iPTMnet Report for P18858 (LIG1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P18858 / DNLI1_HUMAN
Protein Name DNA ligase 1
Gene Name Name: LIG1
Organism Homo sapiens (Human)

PRO ID PR:P18858
DAG View
PRO Name DNA ligase 1 (human)
Definition A DNA ligase 1 that is encoded in the genome of human.
Short Label hLIG1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P18858 (LIG1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S4 Phosphorylation PhosphoSitePlus
K40 Ubiquitination PhosphoSitePlus
S47 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 17081983, ...20068231
S49 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 17081983, 20068231, 19690332
S51 Phosphorylation phospho.ELM   PhosphoSitePlus   Signor   UniProt 21406692, 23186163, 16964243, ...12851383, 18669648, 19690332, 20068231, 17081983
S51 Phosphorylation P24941 (CDK2) PhosphoSitePlus   Signor 12851383
S66 Phosphorylation phospho.ELM   PhosphoSitePlus   Signor   UniProt 21406692, 23186163, 16964243, ...12851383, 18669648, 17693683, 10523317, 19690332, 20068231, 17081983
S66 Phosphorylation P68400 (CSNK2A1) PhosphoSitePlus   Signor 10523317, 12851383
S76 Phosphorylation phospho.ELM   PhosphoSitePlus   Signor   UniProt 21406692, 23186163, 16964243, ...12851383, 18847512, 18234856, 15302935, 18669648, 21851590, 17693683, 20068231, 17081983
S76 Phosphorylation O14757 (CHEK1) PhosphoSitePlus 21851590
S76 Phosphorylation P06493 (CDK1) PhosphoSitePlus   Signor 18234856, 12851383
S76 Phosphorylation P24941 (CDK2) PhosphoSitePlus   Signor 18847512, 12851383
K79 Ubiquitination PhosphoSitePlus
S88 Phosphorylation phospho.ELM 18669648
S91 Phosphorylation PhosphoSitePlus   Signor 12851383
S91 Phosphorylation P24941 (CDK2) PhosphoSitePlus   Signor 12851383
T97 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S98 Phosphorylation PhosphoSitePlus
S109 Phosphorylation PhosphoSitePlus
S114 Phosphorylation phospho.ELM 18669648
S141 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 17081983, ...15302935, 18669648, 19690332, 20068231
R146 Methylation PhosphoSitePlus
S163 Phosphorylation PhosphoSitePlus
T165 Phosphorylation PhosphoSitePlus
T171 Phosphorylation PhosphoSitePlus
T182 Phosphorylation PhosphoSitePlus
T183 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
T190 Phosphorylation PhosphoSitePlus
K192 Ubiquitination PhosphoSitePlus
T195 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 16964243, ...18847512, 15302935, 18669648, 19690332, 20068231, 17081983
T195 Phosphorylation P24941 (CDK2) PhosphoSitePlus 18847512
T197 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648, 18847512
T197 Phosphorylation P24941 (CDK2) PhosphoSitePlus 18847512
S199 Phosphorylation PhosphoSitePlus   UniProt 23186163
S201 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 23186163, 17081983, 18669648, ...19690332, 20068231
T207 Phosphorylation PhosphoSitePlus   UniProt 23186163
K219 Acetylation PhosphoSitePlus
K219 Ubiquitination PhosphoSitePlus
K226 Ubiquitination PhosphoSitePlus
S229 Phosphorylation PhosphoSitePlus   UniProt 23186163
S230 Phosphorylation PhosphoSitePlus   UniProt 23186163
T233 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 17081983, 18220336, 18847512, ...18669648, 16964243
T233 Phosphorylation P24941 (CDK2) PhosphoSitePlus 18847512
K240 Sumoylation PhosphoSitePlus
K244 Sumoylation PhosphoSitePlus
K244 Ubiquitination PhosphoSitePlus
K270 Ubiquitination PhosphoSitePlus
K282 Ubiquitination PhosphoSitePlus
K286 Ubiquitination PhosphoSitePlus
K298 Ubiquitination PhosphoSitePlus
T311 Phosphorylation PhosphoSitePlus
S313 Phosphorylation PhosphoSitePlus
K376 Ubiquitination PhosphoSitePlus
K407 Ubiquitination PhosphoSitePlus
K422 Ubiquitination PhosphoSitePlus
K428 Ubiquitination PhosphoSitePlus
S437 Phosphorylation PhosphoSitePlus
S445 Phosphorylation PhosphoSitePlus
S447 Phosphorylation PhosphoSitePlus
K493 Ubiquitination PhosphoSitePlus
T506 Phosphorylation PhosphoSitePlus
C532 Methylation IEDB 31844290
K533 Ubiquitination PhosphoSitePlus
S535 Phosphorylation PhosphoSitePlus
K541 Ubiquitination PhosphoSitePlus
T548 Phosphorylation PhosphoSitePlus
S552 Phosphorylation PhosphoSitePlus
K556 Ubiquitination PhosphoSitePlus
C565 Methylation IEDB 31844290
K568 Ubiquitination PhosphoSitePlus
K585 Ubiquitination PhosphoSitePlus
K597 Ubiquitination PhosphoSitePlus
K630 Sumoylation PhosphoSitePlus
K630 Ubiquitination PhosphoSitePlus
T639 Phosphorylation PhosphoSitePlus
S714 Phosphorylation PhosphoSitePlus
C719 Methylation IEDB 31844290
K737 Ubiquitination PhosphoSitePlus
K744 Ubiquitination PhosphoSitePlus
K795 Methylation PhosphoSitePlus
K795 Ubiquitination PhosphoSitePlus
T798 Phosphorylation PhosphoSitePlus   UniProt 23186163
S801 Phosphorylation PhosphoSitePlus   UniProt 23186163
K813 Ubiquitination PhosphoSitePlus
S819 Phosphorylation PhosphoSitePlus   UniProt 23186163
Y823 Phosphorylation PhosphoSitePlus
K866 Ubiquitination PhosphoSitePlus
Y897 Phosphorylation PhosphoSitePlus
S911 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 15302935, 19690332, ...20068231
S913 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 19690332
T918 Phosphorylation PhosphoSitePlus
Y919 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S47 Phosphorylation HPRD 19413330, 18669648, 17081983, ...20068231
S49 Phosphorylation HPRD 19651622, 17081983, 20068231, ...19664995
S51 Phosphorylation HPRD 19413330, 17322306, 16964243, ...20058876, 19664994, 19664995, 18452278, 19651622, 18669648, 18767875, 20068231
S66 Phosphorylation HPRD 19413330, 20058876, 20230923, ...18767875, 15302935, 19664995, 18452278, 19651622, 19664994, 18669648, 17693683, 10523317, 19415658, 20068231
S66 Phosphorylation P68400 (CSNK2A1) HPRD 19413330, 20058876, 20230923, ...18767875, 15302935, 19664995, 18452278, 19651622, 19664994, 18669648, 17693683, 10523317, 19415658, 20068231
S76 Phosphorylation HPRD 19413330, 17322306, 16964243, ...20230923, 18767875, 20058876, 19664995, 18452278, 19651622, 19664994, 18669648, 17693683, 19415658, 20068231
S88 Phosphorylation HPRD 18669648
T97 Phosphorylation HPRD 18669648
S114 Phosphorylation HPRD 18669648
S141 Phosphorylation HPRD 17322306, 19664994, 19664995, ...18452278, 19651622, 18669648, 20068231
T182 Phosphorylation HPRD 17322306, 19651622, 20068231
T183 Phosphorylation HPRD 17322306, 18212344, 18767875, ...18452278, 19651622, 18669648, 20068231
T195 Phosphorylation HPRD 19413330, 17322306, 16964243, ...20058876, 19664994, 19664995, 18452278, 19651622, 18669648, 18767875, 20068231
T197 Phosphorylation HPRD 17322306, 18669648, 20058876, ...19664995, 20068231
S199 Phosphorylation HPRD 19413330
S201 Phosphorylation HPRD 19413330, 17081983, 19664994, ...19664995, 19651622, 18669648, 20068231
T227 Phosphorylation HPRD 20068231
S230 Phosphorylation HPRD 17924679
T233 Phosphorylation HPRD 17081983, 18669648, 19664995, ...16964243
T311 Phosphorylation HPRD 20068231
S313 Phosphorylation HPRD 20068231
S535 Phosphorylation HPRD 20068231
T548 Phosphorylation HPRD 20068231
S714 Phosphorylation HPRD 20068231
S911 Phosphorylation HPRD 19413330, 15302935, 18452278, ...19651622, 18669648, 19415658, 20068231
S913 Phosphorylation HPRD 19413330, 18452278, 19651622, ...18669648, 19415658, 20068231
T918 Phosphorylation HPRD 19651622
Y919 Phosphorylation HPRD 19651622


