Protein Information

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UniProt AC / UniProt ID P18583 / SON_HUMAN
Protein Name Protein SON
Gene Name Name: SON
Synonyms:C21orf50,DBP5,KIAA1019,NREBP;ORFNames:HSPC310,HSPC312;
Organism Homo sapiens (Human)

PRO ID PR:P18583
DAG View
PRO Name protein SON (human)
Definition A SON protein that is encoded in the genome of human.
Short Label hSON
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P18583 (SON) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
A2 Acetylation UniProt 19413330, 22814378
T3 Phosphorylation PhosphoSitePlus
R10 Methylation PhosphoSitePlus
K16 Acetylation PhosphoSitePlus   UniProt 19608861
K16 Ubiquitination PhosphoSitePlus
T39 Phosphorylation PhosphoSitePlus
S55 Phosphorylation PhosphoSitePlus
K64 Ubiquitination PhosphoSitePlus
K80 Ubiquitination PhosphoSitePlus
K84 Ubiquitination PhosphoSitePlus
C92 S-Nitrosylation dbSNO 26338901
S94 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 23186163, 17081983, 20068231
Y129 Phosphorylation PhosphoSitePlus
K141 Ubiquitination PhosphoSitePlus
S142 Phosphorylation PhosphoSitePlus   UniProt 23186163, 20068231
S152 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 18669648, ...24275569, 19690332, 20068231
S154 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 16565220, ...18669648, 19690332, 20068231
S160 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 18669648
S163 Phosphorylation PhosphoSitePlus
S182 Phosphorylation PhosphoSitePlus
T252 O-Glycosylation PhosphoSitePlus
T253 O-Glycosylation PhosphoSitePlus
K277 Ubiquitination PhosphoSitePlus
S278 Phosphorylation PhosphoSitePlus
S281 Phosphorylation PhosphoSitePlus
T282 Phosphorylation PhosphoSitePlus
S283 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 16964243, 15302935, ...18669648, 24275569, 19690332, 20068231, 17081983
S287 Phosphorylation PhosphoSitePlus
K288 Acetylation PhosphoSitePlus   UniProt 19608861
K288 Ubiquitination PhosphoSitePlus
S348 Phosphorylation PhosphoSitePlus
S354 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
T400 Phosphorylation PhosphoSitePlus   UniProt 24275569
S910 Phosphorylation phospho.ELM   PhosphoSitePlus 15302935
Y921 Phosphorylation PhosphoSitePlus
R922 Methylation PhosphoSitePlus
Y928 Phosphorylation PhosphoSitePlus
R929 Methylation PhosphoSitePlus
Y935 Phosphorylation PhosphoSitePlus
R936 Methylation PhosphoSitePlus
Y942 Phosphorylation PhosphoSitePlus
R943 Methylation PhosphoSitePlus
Y949 Phosphorylation PhosphoSitePlus
R950 Methylation PhosphoSitePlus   UniProt 24129315
Y956 Phosphorylation PhosphoSitePlus
R957 Methylation PhosphoSitePlus
T959 Phosphorylation PhosphoSitePlus   UniProt 23186163
Y963 Phosphorylation PhosphoSitePlus
R964 Methylation PhosphoSitePlus
S966 Phosphorylation PhosphoSitePlus
R968 Methylation PhosphoSitePlus
Y970 Phosphorylation PhosphoSitePlus
R971 Methylation PhosphoSitePlus
R978 Methylation PhosphoSitePlus
R982 Methylation PhosphoSitePlus
R985 Methylation PhosphoSitePlus
R989 Methylation PhosphoSitePlus
R997 Methylation PhosphoSitePlus
S998 Phosphorylation PhosphoSitePlus   UniProt 23186163
R1007 Methylation PhosphoSitePlus
S1012 Phosphorylation PhosphoSitePlus
R1015 Methylation PhosphoSitePlus
S1016 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S1019 Phosphorylation PhosphoSitePlus
Y1020 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
R1022 Methylation PhosphoSitePlus
S1026 Phosphorylation PhosphoSitePlus
R1031 Methylation PhosphoSitePlus
S1035 Phosphorylation PhosphoSitePlus   UniProt 23186163
Y1037 Phosphorylation PhosphoSitePlus
R1039 Methylation PhosphoSitePlus
S1043 Phosphorylation PhosphoSitePlus   UniProt 23186163
Y1045 Phosphorylation PhosphoSitePlus
R1047 Methylation PhosphoSitePlus
