iPTMnet Report for P18858 (LIG1)
Protein Information
UniProt AC / UniProt ID | P18858 / DNLI1_HUMAN |
Protein Name | DNA ligase 1 |
Gene Name | Name: LIG1 |
Organism | Homo sapiens (Human) |
PRO ID | PR:P18858 |
PRO Name | DNA ligase 1 (human) |
Definition | A DNA ligase 1 that is encoded in the genome of human. |
Short Label | hLIG1 |
Category | organism-gene |
P18858 (LIG1) as Substrate
Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
---|---|---|---|---|---|---|
S4 | Phosphorylation | score1 | PhosphoSitePlus | |||
K40 | Ubiquitination | score1 | PhosphoSitePlus | |||
S47 | Phosphorylation | score2 | phospho.ELM PhosphoSitePlus UniProt | 18669648, 23186163, 17081983, ... | ||
S49 | Phosphorylation | score2 | phospho.ELM PhosphoSitePlus UniProt | 17081983, 20068231, 19690332 | ||
S51 | Phosphorylation | score4 | phospho.ELM PhosphoSitePlus Signor UniProt | 21406692, 23186163, 16964243, ... | ||
S51 | Phosphorylation | P24941 (CDK2) | score3 | PhosphoSitePlus Signor | 12851383 | |
S66 | Phosphorylation | score4 | phospho.ELM PhosphoSitePlus Signor UniProt | 21406692, 23186163, 16964243, ... | ||
S66 | Phosphorylation | P68400 (CSNK2A1) | score4 | PhosphoSitePlus Signor | 10523317, 12851383 | |
S76 | Phosphorylation | score4 | phospho.ELM PhosphoSitePlus Signor UniProt | 21406692, 23186163, 16964243, ... | ||
S76 | Phosphorylation | O14757 (CHEK1) | score1 | PhosphoSitePlus | 21851590 | |
S76 | Phosphorylation | P06493 (CDK1) | score4 | PhosphoSitePlus Signor | 18234856, 12851383 | |
S76 | Phosphorylation | P24941 (CDK2) | score4 | PhosphoSitePlus Signor | 18847512, 12851383 | |
K79 | Ubiquitination | score1 | PhosphoSitePlus | |||
S88 | Phosphorylation | score1 | phospho.ELM | 18669648 | ||
S91 | Phosphorylation | score3 | PhosphoSitePlus Signor | 12851383 | ||
S91 | Phosphorylation | P24941 (CDK2) | score3 | PhosphoSitePlus Signor | 12851383 | |
T97 | Phosphorylation | score2 | phospho.ELM PhosphoSitePlus | 18669648 | ||
S98 | Phosphorylation | score1 | PhosphoSitePlus | |||
S109 | Phosphorylation | score1 | PhosphoSitePlus | |||
S114 | Phosphorylation | score1 | phospho.ELM | 18669648 | ||
S141 | Phosphorylation | score2 | phospho.ELM PhosphoSitePlus UniProt | 21406692, 23186163, 17081983, ... | ||
R146 | Methylation | score1 | PhosphoSitePlus | |||
S163 | Phosphorylation | score1 | PhosphoSitePlus | |||
T165 | Phosphorylation | score1 | PhosphoSitePlus | |||
T171 | Phosphorylation | score1 | PhosphoSitePlus | |||
T182 | Phosphorylation | score1 | PhosphoSitePlus | |||
T183 | Phosphorylation | score2 | phospho.ELM PhosphoSitePlus | 18669648 | ||
T190 | Phosphorylation | score1 | PhosphoSitePlus | |||
K192 | Ubiquitination | score1 | PhosphoSitePlus | |||
T195 | Phosphorylation | score2 | phospho.ELM PhosphoSitePlus UniProt | 21406692, 23186163, 16964243, ... | ||
T195 | Phosphorylation | P24941 (CDK2) | score1 | PhosphoSitePlus | 18847512 | |
T197 | Phosphorylation | score2 | phospho.ELM PhosphoSitePlus | 18669648, 18847512 | ||
