Protein Information

Cytoscape View


UniProt AC / UniProt ID P18615 / NELFE_HUMAN
Protein Name Negative elongation factor E
Gene Name Name: NELFE
Synonyms:RD,RDBP;
Organism Homo sapiens (Human)

PRO ID PR:P18615
DAG View
PRO Name negative elongation factor E (human)
Definition A negative elongation factor E that is encoded in the genome of human.
Short Label hNELFE
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P18615 (NELFE) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
Phosphorylation PRO
S9 Phosphorylation PhosphoSitePlus
S36 Phosphorylation PhosphoSitePlus
S37 Phosphorylation PhosphoSitePlus
T41 Phosphorylation PhosphoSitePlus
S42 Phosphorylation PhosphoSitePlus
K47 Sumoylation PhosphoSitePlus
S49 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S51 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
T58 Phosphorylation PhosphoSitePlus
T62 Phosphorylation PhosphoSitePlus
S71 Phosphorylation PhosphoSitePlus
S75 Phosphorylation PhosphoSitePlus
K78 Sumoylation PhosphoSitePlus
S89 Phosphorylation PhosphoSitePlus
T91 Phosphorylation PhosphoSitePlus
K95 Ubiquitination PhosphoSitePlus
T106 Phosphorylation PhosphoSitePlus
S113 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
S115 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 16964243, ...15302935, 18669648, 20068231, 17081983
S123 Phosphorylation PhosphoSitePlus
K130 Ubiquitination PhosphoSitePlus
S131 Phosphorylation Q96GD4 (AURKB) phospho.ELM   PhosphoSitePlus   UniProt 23186163, 18220336, 18669648, ...22267324, 19690332, 20068231
Y133 Phosphorylation PhosphoSitePlus
S135 Phosphorylation PhosphoSitePlus
S139 Phosphorylation PhosphoSitePlus   UniProt 23186163
S140 Phosphorylation phospho.ELM 18669648
R142 Methylation PhosphoSitePlus
S165 Phosphorylation PhosphoSitePlus   UniProt 23186163
Y170 Phosphorylation PhosphoSitePlus
S174 Phosphorylation PhosphoSitePlus
S179 Phosphorylation PhosphoSitePlus   UniProt 24275569
S181 Phosphorylation PhosphoSitePlus   UniProt 21406692
S185 Phosphorylation PhosphoSitePlus   UniProt 21406692
S187 Phosphorylation PhosphoSitePlus
S191 Phosphorylation PhosphoSitePlus
S249 Phosphorylation PhosphoSitePlus   UniProt 23186163
S251 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 21406692
Y265 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
Y267 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
T272 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
T274 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
S281 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 20068231, 18220336
K332 Ubiquitination PhosphoSitePlus
T340 Phosphorylation PhosphoSitePlus
S347 Phosphorylation PhosphoSitePlus
S353 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 23186163, 16964243, 18669648, ...19690332, 20068231
Y367 Phosphorylation PhosphoSitePlus
S368 Phosphorylation PhosphoSitePlus
Y372 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S49 Phosphorylation HPRD 18691976, 20230923, 18452278, ...18669648, 20166139, 20068231
S51 Phosphorylation HPRD 20230923, 18767875, 18452278, ...18669648, 20166139, 20068231
S113 Phosphorylation HPRD 20166139, 18691976, 18669648, ...18452278
S115 Phosphorylation HPRD 19413330, 18691976, 18491316, ...16964243, 18767875, 15302935, 19007248, 18452278, 19651622, 18669648, 18707149, 20166139, 19415658, 20068231, 18212344
S131 Phosphorylation HPRD 19651622, 18669648, 18212344, ...20068231
S140 Phosphorylation HPRD 18669648
S179 Phosphorylation HPRD 19651622, 19664995, 20068231
S181 Phosphorylation HPRD 19651622, 17924679, 20068231, ...18452278
S187 Phosphorylation HPRD 20068231
S191 Phosphorylation HPRD 17081983, 20068231
S251 Phosphorylation HPRD 18669648
Y265 Phosphorylation HPRD 18669648
Y267 Phosphorylation HPRD 18669648
T272 Phosphorylation HPRD 18669648
T274 Phosphorylation HPRD 18669648
S281 Phosphorylation HPRD 18669648, 20068231
S353 Phosphorylation HPRD 19413330, 16964243, 18767875, ...19664994, 19664995, 17322306, 18669648, 19415658, 20068231


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000048580 (hNELFE/PhosRes+) p PRO


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S89 C89 Biomuta DOID:263 / kidney cancer [ tcga ]
S131 Y131 Biomuta DOID:9256 / colorectal cancer [ tcga ] DOID:1909 / melanoma [ cosmic ]
R142 * Biomuta DOID:363 / uterine cancer [ tcga ]
R142 L142 Biomuta DOID:263 / kidney cancer [ tcga ]
S165 N165 Biomuta DOID:363 / uterine cancer [ tcga ]
S251 L251 Biomuta DOID:1909 / melanoma [ icgc, tcga ]
S281 P281 Biomuta DOID:263 / kidney cancer [ cosmic, tcga ]
T340 A340 Biomuta DOID:363 / uterine cancer [ tcga ]
Y372 C372 Biomuta DOID:363 / uterine cancer [ tcga ]