Protein Information

Cytoscape View

UniProt AC / UniProt ID P19105 / ML12A_HUMAN
Protein Name Myosin regulatory light chain 12A
Gene Name Name: MYL12A
Organism Homo sapiens (Human)

PRO ID PR:P19105
DAG View
PRO Name myosin regulatory light chain 12A (human)
Definition A myosin regulatory light chain MRLC3 that is encoded in the genome of human.
Short Label hMYL12A
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species

P19105 (MYL12A) as Substrate

Site PTM Type PTM Enzyme Score Source PMID
T10 Phosphorylation PhosphoSitePlus
T18 Phosphorylation Q13464 (ROCK1) HPRD   phospho.ELM   PhosphoSitePlus   UniProt 11942626, 12185584, 17924679
S19 Phosphorylation P53355-3 (DAPK1) , Q13177 (PAK2) , Q13464 (ROCK1) HPRD   neXtProt   phospho.ELM   PRO   PhosphoSitePlus   UniProt 11942626, 11485996, 10047984, ...12185584, 19415658, 17924679
S28 Phosphorylation PhosphoSitePlus
K34 Acetylation PhosphoSitePlus
K50 Acetylation PhosphoSitePlus
K50 Ubiquitination PhosphoSitePlus
S59 Phosphorylation HPRD   PhosphoSitePlus 20068231
T96 Phosphorylation PhosphoSitePlus
T127 Phosphorylation HPRD   PhosphoSitePlus 20068231
R132 Methylation PhosphoSitePlus
T134 Phosphorylation PhosphoSitePlus
Y142 Phosphorylation PhosphoSitePlus
K149 Ubiquitination PhosphoSitePlus
K150 Sumoylation PhosphoSitePlus
K150 Ubiquitination PhosphoSitePlus
Y155 Phosphorylation PhosphoSitePlus
K163 Ubiquitination PhosphoSitePlus


PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000048495 (hMYL12A/Phos:1) pS19 PRO

PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S28 L28 Biomuta DOID:1612 / breast cancer [ cosmic, icgc, tcga ]
T127 P127 Biomuta DOID:363 / uterine cancer [ tcga ]
R132 Q132 Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
K149 * Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc, tcga ]