S1051 Phosphorylation PhosphoSitePlus
R1056 Methylation PhosphoSitePlus
S1057 Phosphorylation PhosphoSitePlus
S1060 Phosphorylation PhosphoSitePlus   UniProt 23186163
Y1062 Phosphorylation PhosphoSitePlus
R1064 Methylation PhosphoSitePlus
S1068 Phosphorylation PhosphoSitePlus   UniProt 23186163
Y1070 Phosphorylation PhosphoSitePlus
R1072 Methylation PhosphoSitePlus
S1076 Phosphorylation PhosphoSitePlus
R1081 Methylation PhosphoSitePlus
S1082 Phosphorylation PhosphoSitePlus   UniProt 23186163
S1085 Phosphorylation PhosphoSitePlus
R1090 Methylation PhosphoSitePlus
Y1096 Phosphorylation PhosphoSitePlus
S1097 Phosphorylation PhosphoSitePlus
R1101 Methylation PhosphoSitePlus
S1102 Phosphorylation PhosphoSitePlus
Y1107 Phosphorylation PhosphoSitePlus
S1108 Phosphorylation PhosphoSitePlus
R1112 Methylation PhosphoSitePlus
S1117 Phosphorylation PhosphoSitePlus
Y1118 Phosphorylation PhosphoSitePlus
S1216 Phosphorylation Q13535 (ATR) neXtProt 10608806
T1262 Phosphorylation PhosphoSitePlus
T1336 Phosphorylation PhosphoSitePlus
S1480 Phosphorylation PhosphoSitePlus
S1509 Phosphorylation PhosphoSitePlus
T1555 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S1556 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 17081983, 18669648, ...24275569, 19690332
S1570 Phosphorylation PhosphoSitePlus
T1572 Phosphorylation PhosphoSitePlus
K1573 Ubiquitination PhosphoSitePlus
T1576 Phosphorylation PhosphoSitePlus
T1645 Phosphorylation PhosphoSitePlus
S1646 Phosphorylation PhosphoSitePlus
S1648 Phosphorylation PhosphoSitePlus
S1651 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 15302935, 24275569
S1670 Phosphorylation PhosphoSitePlus
K1677 Acetylation PhosphoSitePlus
T1679 Phosphorylation PhosphoSitePlus
K1686 Ubiquitination PhosphoSitePlus
S1688 Phosphorylation PhosphoSitePlus
S1697 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 17081983, ...15302935, 18669648, 24275569, 20068231
S1701 Phosphorylation PhosphoSitePlus   UniProt 23186163
S1702 Phosphorylation PhosphoSitePlus
T1746 Phosphorylation PhosphoSitePlus
S1747 Phosphorylation PhosphoSitePlus   UniProt 23186163
S1759 Phosphorylation PhosphoSitePlus   UniProt 23186163
S1766 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 15302935, 24275569
S1769 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 15302935, ...24275569, 20068231
S1773 Phosphorylation PhosphoSitePlus
S1774 Phosphorylation PhosphoSitePlus
S1780 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S1782 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
S1783 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
S1784 Phosphorylation PhosphoSitePlus
Y1790 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S1820 Phosphorylation PhosphoSitePlus
S1821 Phosphorylation PhosphoSitePlus
S1824 Phosphorylation PhosphoSitePlus
K1827 Acetylation PhosphoSitePlus
S1859 Phosphorylation PhosphoSitePlus
S1885 Phosphorylation PhosphoSitePlus
S1887 Phosphorylation PhosphoSitePlus
S1922 Phosphorylation phospho.ELM   PhosphoSitePlus 17081983
T1924 Phosphorylation phospho.ELM   PhosphoSitePlus 17081983
S1926 Phosphorylation PhosphoSitePlus
S1929 Phosphorylation PhosphoSitePlus
S1931 Phosphorylation PhosphoSitePlus
T1933 Phosphorylation PhosphoSitePlus
S1940 Phosphorylation PhosphoSitePlus
S1942 Phosphorylation PhosphoSitePlus
S1948 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 17081983
S1950 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 17081983
S1952 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
S1954 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648, 17081983
S1957 Phosphorylation PhosphoSitePlus
T1959 Phosphorylation PhosphoSitePlus
S1961 Phosphorylation PhosphoSitePlus
S1964 Phosphorylation PhosphoSitePlus
