iPTMnet Report for P18206 (VCL)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P18206 / VINC_HUMAN
Protein Name Vinculin
Gene Name Name: VCL
Organism Homo sapiens (Human)

PRO ID PR:P18206
DAG View
PRO Name vinculin (human)
Definition A vinculin that is encoded in the genome of human.
Short Label hVCL
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P18206 (VCL) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
T8 Phosphorylation PhosphoSitePlus
S52 Phosphorylation PhosphoSitePlus
K59 Ubiquitination PhosphoSitePlus
K71 Acetylation PhosphoSitePlus
K71 Ubiquitination PhosphoSitePlus
C85 S-Nitrosylation dbSNO 16648260, 22178444
S97 Phosphorylation PhosphoSitePlus
Y100 Phosphorylation PhosphoSitePlus   RLIMS-P 30022044
S101 Phosphorylation PhosphoSitePlus
Y107 Phosphorylation PhosphoSitePlus
S112 Phosphorylation PhosphoSitePlus
K173 Acetylation PhosphoSitePlus   UniProt 19608861
S207 Phosphorylation PhosphoSitePlus
K216 Ubiquitination PhosphoSitePlus
K219 Ubiquitination PhosphoSitePlus
K228 Ubiquitination PhosphoSitePlus
S252 Phosphorylation PhosphoSitePlus
S260 Phosphorylation PhosphoSitePlus   UniProt 24275569
K267 Acetylation PhosphoSitePlus
S272 Phosphorylation PhosphoSitePlus
S275 Phosphorylation PhosphoSitePlus   UniProt 24275569
K276 Acetylation PhosphoSitePlus
S288 Phosphorylation PhosphoSitePlus   UniProt 23186163, 20068231, 24275569
S290 Phosphorylation PhosphoSitePlus   UniProt 20068231, 18669648, 21406692, ...24275569
K308 Ubiquitination PhosphoSitePlus
K316 Ubiquitination PhosphoSitePlus
T324 Phosphorylation PhosphoSitePlus
S345 Phosphorylation PhosphoSitePlus
S346 Phosphorylation PhosphoSitePlus   UniProt 21406692, 24275569
S357 Phosphorylation PhosphoSitePlus
K366 Ubiquitination PhosphoSitePlus
K373 Acetylation PhosphoSitePlus
T378 Phosphorylation PhosphoSitePlus
S380 Phosphorylation PhosphoSitePlus
S383 Phosphorylation PhosphoSitePlus
K386 Ubiquitination PhosphoSitePlus
K387 Ubiquitination PhosphoSitePlus
R409 Methylation PhosphoSitePlus
K426 Ubiquitination PhosphoSitePlus
S434 Phosphorylation PhosphoSitePlus   UniProt 21406692
S439 Phosphorylation PhosphoSitePlus
T442 Phosphorylation PhosphoSitePlus
S443 Phosphorylation PhosphoSitePlus
K444 Acetylation PhosphoSitePlus
K444 Ubiquitination PhosphoSitePlus
K464 Ubiquitination PhosphoSitePlus
K476 Ubiquitination PhosphoSitePlus
K496 Acetylation PhosphoSitePlus   UniProt 19608861
T508 Phosphorylation phospho.ELM   PhosphoSitePlus 16097034
R512 Methylation PhosphoSitePlus
Y537 Phosphorylation PhosphoSitePlus
K544 Ubiquitination PhosphoSitePlus
C545 S-Nitrosylation dbSNO 25040305
S566 Phosphorylation PhosphoSitePlus
S574 Phosphorylation PhosphoSitePlus
S579 Phosphorylation PhosphoSitePlus   UniProt 24275569
K581 Ubiquitination PhosphoSitePlus
K584 Ubiquitination PhosphoSitePlus
S596 Phosphorylation PhosphoSitePlus
S600 Phosphorylation PhosphoSitePlus   UniProt 24275569
T604 Phosphorylation PhosphoSitePlus   UniProt 24275569
T614 Phosphorylation PhosphoSitePlus
R622 Methylation PhosphoSitePlus
S637 Phosphorylation PhosphoSitePlus
K639 Acetylation PhosphoSitePlus
K639 Ubiquitination PhosphoSitePlus
T643 Phosphorylation PhosphoSitePlus
K655 Ubiquitination PhosphoSitePlus
T657 Phosphorylation PhosphoSitePlus
S664 Phosphorylation PhosphoSitePlus
K666 Ubiquitination PhosphoSitePlus
