iPTMnet Report for P19174 (PLCG1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P19174 / PLCG1_HUMAN
Protein Name 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1
Gene Name Name: PLCG1
Synonyms:PLC1;
Organism Homo sapiens (Human)

PRO ID PR:P19174
DAG View
PRO Name 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 (human)
Definition A 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 that is encoded in the genome of human.
Short Label hPLCG1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P19174 (PLCG1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
Phosphorylation PRO
A2 Acetylation UniProt 19413330
S6 Phosphorylation PhosphoSitePlus
K54 Sumoylation PhosphoSitePlus
K54 Ubiquitination PhosphoSitePlus
S63 O-Glycosylation GlyGen 34725712, 29351928
K68 Ubiquitination PhosphoSitePlus
Y93 Phosphorylation PhosphoSitePlus
K159 Ubiquitination PhosphoSitePlus
K175 Ubiquitination PhosphoSitePlus
K178 Ubiquitination PhosphoSitePlus
Y186 Phosphorylation PhosphoSitePlus
Y210 Phosphorylation PhosphoSitePlus
S219 Phosphorylation PhosphoSitePlus
K226 Ubiquitination PhosphoSitePlus
S236 Phosphorylation PhosphoSitePlus
T237 Phosphorylation PhosphoSitePlus
C247 Methylation IEDB 31844290
Y379 Phosphorylation PhosphoSitePlus
K389 Ubiquitination PhosphoSitePlus
S412 Phosphorylation PhosphoSitePlus
Y428 Phosphorylation PhosphoSitePlus
K431 Ubiquitination PhosphoSitePlus
K440 Ubiquitination PhosphoSitePlus
S451 Phosphorylation PhosphoSitePlus
K456 Ubiquitination PhosphoSitePlus
K465 Ubiquitination PhosphoSitePlus
S470 Phosphorylation PhosphoSitePlus
Y472 Phosphorylation P00533 (EGFR) neXtProt   phospho.ELM   PRO   PhosphoSitePlus   Signor 7991458, 1689310, 12601080
T477 Phosphorylation PhosphoSitePlus
Y481 Phosphorylation PhosphoSitePlus   RLIMS-P 23028325
Y496 Phosphorylation PhosphoSitePlus
Y506 Phosphorylation PhosphoSitePlus
Y509 Phosphorylation PhosphoSitePlus
Y518 Phosphorylation PhosphoSitePlus
S525 Phosphorylation PhosphoSitePlus
S539 Phosphorylation PhosphoSitePlus
T542 Phosphorylation PhosphoSitePlus
K549 Ubiquitination PhosphoSitePlus
K554 Ubiquitination PhosphoSitePlus
S582 Phosphorylation PhosphoSitePlus
K666 Ubiquitination PhosphoSitePlus
Y669 Phosphorylation PhosphoSitePlus
Y702 Phosphorylation PhosphoSitePlus
K763 Ubiquitination PhosphoSitePlus
T766 Phosphorylation PhosphoSitePlus
Y771 Phosphorylation P43405 (SYK) , P00519 (ABL1) , P00533 (EGFR) , P07948 (LYN) neXtProt   phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P+   RLIMS-P   Signor   UniProt 12652307, 12601080, 20494825, ...15144186, 1708307, 8657103, 23059825, 29946469, 15592455, 1689310, 19690332, 16038803
Y775 Phosphorylation Q08881 (ITK) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 17420479, 17116690, 29946469, ...15592455, 19690332
Y783 Phosphorylation Q08881 (ITK) , P43403 (ZAP70) , P43405 (SYK) , P07949 (RET) , P00533 (EGFR) , P54764 (EPHA4) neXtProt   phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P   Signor   UniProt 22745786, 17148460, 28798148, ...16467851, 23613900, 15623534, 17494698, 23629676, 23028325, 1689310, 27764189, 29066806, 30873169, 14568990, 25252913, 25140833, 25870599, 19690332, 16153436, 21760611, 12601080, 17420479, 24066087, 15161916, 29972810, 1708307, 16126727, 15764700, 16038803, 27995987, 26295810, 25916191, 22649724, 25734483, 23063561, 9176240, 15215251, 29743977, 28978037, 9716455, 19179337, 25717186, 17220479, 8657103, 22665519, 11564877, 16525023, 16081816, 35367415, 17116690, 24205378
T791 Phosphorylation PhosphoSitePlus
K793 Ubiquitination PhosphoSitePlus
K803 Ubiquitination PhosphoSitePlus
S815 Phosphorylation PhosphoSitePlus
K823 Ubiquitination PhosphoSitePlus
