iPTMnet Report for P19022 (CDH2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P19022 / CADH2_HUMAN
Protein Name Cadherin-2 precursor
Gene Name Name: CDH2
Synonyms:CDHN,NCAD;
Organism Homo sapiens (Human)

PRO ID PR:P19022
DAG View
PRO Name cadherin-2 (human)
Definition A cadherin-2 that is encoded in the genome of human.
Short Label hCDH2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P19022 (CDH2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S61 Phosphorylation PhosphoSitePlus
S96 Phosphorylation UniProt 26091039
S135 Phosphorylation PhosphoSitePlus   UniProt 26091039
N273 N-Glycosylation GlyGen   UniProt 19159218, 23345538
N324 N-Glycosylation GlyGen 24190977
N325 N-Glycosylation GlyGen 24190977
N402 N-Glycosylation GlyGen   UniProt 19159218, 29391424, 24190977
K448 Ubiquitination PhosphoSitePlus
T454 Phosphorylation PhosphoSitePlus
Y496 Phosphorylation PhosphoSitePlus
K536 Ubiquitination PhosphoSitePlus
N572 N-Glycosylation GlyGen   UniProt 19159218
N651 N-Glycosylation GlyGen 23090970, 29391424, 24190977
K667 Ubiquitination PhosphoSitePlus
T683 Phosphorylation PhosphoSitePlus
S685 Phosphorylation PhosphoSitePlus
N687 N-Glycosylation GlyGen 24190977
S691 O-Glycosylation GlyGen 23271734, 34019948, 35254053
N692 N-Glycosylation GlyGen   UniProt 23090970, 19159218, 29391424, ...24190977
K756 Ubiquitination PhosphoSitePlus
K772 Ubiquitination PhosphoSitePlus
Y773 Phosphorylation PhosphoSitePlus
Y785 Phosphorylation phospho.ELM   PhosphoSitePlus 16212419
S788 Phosphorylation PhosphoSitePlus
K802 Ubiquitination PhosphoSitePlus
Y820 Phosphorylation P12931 (SRC) PhosphoSitePlus 16371504
S824 Phosphorylation PhosphoSitePlus
Y852 Phosphorylation P12931 (SRC) phospho.ELM   PhosphoSitePlus   Signor 16371504
Y860 Phosphorylation P12931 (SRC) PhosphoSitePlus   RLIMS-P   Signor 16371504, 23292232
Y884 Phosphorylation P12931 (SRC) phospho.ELM   PhosphoSitePlus   Signor 16371504
Y886 Phosphorylation P12931 (SRC) PhosphoSitePlus   Signor 16371504
Site PTM Type PTM Enzyme Score Source PMID
S135 Phosphorylation HPRD 18702456
N273 N-Glycosylation PRO 23345538
Y785 Phosphorylation HPRD 16212419
S788 Phosphorylation HPRD 18077418


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S61 C61 Biomuta DOID:3571 / liver cancer [ cosmic, icgc ]
T454 K454 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
Y496 N496 Biomuta DOID:1324 / lung cancer [ cosmic ]
K536 N536 Biomuta DOID:4159 / skin cancer [ cosmic ]
S685 L685 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S691 L691 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
S788 C788 Biomuta DOID:1324 / lung cancer [ tcga ]
K802 T802 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
Y860 H860 Biomuta DOID:4159 / skin cancer [ cosmic ]
Y860 C860 Biomuta DOID:1324 / lung cancer [ cosmic ]
Y886 S886 Biomuta DOID:10534 / stomach cancer [ cosmic ]