T197 | Phosphorylation | P24941 (CDK2) | score1 | PhosphoSitePlus | 18847512 | |
S199 | Phosphorylation | score2 | PhosphoSitePlus UniProt | 23186163 | ||
S201 | Phosphorylation | score2 | phospho.ELM PhosphoSitePlus UniProt | 23186163, 17081983, 18669648, ... | ||
T207 | Phosphorylation | score2 | PhosphoSitePlus UniProt | 23186163 | ||
K219 | Acetylation | score1 | PhosphoSitePlus | |||
K219 | Ubiquitination | score1 | PhosphoSitePlus | |||
K226 | Ubiquitination | score1 | PhosphoSitePlus | |||
S229 | Phosphorylation | score2 | PhosphoSitePlus UniProt | 23186163 | ||
S230 | Phosphorylation | score2 | PhosphoSitePlus UniProt | 23186163 | ||
T233 | Phosphorylation | score2 | phospho.ELM PhosphoSitePlus UniProt | 17081983, 18220336, 18847512, ... | ||
T233 | Phosphorylation | P24941 (CDK2) | score1 | PhosphoSitePlus | 18847512 | |
K240 | Sumoylation | score1 | PhosphoSitePlus | |||
K244 | Sumoylation | score1 | PhosphoSitePlus | |||
K244 | Ubiquitination | score1 | PhosphoSitePlus | |||
K270 | Ubiquitination | score1 | PhosphoSitePlus | |||
K282 | Ubiquitination | score1 | PhosphoSitePlus | |||
K286 | Ubiquitination | score1 | PhosphoSitePlus | |||
K298 | Ubiquitination | score1 | PhosphoSitePlus | |||
T311 | Phosphorylation | score1 | PhosphoSitePlus | |||
S313 | Phosphorylation | score1 | PhosphoSitePlus | |||
K376 | Ubiquitination | score1 | PhosphoSitePlus | |||
K407 | Ubiquitination | score1 | PhosphoSitePlus | |||
K422 | Ubiquitination | score1 | PhosphoSitePlus | |||
K428 | Ubiquitination | score1 | PhosphoSitePlus | |||
S437 | Phosphorylation | score1 | PhosphoSitePlus | |||
S445 | Phosphorylation | score1 | PhosphoSitePlus | |||
S447 | Phosphorylation | score1 | PhosphoSitePlus | |||
K493 | Ubiquitination | score1 | PhosphoSitePlus | |||
T506 | Phosphorylation | score1 | PhosphoSitePlus | |||
C532 | Methylation | score1 | IEDB | 31844290 | ||
K533 | Ubiquitination | score1 | PhosphoSitePlus | |||
S535 | Phosphorylation | score1 | PhosphoSitePlus | |||
K541 | Ubiquitination | score1 | PhosphoSitePlus | |||
T548 | Phosphorylation | score1 | PhosphoSitePlus | |||
S552 | Phosphorylation | score1 | PhosphoSitePlus | |||
K556 | Ubiquitination | score1 | PhosphoSitePlus | |||
C565 | Methylation | score1 | IEDB | 31844290 | ||
K568 | Ubiquitination | score1 | PhosphoSitePlus | |||
K585 | Ubiquitination | score1 | PhosphoSitePlus | |||
K597 | Ubiquitination | score1 | PhosphoSitePlus | |||
K630 | Sumoylation | score1 | PhosphoSitePlus | |||
K630 | Ubiquitination | score1 | PhosphoSitePlus | |||
T639 | Phosphorylation | score1 | PhosphoSitePlus | |||
S714 | Phosphorylation | score1 | PhosphoSitePlus | |||
C719 | Methylation | score1 | IEDB | 31844290 | ||
K737 | Ubiquitination | score1 | PhosphoSitePlus | |||
K744 | Ubiquitination | score1 | PhosphoSitePlus | |||
K795 | Methylation | score1 | PhosphoSitePlus | |||
K795 | Ubiquitination | score1 | PhosphoSitePlus | |||