Y833 Phosphorylation PhosphoSitePlus
Y845 Phosphorylation RLIMS-P 17561374
K890 Ubiquitination PhosphoSitePlus
K941 Ubiquitination PhosphoSitePlus
S954 Phosphorylation PhosphoSitePlus
Y959 Phosphorylation PhosphoSitePlus
C976 Methylation IEDB 31844290
Y977 Phosphorylation phospho.ELM   PhosphoSitePlus 18083107
S981 Phosphorylation PhosphoSitePlus
S982 Phosphorylation PhosphoSitePlus
K987 Sumoylation PhosphoSitePlus
Y991 Phosphorylation PhosphoSitePlus
Y1003 Phosphorylation P00519 (ABL1) PhosphoSitePlus 12652307
C1060 S-Nitrosylation dbSNO 26338901
K1079 Ubiquitination PhosphoSitePlus
K1193 Ubiquitination PhosphoSitePlus
S1221 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 19690332, ...20068231
P1222 Phosphorylation UniProt 18669648, 21406692, 19690332
S1224 Phosphorylation PhosphoSitePlus
T1226 Phosphorylation PhosphoSitePlus
S1227 Phosphorylation PhosphoSitePlus   UniProt 23186163
R1231 Methylation PhosphoSitePlus
S1233 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 23186163, 18220336
S1236 Phosphorylation PhosphoSitePlus
R1243 Methylation PhosphoSitePlus
S1248 Phosphorylation P17252 (PRKCA) , P31749 (AKT1) , P17612 (PRKACA) , Q15139 (PRKD1) phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 16525023, 1370476, 28978037, ...28882164
S1251 Phosphorylation PhosphoSitePlus
Y1253 Phosphorylation P43403 (ZAP70) , P00533 (EGFR) neXtProt   phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P   Signor   UniProt 12601080, 17081983, 15161916, ...15144186, 1708307, 22847294, 1689310, 20068231
S1263 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 23186163, 18220336
S1273 Phosphorylation PhosphoSitePlus
R1283 Methylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S6 Phosphorylation HPRD 19413330
Y472 Phosphorylation P00533 (EGFR) HPRD 19901323, 1689310, 12601080
Y481 Phosphorylation HPRD 19901323
S525 Phosphorylation HPRD 19413330
Y771 Phosphorylation P43405 (SYK) , P07948 (LYN) , P08631 (HCK) , P00533 (EGFR) HPRD 17016520, 17389395, 7682059, ...15144186, 8657103, 1689310, 20068231, 16497976
Y775 Phosphorylation HPRD 15951569, 20068231, 16497976
Y783 Phosphorylation P07949 (RET) , P12931 (SRC) , P00533 (EGFR) , P43405 (SYK) , P08631 (HCK) , P07948 (LYN) HPRD 17016520, 17389395, 7682059, ...8657103, 20068231, 1689310, 8885868, 16497976
T791 Phosphorylation HPRD 20068231
Y977 Phosphorylation HPRD 18083107, 19901323
S1221 Phosphorylation HPRD 18669648, 19664994, 20068231
S1233 Phosphorylation HPRD 20068231
S1248 Phosphorylation Q15139 (PRKD1) HPRD 19651622, 20068231, 8885868
Y1253 Phosphorylation P08631 (HCK) HPRD 17016520, 17389395, 7682059, ...15144186, 20068231, 18707149, 8885868
S1263 Phosphorylation HPRD 18077418
Site PTM Type PTM Enzyme Score Source PMID
S6 Phosphorylation HPRD 19413330
Y472 Phosphorylation P00533 (EGFR) HPRD 19901323, 1689310, 12601080
Y481 Phosphorylation HPRD 19901323
S525 Phosphorylation HPRD 19413330
Y771 Phosphorylation P08631 (HCK) , P00533 (EGFR) , P43405 (SYK) , P07948 (LYN) HPRD 17016520, 17389395, 7682059, ...15144186, 8657103, 1689310, 20068231, 16497976
Y775 Phosphorylation HPRD 15951569, 20068231, 16497976
Y783 Phosphorylation P08631 (HCK) , P00533 (EGFR) , P07949 (RET) , P12931 (SRC) , P43405 (SYK) , P07948 (LYN) HPRD 17016520, 17389395, 7682059, ...8657103, 20068231, 1689310, 8885868, 16497976
T791 Phosphorylation HPRD 20068231
Y977 Phosphorylation HPRD 18083107, 19901323
K1215 Ubiquitination PhosphoSitePlus
S1222 Phosphorylation PhosphoSitePlus
S1225 Phosphorylation PhosphoSitePlus
T1227 Phosphorylation PhosphoSitePlus
S1228 Phosphorylation PhosphoSitePlus
S1234 Phosphorylation PhosphoSitePlus
S1237 Phosphorylation PhosphoSitePlus


