Protein Information

Cytoscape View

UniProt AC / UniProt ID P18669 / PGAM1_HUMAN
Protein Name Phosphoglycerate mutase 1
Gene Name Name: PGAM1
Organism Homo sapiens (Human)

PRO ID PR:P18669
DAG View
PRO Name phosphoglycerate mutase 1 (human)
Definition A phosphoglycerate mutase 1 that is encoded in the genome of human.
Short Label hPGAM1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species

P18669 (PGAM1) as Substrate

Site PTM Type PTM Enzyme Score Source PMID
K5 Acetylation PhosphoSitePlus
K5 Methylation PhosphoSitePlus
K5 Ubiquitination PhosphoSitePlus
H11 Phosphorylation PhosphoSitePlus
S14 Phosphorylation HPRD   PhosphoSitePlus   UniProt 21406692, 23186163, 18767875, ...19651622, 24275569, 20166139, 19690332, 20068231
R21 Methylation PhosphoSitePlus
S23 Phosphorylation Q16512 (PKN1) , Q13153 (PAK1) neXtProt   phospho.ELM   PhosphoSitePlus   Signor   UniProt 12189148, 24275569
Y26 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 18083107, 23653202, 30639960, ...28076845
S31 Phosphorylation HPRD   PhosphoSitePlus   UniProt 18669648, 23186163, 20068231
K39 Acetylation PhosphoSitePlus
K39 Ubiquitination PhosphoSitePlus
Y50 Phosphorylation PhosphoSitePlus
R90 Methylation PhosphoSitePlus
Y92 Phosphorylation HPRD   PhosphoSitePlus 18083107
T96 Phosphorylation PhosphoSitePlus
K100 Acetylation PhosphoSitePlus
K100 Sumoylation PhosphoSitePlus
K100 Ubiquitination PhosphoSitePlus
K106 Acetylation PhosphoSitePlus
K106 Ubiquitination PhosphoSitePlus
K113 Acetylation PhosphoSitePlus
K113 Ubiquitination PhosphoSitePlus
S118 Phosphorylation Q13153 (PAK1) , Q16512 (PKN1) HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   Signor 20166139, 20058876, 20068231, ...12189148
Y119 Phosphorylation HPRD   PhosphoSitePlus 18083107, 20058876, 20068231
Y133 Phosphorylation HPRD   PhosphoSitePlus 18083107
S134 Phosphorylation PhosphoSitePlus
K138 Acetylation PhosphoSitePlus
K138 Ubiquitination PhosphoSitePlus
T146 Phosphorylation HPRD 20068231
S152 Phosphorylation PhosphoSitePlus
C153 S-Nitrosylation dbSNO 19483679, 25040305
S155 Phosphorylation PhosphoSitePlus
K157 Acetylation PhosphoSitePlus
K157 Ubiquitination PhosphoSitePlus
K176 Ubiquitination PhosphoSitePlus
S189 Phosphorylation PhosphoSitePlus
K195 Ubiquitination PhosphoSitePlus
K225 Ubiquitination PhosphoSitePlus
K228 Ubiquitination PhosphoSitePlus
T238 Phosphorylation PhosphoSitePlus
K241 Methylation PhosphoSitePlus
K241 Ubiquitination PhosphoSitePlus
K251 Acetylation UniProt 22157007
K251 Ubiquitination PhosphoSitePlus
K253 Acetylation UniProt 22157007
K253 Methylation PhosphoSitePlus
K254 Acetylation UniProt 22157007

PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
Y26 H26 Biomuta DOID:9256 / colorectal cancer [ icgc, tcga ]
R90 W90 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ]
Y119 C119 Biomuta DOID:9256 / colorectal cancer [ icgc ]
S189 R189 Biomuta DOID:5041 / esophageal cancer [ icgc ]