T672 Phosphorylation PhosphoSitePlus   UniProt 23186163
S677 Phosphorylation PhosphoSitePlus
Y692 Phosphorylation phospho.ELM   PhosphoSitePlus 18083107
T697 Phosphorylation PhosphoSitePlus
K699 Acetylation PhosphoSitePlus
K699 Ubiquitination PhosphoSitePlus
K708 Ubiquitination PhosphoSitePlus
T719 Phosphorylation PhosphoSitePlus
K720 Ubiquitination PhosphoSitePlus
S721 Phosphorylation PhosphoSitePlus   UniProt 21406692, 23186163, 17081983, ...18669648, 24275569, 20068231
S726 Phosphorylation PhosphoSitePlus
K731 Ubiquitination PhosphoSitePlus
T754 Phosphorylation PhosphoSitePlus
S755 Phosphorylation PhosphoSitePlus
K768 Acetylation PhosphoSitePlus
K768 Ubiquitination PhosphoSitePlus
K778 Acetylation PhosphoSitePlus
K778 Ubiquitination PhosphoSitePlus
K784 Ubiquitination PhosphoSitePlus
S787 Phosphorylation PhosphoSitePlus
K792 Ubiquitination PhosphoSitePlus
S795 Phosphorylation PhosphoSitePlus   UniProt 24275569
K802 Ubiquitination PhosphoSitePlus
S809 Phosphorylation PhosphoSitePlus   UniProt 24275569
K815 Ubiquitination PhosphoSitePlus
S816 Phosphorylation PhosphoSitePlus
S820 Phosphorylation PhosphoSitePlus
Y822 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 18083107, 18669648, 29487179, ...24751539
K862 Ubiquitination PhosphoSitePlus
S972 Phosphorylation PhosphoSitePlus
S981 Phosphorylation PhosphoSitePlus
S982 Phosphorylation PhosphoSitePlus
K983 Ubiquitination PhosphoSitePlus
K992 Acetylation PhosphoSitePlus
R993 Methylation PhosphoSitePlus
S1002 Phosphorylation PhosphoSitePlus
R1003 Methylation PhosphoSitePlus
K1020 Ubiquitination PhosphoSitePlus
C1053 S-Nitrosylation dbSNO 25040305, 2212679, 22126794
K1064 Ubiquitination PhosphoSitePlus
K1070 Acetylation PhosphoSitePlus
K1070 Ubiquitination PhosphoSitePlus
S1080 Phosphorylation PhosphoSitePlus
S1101 Phosphorylation phospho.ELM 11741957
S1113 Phosphorylation phospho.ELM 11741957
T1123 Phosphorylation PhosphoSitePlus
T1130 Phosphorylation PhosphoSitePlus
Y1133 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 15229287
Site PTM Type PTM Enzyme Score Source PMID
Y100 Phosphorylation HPRD 15229287
Y100 Phosphorylation P12931 (SRC) HPRD 15229287
S288 Phosphorylation HPRD 19651622, 20166139, 19664994, ...17081983, 20068231
S290 Phosphorylation HPRD 17081983, 20058876, 19664994, ...19664995, 19651622, 18510355, 18669648, 20166139, 19415658, 20068231
S346 Phosphorylation HPRD 20166139, 20068231
S380 Phosphorylation HPRD 20068231
S434 Phosphorylation HPRD 19664994
T442 Phosphorylation HPRD 20068231
S443 Phosphorylation HPRD 20068231
S579 Phosphorylation HPRD 20166139, 19664994
T604 Phosphorylation HPRD 19415658, 19664995, 17081983
Y692 Phosphorylation HPRD 18083107
S721 Phosphorylation HPRD 18578522, 17081983, 19664994, ...19651622, 18669648, 20166139, 20068231, 18212344
S809 Phosphorylation HPRD 19664994
Y822 Phosphorylation HPRD 17016520, 17389395, 19664994, ...18083107, 18669648, 20068231
S1101 Phosphorylation HPRD 11741957
S1101 Phosphorylation P17252 (PRKCA) HPRD 11741957
S1113 Phosphorylation HPRD 11741957
S1113 Phosphorylation P17252 (PRKCA) HPRD 11741957
T1123 Phosphorylation HPRD 19664994
Y1133 Phosphorylation HPRD 15229287
Y1133 Phosphorylation P12931 (SRC) HPRD 15229287
Site PTM Type PTM Enzyme Score Source PMID
K71 Acetylation PhosphoSitePlus
