iPTMnet Report for P18433 (PTPRA)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P18433 / PTPRA_HUMAN
Protein Name Receptor-type tyrosine-protein phosphatase alpha precursor
Gene Name Name: PTPRA
Synonyms:PTPA,PTPRL2;
Organism Homo sapiens (Human)

PRO ID PR:P18433
DAG View
PRO Name receptor-type tyrosine-protein phosphatase alpha (human)
Definition A receptor-type tyrosine-protein phosphatase alpha that is encoded in the genome of human.
Short Label hPTPRA
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P18433 (PTPRA) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S18 Phosphorylation PhosphoSitePlus
N36 N-Glycosylation GlyGen 24190977
S187 Phosphorylation phospho.ELM 17081983
S189 Phosphorylation Q05655 (PRKCD) phospho.ELM   PhosphoSitePlus   Signor 11923305, 17081983, 11676480
S204 Phosphorylation Q9UQM7 (CAMK2A) , Q05655 (PRKCD) neXtProt   RLIMS-P 20385765, 18809727, 12826681
S211 O-Glycosylation GlyGen 29351928
S211 Phosphorylation PhosphoSitePlus
S213 Phosphorylation Q05655 (PRKCD) phospho.ELM   PhosphoSitePlus   Signor 11923305, 11676480
T214 Phosphorylation PhosphoSitePlus
Y218 Phosphorylation PhosphoSitePlus
K225 Ubiquitination PhosphoSitePlus
Y271 Phosphorylation PhosphoSitePlus
S293 Phosphorylation PhosphoSitePlus
K307 Ubiquitination PhosphoSitePlus
S407 Phosphorylation PhosphoSitePlus
Y522 Phosphorylation PhosphoSitePlus
K524 Ubiquitination PhosphoSitePlus
S542 Phosphorylation PhosphoSitePlus
T552 Phosphorylation PhosphoSitePlus
K560 Ubiquitination PhosphoSitePlus
Y588 Phosphorylation phospho.ELM   PhosphoSitePlus 7518772
K765 Acetylation PhosphoSitePlus
S766 Phosphorylation PhosphoSitePlus
Y791 Phosphorylation PhosphoSitePlus
S796 Phosphorylation PhosphoSitePlus
Y798 Phosphorylation P12931 (SRC) IntAct   phospho.ELM   PhosphoSitePlus   Signor   UniProt 22801373, 23186163, 17507376, ...18083107, 24275569, 10698938, 7518772, 11923305, 19690332, 20068231
Site PTM Type PTM Enzyme Score Source PMID
S187 Phosphorylation HPRD 17081983
S189 Phosphorylation Q05655 (PRKCD) HPRD 19651622, 11923305, 11676480
S213 Phosphorylation Q05655 (PRKCD) HPRD 11923305, 11676480
Y271 Phosphorylation HPRD 18578522
Y791 Phosphorylation HPRD 17016520, 16497976
Y798 Phosphorylation P12931 (SRC) HPRD 17016520, 18578522, 17389395, ...7518772, 11923305, 20068231, 16497976
Site PTM Type PTM Enzyme Score Source PMID
S178 Phosphorylation HPRD 17081983
S180 Phosphorylation Q05655 (PRKCD) HPRD 19651622, 11923305, 11676480
S204 Phosphorylation Q05655 (PRKCD) HPRD 11923305, 11676480
Y262 Phosphorylation HPRD 18578522
Y782 Phosphorylation HPRD 17016520, 16497976
Y789 Phosphorylation P12931 (SRC) HPRD 17016520, 18578522, 17389395, ...7518772, 11923305, 20068231, 16497976


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation P18433 (PTPRA) S204 P12931 (SRC) unknown eFIP 20385765


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S204 R204 Biomuta [ cosmic ] DOID:1612 / breast cancer [ icgc ]
S213 R213 Biomuta [ cosmic ] DOID:1612 / breast cancer [ icgc ]
T214 I214 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]
Y218 D218 Biomuta DOID:4606 / bile duct cancer [ cosmic ]
Y262 C262 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
Y271 C271 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
Y522 * Biomuta DOID:3571 / liver cancer [ cosmic ]
Y588 F588 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]