phosphorylation PhosphoSitePlus
S219 Phosphorylation PhosphoSitePlus
K226 Ubiquitination PhosphoSitePlus
S236 Phosphorylation PhosphoSitePlus
T237 Phosphorylation PhosphoSitePlus
Y379 Phosphorylation PhosphoSitePlus
K389 Ubiquitination PhosphoSitePlus
S412 Phosphorylation PhosphoSitePlus
Y428 Phosphorylation PhosphoSitePlus
K431 Ubiquitination PhosphoSitePlus
K440 Ubiquitination PhosphoSitePlus
S451 Phosphorylation PhosphoSitePlus
K456 Ubiquitination PhosphoSitePlus
K465 Ubiquitination PhosphoSitePlus
S470 Phosphorylation PhosphoSitePlus
Y472 Phosphorylation P00533 (EGFR) neXtProt   phospho.ELM   PRO   PhosphoSitePlus   Signor 7991458, 1689310, 12601080
T477 Phosphorylation PhosphoSitePlus
Y481 Phosphorylation PhosphoSitePlus   RLIMS-P 23028325
Y496 Phosphorylation PhosphoSitePlus
Y506 Phosphorylation PhosphoSitePlus
Y509 Phosphorylation PhosphoSitePlus
Y518 Phosphorylation PhosphoSitePlus
S525 Phosphorylation PhosphoSitePlus
S539 Phosphorylation PhosphoSitePlus
T542 Phosphorylation PhosphoSitePlus
K549 Ubiquitination PhosphoSitePlus
K554 Ubiquitination PhosphoSitePlus
S582 Phosphorylation PhosphoSitePlus
K666 Ubiquitination PhosphoSitePlus
Y669 Phosphorylation PhosphoSitePlus
Y702 Phosphorylation PhosphoSitePlus
K763 Ubiquitination PhosphoSitePlus
T766 Phosphorylation PhosphoSitePlus
Y771 Phosphorylation P43405 (SYK) , P00519 (ABL1) , P00533 (EGFR) , P07948 (LYN) neXtProt   phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P+   RLIMS-P   Signor   UniProt 12652307, 12601080, 20494825, ...15144186, 1708307, 8657103, 23059825, 29946469, 15592455, 1689310, 19690332, 16038803
Y775 Phosphorylation Q08881 (ITK) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 17420479, 17116690, 31889510, ...29946469, 15592455, 19690332
Y783 Phosphorylation Q08881 (ITK) , P43403 (ZAP70) , P43405 (SYK) , P07949 (RET) , P00533 (EGFR) , P54764 (EPHA4) neXtProt   phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P   Signor   UniProt 22745786, 17148460, 28798148, ...16467851, 23613900, 15623534, 17494698, 23629676, 23028325, 1689310, 31376383, 29066806, 30873169, 14568990, 25252913, 25140833, 25870599, 19690332, 16153436, 21760611, 12601080, 17420479, 24066087, 15161916, 29972810, 1708307, 16126727, 31889510, 15764700, 16038803, 27995987, 26295810, 11094067, 25916191, 22649724, 25734483, 23063561, 9176240, 15215251, 29743977, 9716455, 19179337, 25717186, 17220479, 8657103, 22665519, 11564877, 27764189, 16525023, 16081816, 28978037, 17116690, 24205378
T791 Phosphorylation PhosphoSitePlus
K793 Ubiquitination PhosphoSitePlus
K803 Ubiquitination PhosphoSitePlus
S815 Phosphorylation PhosphoSitePlus
K823 Ubiquitination PhosphoSitePlus
Y833 Phosphorylation PhosphoSitePlus
Y845 Phosphorylation RLIMS-P 17561374
K890 Ubiquitination PhosphoSitePlus
K941 Ubiquitination PhosphoSitePlus
S954 Phosphorylation PhosphoSitePlus
Y959 Phosphorylation PhosphoSitePlus
Y977 Phosphorylation phospho.ELM   PhosphoSitePlus 18083107
S981 Phosphorylation PhosphoSitePlus
S982 Phosphorylation PhosphoSitePlus
Y991 Phosphorylation PhosphoSitePlus
Y1003 Phosphorylation P00519 (ABL1) PhosphoSitePlus 12652307