Y100 Phosphorylation HPRD   PhosphoSitePlus 15229287
Y100 Phosphorylation P12931 (SRC) HPRD 15229287
S288 Phosphorylation HPRD 19651622, 20166139, 19664994, ...17081983, 20068231
S290 Phosphorylation HPRD 17081983, 20058876, 19664994, ...19664995, 19651622, 18510355, 18669648, 20166139, 19415658, 20068231
S346 Phosphorylation HPRD 20166139, 20068231
S380 Phosphorylation HPRD 20068231
S434 Phosphorylation HPRD 19664994
T442 Phosphorylation HPRD 20068231
S443 Phosphorylation HPRD 20068231
T508 Phosphorylation PhosphoSitePlus
S579 Phosphorylation HPRD 20166139, 19664994
T604 Phosphorylation HPRD 19415658, 19664995, 17081983
Y692 Phosphorylation HPRD   PhosphoSitePlus 18083107
S721 Phosphorylation HPRD 18578522, 17081983, 19664994, ...19651622, 18669648, 20166139, 20068231, 18212344
K768 Acetylation PhosphoSitePlus
S809 Phosphorylation HPRD 19664994
Y822 Phosphorylation HPRD   PhosphoSitePlus 17016520, 17389395, 19664994, ...18083107, 18669648, 20068231
K924 Acetylation PhosphoSitePlus
K1002 Acetylation PhosphoSitePlus
S1033 Phosphorylation HPRD 11741957
S1033 Phosphorylation P17252 (PRKCA) HPRD 11741957
S1045 Phosphorylation HPRD 11741957
S1045 Phosphorylation P17252 (PRKCA) HPRD 11741957
T1055 Phosphorylation HPRD 19664994
Y1065 Phosphorylation HPRD   PhosphoSitePlus 15229287
Y1065 Phosphorylation P12931 (SRC) HPRD 15229287


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S52 R52 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
S97 P97 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S101 * Biomuta DOID:1324 / lung cancer [ cosmic ]
S101 L101 Biomuta DOID:4159 / skin cancer [ cosmic ]
K173 N173 Biomuta DOID:1319 / brain cancer [ cosmic, icgc ]
S207 * Biomuta DOID:1612 / breast cancer [ cosmic ]
K219 E219 Biomuta DOID:1324 / lung cancer [ cosmic ]
K228 N228 Biomuta DOID:9256 / colorectal cancer [ icgc ]
K276 E276 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S346 P346 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
K386 N386 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
R409 * Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S439 Y439 Biomuta DOID:4159 / skin cancer [ cosmic ]
K464 E464 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K476 E476 Biomuta DOID:1793 / pancreatic cancer [ cosmic, icgc ]
R512 S512 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
K581 T581 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
R622 K622 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
Y692 H692 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K699 * Biomuta DOID:1781 / thyroid gland cancer [ cosmic ]
K778 R778 Biomuta DOID:3565 / meningioma [ cosmic ]
S795 F795 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S809 F809 Biomuta DOID:1793 / pancreatic cancer [ cosmic ]
Y822 C822 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
R993 H993 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:4362 / cervical cancer [ icgc ] DOID:1324 / lung cancer [ cosmic, icgc ]
Y1065 H1065 Biomuta DOID:9256 / colorectal cancer [ cosmic ] DOID:10283 / prostate cancer [ cosmic ] DOID:10534 / stomach cancer [ cosmic, icgc ] DOID:363 / uterine cancer [ cosmic, icgc ] DOID:1793 / pancreatic cancer [ cosmic ]
S1080 T1080 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]
Y1133 H1133 Biomuta DOID:10283 / prostate cancer [ cosmic ]