Protein Information

Cytoscape View

UniProt AC / UniProt ID P18848 / ATF4_HUMAN
Protein Name Cyclic AMP-dependent transcription factor ATF-4
Gene Name Name: ATF4
Organism Homo sapiens (Human)

PRO ID PR:P18848
DAG View
PRO Name cyclic AMP-dependent transcription factor ATF-4 (human)
Definition A cyclic AMP-dependent transcription factor ATF-4 that is encoded in the genome of human.
Short Label hATF4
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species

P18848 (ATF4) as Substrate

Site PTM Type PTM Enzyme Score Source PMID
K45 Sumoylation PhosphoSitePlus
K45 Ubiquitination PhosphoSitePlus
K53 Sumoylation PhosphoSitePlus
K53 Ubiquitination PhosphoSitePlus
K55 Ubiquitination PhosphoSitePlus
S69 Phosphorylation HPRD   PhosphoSitePlus 19413330, 20068231
K75 Ubiquitination PhosphoSitePlus
K88 Ubiquitination PhosphoSitePlus
T107 Phosphorylation P07949 (RET) PhosphoSitePlus 25795775
T114 Phosphorylation P07949 (RET) PhosphoSitePlus 25795775
T115 Phosphorylation P07949 (RET) PhosphoSitePlus 25795775
T119 Phosphorylation P07949 (RET) PhosphoSitePlus 25795775
S215 Phosphorylation PhosphoSitePlus   RLIMS-P   UniProt 23123191
S219 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P 17996332, 11238952
S224 Phosphorylation PhosphoSitePlus   RLIMS-P 17996332
S245 Phosphorylation P51812 (RPS6KA3) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 22052162, 27321283, 15109498, ...23975372, 30424508
S248 Phosphorylation PhosphoSitePlus
K259 Ubiquitination PhosphoSitePlus
K267 Sumoylation PhosphoSitePlus
K267 Ubiquitination PhosphoSitePlus
K277 Ubiquitination PhosphoSitePlus
T293 Phosphorylation PhosphoSitePlus
Y295 Phosphorylation PhosphoSitePlus
K299 Ubiquitination PhosphoSitePlus
K311 Acetylation PR:000007102 (EP300) PRO   UniProt 16219772
K329 Ubiquitination PhosphoSitePlus
K335 Ubiquitination PhosphoSitePlus
K343 Acetylation PhosphoSitePlus
K348 Acetylation PhosphoSitePlus


PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000028557 (hATF4/Ac:1) acK311 PR:000007102 (EP300) PRO 16219772

PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S69 I69 Biomuta DOID:10283 / prostate cancer [ cosmic ]
K88 E88 Biomuta DOID:1793 / pancreatic cancer [ icgc ]
S215 L215 Biomuta DOID:1909 / melanoma [ icgc, tcga ]