T1966 Phosphorylation PhosphoSitePlus
S1968 Phosphorylation PhosphoSitePlus
S1971 Phosphorylation PhosphoSitePlus
T1973 Phosphorylation PhosphoSitePlus
S1975 Phosphorylation PhosphoSitePlus
S1978 Phosphorylation PhosphoSitePlus
T1980 Phosphorylation PhosphoSitePlus
S1982 Phosphorylation PhosphoSitePlus
S1985 Phosphorylation PhosphoSitePlus
T1987 Phosphorylation PhosphoSitePlus
S1989 Phosphorylation PhosphoSitePlus
S1992 Phosphorylation PhosphoSitePlus
S1996 Phosphorylation PhosphoSitePlus
S2001 Phosphorylation PhosphoSitePlus
S2003 Phosphorylation PhosphoSitePlus
S2009 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 17081983, ...20068231
S2011 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 17081983, ...18669648, 20068231
S2013 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 17081983, ...15302935, 18669648, 20068231
S2020 Phosphorylation phospho.ELM   PhosphoSitePlus 17081983
T2022 Phosphorylation PhosphoSitePlus
S2029 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 23186163, 17081983
S2031 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 23186163, 17081983
S2046 Phosphorylation PhosphoSitePlus
T2051 Phosphorylation PhosphoSitePlus
K2055 Acetylation PhosphoSitePlus   UniProt 19608861
K2055 Ubiquitination PhosphoSitePlus
K2063 Acetylation PhosphoSitePlus
K2063 Ubiquitination PhosphoSitePlus
K2072 Ubiquitination PhosphoSitePlus
K2096 Ubiquitination PhosphoSitePlus
S2097 Phosphorylation PhosphoSitePlus
T2106 Phosphorylation PhosphoSitePlus
K2108 Ubiquitination PhosphoSitePlus
S2129 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 17287340, 23186163, 17081983
Y2139 Phosphorylation PhosphoSitePlus
K2149 Acetylation PhosphoSitePlus
K2161 Acetylation PhosphoSitePlus
T2163 Phosphorylation PhosphoSitePlus   UniProt 20068231
T2172 Phosphorylation PhosphoSitePlus
K2173 Ubiquitination PhosphoSitePlus
S2179 Phosphorylation PhosphoSitePlus
S2181 Phosphorylation PhosphoSitePlus
K2186 Ubiquitination PhosphoSitePlus
S2190 Phosphorylation PhosphoSitePlus
Y2192 Phosphorylation PhosphoSitePlus
K2200 Ubiquitination PhosphoSitePlus
S2238 Phosphorylation PhosphoSitePlus   UniProt 23186163, 24275569
K2332 Ubiquitination PhosphoSitePlus
K2340 Ubiquitination PhosphoSitePlus
K2344 Ubiquitination PhosphoSitePlus
S2357 Phosphorylation PhosphoSitePlus
K2365 Ubiquitination PhosphoSitePlus
K2370 Ubiquitination PhosphoSitePlus
K2382 Ubiquitination PhosphoSitePlus
K2402 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S152 Phosphorylation phospho.ELM 18669648
S154 Phosphorylation phospho.ELM 18669648
S160 Phosphorylation phospho.ELM 18669648
S283 Phosphorylation phospho.ELM 18669648
S354 Phosphorylation phospho.ELM 18669648
Y963 Phosphorylation PhosphoSitePlus
S1016 Phosphorylation phospho.ELM 18669648
Y1020 Phosphorylation phospho.ELM 18669648
T1555 Phosphorylation phospho.ELM 18669648
S1556 Phosphorylation phospho.ELM 18669648
T1572 Phosphorylation PhosphoSitePlus
T1576 Phosphorylation PhosphoSitePlus
S1697 Phosphorylation phospho.ELM 18669648
S1780 Phosphorylation phospho.ELM 18669648
S1782 Phosphorylation phospho.ELM 18669648
S1783 Phosphorylation phospho.ELM 18669648
Y1790 Phosphorylation phospho.ELM 18669648
K1827 Acetylation PhosphoSitePlus
S1948 Phosphorylation phospho.ELM 18669648
S1950 Phosphorylation phospho.ELM 18669648
S1952 Phosphorylation phospho.ELM 18669648
S1954 Phosphorylation phospho.ELM 18669648
S2003 Phosphorylation PhosphoSitePlus
S2009 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S2011 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S2013 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S2218 Phosphorylation PhosphoSitePlus
R2221 Methylation PhosphoSitePlus
S2247 Phosphorylation PhosphoSitePlus
K2252 Ubiquitination PhosphoSitePlus
