iPTMnet Report for P18440 (NAT1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P18440 / ARY1_HUMAN
Protein Name Arylamine N-acetyltransferase 1
Gene Name Name: NAT1
Synonyms:AAC1;
Organism Homo sapiens (Human)

PRO ID PR:P18440
DAG View
PRO Name arylamine N-acetyltransferase 1 (human)
Definition An arylamine N-acetyltransferase 1 that is encoded in the genome of human.
Short Label hNAT1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P18440 (NAT1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
M1 Acetylation UniProt 22814378
K18 Ubiquitination PhosphoSitePlus
T25 Phosphorylation HPRD   PhosphoSitePlus 18452278
K100 Acetylation PhosphoSitePlus
Y101 Phosphorylation PhosphoSitePlus
K185 Ubiquitination PhosphoSitePlus
K188 Acetylation PhosphoSitePlus
K188 Ubiquitination PhosphoSitePlus
S191 Phosphorylation PhosphoSitePlus
Y208 Phosphorylation PhosphoSitePlus
S214 Phosphorylation PhosphoSitePlus
S221 Phosphorylation PhosphoSitePlus
T227 Phosphorylation PhosphoSitePlus
C233 Methylation IEDB 31844290
K247 Ubiquitination PhosphoSitePlus
K256 Ubiquitination PhosphoSitePlus
S259 Phosphorylation PhosphoSitePlus
K265 Ubiquitination PhosphoSitePlus
S274 Phosphorylation PhosphoSitePlus
T289 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
M1 L1 Biomuta DOID:1612 / breast cancer [ icgc ]
S191 C191 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
Y208 C208 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S214 A214 Biomuta [ cosmic ]
S221 L221 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
T227 I227 Biomuta DOID:4159 / skin cancer [ cosmic ]
K247 R247 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S274 F274 Biomuta DOID:4159 / skin cancer [ cosmic ]
T289 A289 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]