C1060 S-Nitrosylation dbSNO 26338901
K1079 Ubiquitination PhosphoSitePlus
K1193 Ubiquitination PhosphoSitePlus
S1221 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 19690332, ...20068231
S1224 Phosphorylation PhosphoSitePlus
T1226 Phosphorylation PhosphoSitePlus
S1227 Phosphorylation PhosphoSitePlus   UniProt 23186163
R1231 Methylation PhosphoSitePlus
S1233 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 23186163, 18220336
S1236 Phosphorylation PhosphoSitePlus
R1243 Methylation PhosphoSitePlus
S1248 Phosphorylation P17252 (PRKCA) , P31749 (AKT1) , P17612 (PRKACA) , Q15139 (PRKD1) phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 16525023, 1370476, 28978037, ...28882164
S1251 Phosphorylation PhosphoSitePlus
Y1253 Phosphorylation P43403 (ZAP70) , P00533 (EGFR) neXtProt   phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P   Signor   UniProt 12601080, 17081983, 15161916, ...15144186, 1708307, 22847294, 1689310, 20068231
S1263 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 23186163, 18220336
S1273 Phosphorylation PhosphoSitePlus
R1283 Methylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S6 Phosphorylation HPRD 19413330
Y472 Phosphorylation P00533 (EGFR) HPRD 19901323, 1689310, 12601080
Y481 Phosphorylation HPRD 19901323
S525 Phosphorylation HPRD 19413330
Y771 Phosphorylation P43405 (SYK) , P07948 (LYN) , P08631 (HCK) , P00533 (EGFR) HPRD 17016520, 17389395, 7682059, ...15144186, 8657103, 1689310, 20068231, 16497976
Y775 Phosphorylation HPRD 15951569, 20068231, 16497976
Y783 Phosphorylation P07949 (RET) , P12931 (SRC) , P00533 (EGFR) , P08631 (HCK) , P07948 (LYN) , P43405 (SYK) HPRD 17016520, 17389395, 7682059, ...8657103, 20068231, 1689310, 8885868, 16497976
T791 Phosphorylation HPRD 20068231
Y977 Phosphorylation HPRD 18083107, 19901323
S1221 Phosphorylation HPRD 18669648, 19664994, 20068231
S1233 Phosphorylation HPRD 20068231
S1248 Phosphorylation Q15139 (PRKD1) HPRD 19651622, 20068231, 8885868
Y1253 Phosphorylation P08631 (HCK) HPRD 17016520, 17389395, 7682059, ...15144186, 20068231, 18707149, 8885868
S1263 Phosphorylation HPRD 18077418
Site PTM Type PTM Enzyme Score Source PMID
S6 Phosphorylation HPRD 19413330
Y472 Phosphorylation P00533 (EGFR) HPRD 19901323, 1689310, 12601080
Y481 Phosphorylation HPRD 19901323
S525 Phosphorylation HPRD 19413330
Y771 Phosphorylation P08631 (HCK) , P00533 (EGFR) , P43405 (SYK) , P07948 (LYN) HPRD 17016520, 17389395, 7682059, ...15144186, 8657103, 1689310, 20068231, 16497976
Y775 Phosphorylation HPRD 15951569, 20068231, 16497976
Y783 Phosphorylation P08631 (HCK) , P00533 (EGFR) , P07949 (RET) , P12931 (SRC) , P43405 (SYK) , P07948 (LYN) HPRD 17016520, 17389395, 7682059, ...8657103, 20068231, 1689310, 8885868, 16497976
T791 Phosphorylation HPRD 20068231
Y977 Phosphorylation HPRD 18083107, 19901323
K1215 Ubiquitination PhosphoSitePlus
S1222 Phosphorylation PhosphoSitePlus
S1225 Phosphorylation PhosphoSitePlus
T1227 Phosphorylation PhosphoSitePlus
S1228 Phosphorylation PhosphoSitePlus
S1234 Phosphorylation PhosphoSitePlus
S1237 Phosphorylation PhosphoSitePlus