T798 | Phosphorylation | score2 | PhosphoSitePlus UniProt | 23186163 | ||
S801 | Phosphorylation | score2 | PhosphoSitePlus UniProt | 23186163 | ||
K813 | Ubiquitination | score1 | PhosphoSitePlus | |||
S819 | Phosphorylation | score2 | PhosphoSitePlus UniProt | 23186163 | ||
Y823 | Phosphorylation | score1 | PhosphoSitePlus | |||
K866 | Ubiquitination | score1 | PhosphoSitePlus | |||
Y897 | Phosphorylation | score1 | PhosphoSitePlus | |||
S911 | Phosphorylation | score2 | phospho.ELM PhosphoSitePlus UniProt | 18669648, 15302935, 19690332, ... | ||
S913 | Phosphorylation | score2 | phospho.ELM PhosphoSitePlus UniProt | 18669648, 19690332 | ||
T918 | Phosphorylation | score1 | PhosphoSitePlus | |||
Y919 | Phosphorylation | score1 | PhosphoSitePlus |
Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
---|---|---|---|---|---|---|
S47 | Phosphorylation | score0 | HPRD | 19413330, 18669648, 17081983, ... | ||
S49 | Phosphorylation | score0 | HPRD | 19651622, 17081983, 20068231, ... | ||
S51 | Phosphorylation | score0 | HPRD | 19413330, 17322306, 16964243, ... | ||
S66 | Phosphorylation | score2 | HPRD | 19413330, 20058876, 20230923, ... | ||
S66 | Phosphorylation | P68400 (CSNK2A1) | score2 | HPRD | 19413330, 20058876, 20230923, ... | |
S76 | Phosphorylation | score0 | HPRD | 19413330, 17322306, 16964243, ... | ||
S88 | Phosphorylation | score0 | HPRD | 18669648 | ||
T97 | Phosphorylation | score0 | HPRD | 18669648 | ||
S114 | Phosphorylation | score0 | HPRD | 18669648 | ||
S141 | Phosphorylation | score0 | HPRD | 17322306, 19664994, 19664995, ... | ||
T182 | Phosphorylation | score0 | HPRD | 17322306, 19651622, 20068231 | ||
T183 | Phosphorylation | score0 | HPRD | 17322306, 18212344, 18767875, ... | ||
T195 | Phosphorylation | score0 | HPRD | 19413330, 17322306, 16964243, ... | ||
T197 | Phosphorylation | score0 | HPRD | 17322306, 18669648, 20058876, ... | ||
S199 | Phosphorylation | score0 | HPRD | 19413330 | ||
S201 | Phosphorylation | score0 | HPRD | 19413330, 17081983, 19664994, ... | ||
T227 | Phosphorylation | score0 | HPRD | 20068231 | ||
S230 | Phosphorylation | score0 | HPRD | 17924679 | ||
T233 | Phosphorylation | score0 | HPRD | 17081983, 18669648, 19664995, ... | ||
T311 | Phosphorylation | score0 | HPRD | 20068231 | ||
S313 | Phosphorylation | score0 | HPRD | 20068231 | ||
S535 | Phosphorylation | score0 | HPRD | 20068231 | ||
T548 | Phosphorylation | score0 | HPRD | 20068231 | ||
S714 | Phosphorylation | score0 | HPRD | 20068231 | ||
S911 | Phosphorylation | score0 | HPRD | 19413330, 15302935, 18452278, ... | ||
S913 | Phosphorylation | score0 | HPRD | 19413330, 18452278, 19651622, ... | ||
T918 | Phosphorylation | score0 | HPRD | 19651622 | ||
Y919 | Phosphorylation | score0 | HPRD | 19651622 |
PTM-dependent PPI
PTM type | Substrate | Site | Interactant | Association type | Source | PMID | |
---|---|---|---|---|---|---|---|
Phosphorylation | Q96T88 (UHRF1) | S298 | P18858 (LIG1) | unknown | eFIP | 32428527 |