Protein Information

Cytoscape View


UniProt AC / UniProt ID P18827 / SDC1_HUMAN
Protein Name Syndecan-1 precursor
Gene Name Name: SDC1
Synonyms:SDC;
Organism Homo sapiens (Human)

PRO ID PR:P18827
DAG View
PRO Name syndecan-1 (human)
Definition A syndecan-1 that is encoded in the genome of human.
Short Label hSDC1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P18827 (SDC1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
T61 O-Glycosylation PhosphoSitePlus
T72 O-Glycosylation PhosphoSitePlus
T76 O-Glycosylation PhosphoSitePlus
S77 O-Glycosylation PhosphoSitePlus
T81 O-Glycosylation PhosphoSitePlus
T122 O-Glycosylation PhosphoSitePlus
T164 O-Glycosylation PhosphoSitePlus
S165 O-Glycosylation PhosphoSitePlus
T166 O-Glycosylation PhosphoSitePlus
S171 O-Glycosylation PhosphoSitePlus
T177 O-Glycosylation PhosphoSitePlus
T180 O-Glycosylation PhosphoSitePlus
S186 O-Glycosylation PhosphoSitePlus
T188 O-Glycosylation PhosphoSitePlus
T240 O-Glycosylation PhosphoSitePlus
K280 Ubiquitination PhosphoSitePlus
K281 Ubiquitination PhosphoSitePlus
S285 Phosphorylation PhosphoSitePlus   UniProt 23186163
Y286 Phosphorylation HPRD   PhosphoSitePlus 19901323
S287 Phosphorylation PhosphoSitePlus
K292 Ubiquitination PhosphoSitePlus
Y299 Phosphorylation HPRD   PhosphoSitePlus 19901323
K301 Ubiquitination PhosphoSitePlus
K304 Ubiquitination PhosphoSitePlus
Y309 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18083107, 19901323


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T72 M72 Biomuta DOID:1793 / pancreatic cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
T76 M76 Biomuta DOID:9256 / colorectal cancer [ icgc ]
T122 N122 Biomuta DOID:3571 / liver cancer [ icgc ]
T164 S164 Biomuta DOID:4362 / cervical cancer [ cosmic, icgc, tcga ]
T240 A240 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ]
S287 Y287 Biomuta DOID:1324 / lung cancer [ tcga ]
S287 F287 Biomuta DOID:1909 / melanoma [ tcga ]
Y299 C299 Biomuta DOID:3571 / liver cancer [ icgc ]
Y299 F299 Biomuta DOID:1324 / lung cancer [ cosmic, icgc, tcga ]