P19174 (PLCG1) as PTM Enzyme



Substrate Site Score Source PMID
P38936 (CDKN1A) S146 Signor 31575057


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000048802 (hPLCG1/InitMet-/Phos:2) pY472,pY771,pY783,pY1253 PRO
PR:000048803 (hPLCG1/InitMet-/Phos:3) pY771,pY783 PRO
PR:000048804 (hPLCG1/InitMet-/Phos:4) pY771,pY783,pY1253 PRO
PR:000048805 (hPLCG1/InitMet-/PhosTyr+) p PRO


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation P63000 (RAC1) T108 P19174 (PLCG1) inhibited_association eFIP 24043306


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T237 I237 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
K389 E389 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K440 R440 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
Y496 F496 Biomuta DOID:1612 / breast cancer [ cosmic ]
Y509 H509 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
S525 T525 Biomuta DOID:363 / uterine cancer [ cosmic ]
S525 I525 Biomuta DOID:184 / bone cancer [ cosmic ]
S582 C582 Biomuta DOID:1793 / pancreatic cancer [ cosmic ] DOID:1612 / breast cancer [ cosmic ]
Y771 * Biomuta DOID:4159 / skin cancer [ cosmic ]
Y775 F775 Biomuta DOID:1612 / breast cancer [ cosmic ]
T791 N791 Biomuta DOID:363 / uterine cancer [ icgc ]
T791 P791 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
Y833 C833 Biomuta [ cosmic ] DOID:1115 / sarcoma [ icgc ]
K890 R890 Biomuta DOID:4159 / skin cancer [ cosmic ]
Y977 C977 Biomuta DOID:263 / kidney cancer [ cosmic, icgc ]
S982 F982 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
Y1003 S1003 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
P1222 S1222 Biomuta DOID:4159 / skin cancer [ cosmic ]
T1226 M1226 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic ]
T1227 M1227 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic ]
S1233 * Biomuta DOID:4159 / skin cancer [ cosmic ]
S1234 * Biomuta DOID:184 / bone cancer [ cosmic ] DOID:1612 / breast cancer [ cosmic ] DOID:4159 / skin cancer [ cosmic, cosmic ] DOID:9256 / colorectal cancer [ cosmic ] DOID:363 / uterine cancer [ cosmic, icgc ] DOID:263 / kidney cancer [ cosmic, icgc ]
R1243 * Biomuta DOID:363 / uterine cancer [ cosmic ] DOID:1612 / breast cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic ]
R1283 Q1283 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]