P19174 (PLCG1) as PTM Enzyme



Substrate Site Score Source PMID
P38936 (CDKN1A) S146 Signor 31575057


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000048802 (hPLCG1/InitMet-/Phos:2) pY472,pY771,pY783,pY1253 PRO
PR:000048803 (hPLCG1/InitMet-/Phos:3) pY771,pY783 PRO
PR:000048804 (hPLCG1/InitMet-/Phos:4) pY771,pY783,pY1253 PRO
PR:000048805 (hPLCG1/InitMet-/PhosTyr+) p PRO


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation O15117 (FYB1) Y595 P19174 (PLCG1) unknown eFIP 22074159
Phosphorylation O43561 (LAT) Y200 P19174 (PLCG1) unknown eFIP 9489702
Phosphorylation O43561 (LAT) Y161 P19174 (PLCG1) unknown eFIP 10811803
Phosphorylation P00533 (EGFR) Y1092 P19174 (PLCG1) unknown eFIP 7993895
Phosphorylation P00533 (EGFR) Y1016 P19174 (PLCG1) unknown eFIP 16273093
Phosphorylation P00533 (EGFR) Y1197 P19174 (PLCG1) unknown eFIP 7693694
Phosphorylation P04626 (ERBB2) Y1221 P19174 (PLCG1) unknown eFIP 16273093
Phosphorylation P04629 (NTRK1) Y791 P19174 (PLCG1) unknown eFIP 8384556
Phosphorylation P07949 (RET) Y1015 P19174 (PLCG1) unknown eFIP 8628282
Phosphorylation P09619 (PDGFRB) Y1021 P19174 (PLCG1) unknown eFIP 15641795
Phosphorylation P09619 (PDGFRB) Y1009 P19174 (PLCG1) unknown eFIP 1396585
Phosphorylation P09619 (PDGFRB) Y1021 P19174 (PLCG1) unknown eFIP 11896612
Phosphorylation P10721 (KIT) Y936 P19174 (PLCG1) unknown eFIP 7537096
Phosphorylation P11362 (FGFR1) Y766 P19174 (PLCG1) unknown eFIP 1656221
Phosphorylation P11362 (FGFR1) Y766 P19174 (PLCG1) unknown eFIP 8321198
Phosphorylation P16234 (PDGFRA) Y1018 P19174 (PLCG1) unknown eFIP 7535778
Phosphorylation P21860 (ERBB3) Y1276 P19174 (PLCG1) unknown eFIP 16273093
Phosphorylation P30530 (AXL) Y821 P19174 (PLCG1) unknown eFIP 9178760
Phosphorylation P30556 (AGTR1) Y319 P19174 (PLCG1) unknown eFIP 9516477
Phosphorylation P35968 (KDR) Y1008 P19174 (PLCG1) unknown eFIP 12598525
Phosphorylation P43405 (SYK) Y352 P19174 (PLCG1) unknown eFIP 8657103
Phosphorylation P63000 (RAC1) T108 P19174 (PLCG1) inhibited_association eFIP 24043306
Phosphorylation P78314 (SH3BP2) Y183 P19174 (PLCG1) unknown eFIP 11390470
Phosphorylation Q08345 (DDR1) Y484 P19174 (PLCG1) unknown eFIP 22057045
Phosphorylation Q8IZP0 (ABI1) Y421 P19174 (PLCG1) unknown eFIP 20598684


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T237 I237 Biomuta DOID:9256 / colorectal cancer [ tcga ]
Y379 N379 Biomuta DOID:1909 / melanoma [ tcga ]
K389 E389 Biomuta DOID:363 / uterine cancer [ tcga ]
K440 R440 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc, tcga ]
K465 N465 Biomuta DOID:3571 / liver cancer [ icgc ]
S525 T525 Biomuta DOID:363 / uterine cancer [ cosmic, tcga ]
S525 I525 Biomuta DOID:3371 / chondrosarcoma [ cosmic ]
S582 C582 Biomuta DOID:1612 / breast cancer [ cosmic ]
T791 N791 Biomuta DOID:363 / uterine cancer [ tcga ]
Y833 C833 Biomuta DOID:1115 / sarcoma [ tcga ]
Y977 C977 Biomuta DOID:263 / kidney cancer [ tcga ]
S982 F982 Biomuta DOID:1909 / melanoma [ icgc, tcga ]
Y1003 * Biomuta DOID:1793 / pancreatic cancer [ icgc ]
Y1003 S1003 Biomuta DOID:9256 / colorectal cancer [ icgc, tcga ]
R1231 L1231 Biomuta DOID:3571 / liver cancer [ icgc ]
R1243 * Biomuta DOID:363 / uterine cancer [ cosmic, tcga ] DOID:1612 / breast cancer [ icgc, tcga ]
S1273 I1273 Biomuta DOID:3571 / liver cancer [ icgc ]