Y2285 Phosphorylation PhosphoSitePlus
R2291 Methylation PhosphoSitePlus
R2295 Methylation PhosphoSitePlus
Y2297 Phosphorylation PhosphoSitePlus
S2299 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S152 Phosphorylation phospho.ELM 18669648
S154 Phosphorylation phospho.ELM 18669648
S160 Phosphorylation phospho.ELM 18669648
S283 Phosphorylation phospho.ELM 18669648
S354 Phosphorylation phospho.ELM 18669648
Y963 Phosphorylation PhosphoSitePlus
S1016 Phosphorylation phospho.ELM 18669648
Y1020 Phosphorylation phospho.ELM 18669648
T1555 Phosphorylation phospho.ELM 18669648
S1556 Phosphorylation phospho.ELM 18669648
T1572 Phosphorylation PhosphoSitePlus
T1576 Phosphorylation PhosphoSitePlus
S1697 Phosphorylation phospho.ELM 18669648
S1780 Phosphorylation phospho.ELM 18669648
S1782 Phosphorylation phospho.ELM 18669648
S1783 Phosphorylation phospho.ELM 18669648
Y1790 Phosphorylation phospho.ELM 18669648
K1827 Acetylation PhosphoSitePlus
S1948 Phosphorylation phospho.ELM 18669648
S1950 Phosphorylation phospho.ELM 18669648
S1952 Phosphorylation phospho.ELM 18669648
S1954 Phosphorylation phospho.ELM 18669648
S2003 Phosphorylation PhosphoSitePlus
S2009 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S2011 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S2013 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S2421 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S154 Y154 Biomuta DOID:3571 / liver cancer [ icgc ]
S283 T283 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc, tcga ]
S348 L348 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ]
R922 M922 Biomuta DOID:1324 / lung cancer [ cosmic ]
R936 I936 Biomuta DOID:5041 / esophageal cancer [ icgc ]
R950 I950 Biomuta DOID:9256 / colorectal cancer [ icgc ]
T959 I959 Biomuta DOID:9256 / colorectal cancer [ tcga ] DOID:1909 / melanoma [ cosmic ]
R964 M964 Biomuta DOID:363 / uterine cancer [ tcga ]
Y970 * Biomuta DOID:3070 / malignant glioma [ tcga ]
R971 K971 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc, tcga ]
R997 H997 Biomuta DOID:0060119 / pharynx cancer [ cosmic ] DOID:10534 / stomach cancer [ cosmic ]
R1007 C1007 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc, tcga ]
R1015 C1015 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ]
R1015 H1015 Biomuta DOID:9256 / colorectal cancer [ icgc ]
R1072 L1072 Biomuta DOID:3571 / liver cancer [ icgc ]
R1081 Q1081 Biomuta DOID:363 / uterine cancer [ tcga ]
R1090 W1090 Biomuta DOID:1909 / melanoma [ cosmic ]
S1108 C1108 Biomuta DOID:1324 / lung cancer [ cosmic ]
S1108 F1108 Biomuta DOID:1793 / pancreatic cancer [ icgc ] DOID:10283 / prostate cancer [ cosmic ]
Y1118 F1118 Biomuta DOID:11054 / urinary bladder cancer [ tcga ]
T1555 S1555 Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
K1677 E1677 Biomuta DOID:363 / uterine cancer [ tcga ]
S1782 F1782 Biomuta DOID:2394 / ovarian cancer [ icgc, tcga ] DOID:2994 / germ cell cancer [ cosmic ]
S1820 C1820 Biomuta DOID:1324 / lung cancer [ tcga ]
S1929 I1929 Biomuta DOID:3571 / liver cancer [ icgc ]
S1952 F1952 Biomuta DOID:3963 / thyroid carcinoma [ cosmic, icgc ]
S1992 N1992 Biomuta DOID:11934 / head and neck cancer [ tcga ]
S2003 F2003 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc, tcga ]
S2031 P2031 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc, tcga ]
S2046 L2046 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
K2096 T2096 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ]
S2129 L2129 Biomuta DOID:10534 / stomach cancer [ tcga ]
K2149 T2149 Biomuta DOID:11054 / urinary bladder cancer [ tcga ]
K2149 Q2149 Biomuta DOID:1793 / pancreatic cancer [ icgc, tcga ] DOID:10283 / prostate cancer [ cosmic ]
K2344 I2344 Biomuta DOID:5041 / esophageal cancer [ icgc ]