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation Q96T88 (UHRF1) S298 P18858 (LIG1) unknown eFIP 32428527


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S4 N4 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
S47 T47 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S51 A51 Biomuta DOID:4159 / skin cancer [ cosmic ]
S141 N141 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
S141 G141 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
R146 * Biomuta DOID:263 / kidney cancer [ cosmic ]
S163 N163 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
T183 M183 Biomuta DOID:1793 / pancreatic cancer [ cosmic, icgc ] DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ] DOID:9256 / colorectal cancer [ cosmic ]
K192 N192 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
T207 S207 Biomuta DOID:1324 / lung cancer [ cosmic ]
T227 M227 Biomuta DOID:9256 / colorectal cancer [ cosmic ] DOID:5041 / esophageal cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic, icgc ]
K270 N270 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
T311 M311 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
T311 K311 Biomuta DOID:3571 / liver cancer [ cosmic ]
K422 R422 Biomuta DOID:4159 / skin cancer [ cosmic ]
S437 * Biomuta DOID:363 / uterine cancer [ cosmic ]
C565 W565 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
K585 N585 Biomuta DOID:263 / kidney cancer [ cosmic, icgc ]
K737 R737 Biomuta DOID:5041 / esophageal cancer [ cosmic ]
S819 I819 Biomuta DOID:10283 / prostate cancer [ cosmic ]
K866 N866 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S913 C913 Biomuta DOID:4362 / cervical cancer [ cosmic, icgc ]