iPTMnet Report for P17980 (PSMC3)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P17980 / PRS6A_HUMAN
Protein Name 26S proteasome regulatory subunit 6A
Gene Name Name: PSMC3
Synonyms:TBP1;
Organism Homo sapiens (Human)

PRO ID PR:P17980
DAG View
PRO Name 26S proteasome regulatory subunit 6A (human)
Definition A 26S proteasome regulatory subunit 6A that is encoded in the genome of human.
Short Label hPSMC3
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P17980 (PSMC3) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
M1 Acetylation UniProt 19413330, 21406692, 22814378, ...20068231
S9 Phosphorylation HPRD   PhosphoSitePlus   UniProt 19413330, 21406692, 23186163, ...17323924, 20068231
K16 Ubiquitination PhosphoSitePlus
K35 Ubiquitination PhosphoSitePlus
T38 Phosphorylation PhosphoSitePlus
S50 Phosphorylation PhosphoSitePlus
K53 Ubiquitination PhosphoSitePlus
K56 Ubiquitination PhosphoSitePlus
R61 Methylation PhosphoSitePlus
K70 Ubiquitination PhosphoSitePlus
K79 Ubiquitination PhosphoSitePlus
K84 Ubiquitination PhosphoSitePlus
K118 Ubiquitination PhosphoSitePlus
K125 Ubiquitination PhosphoSitePlus
T131 Phosphorylation PhosphoSitePlus
Y132 Phosphorylation PhosphoSitePlus
K144 Ubiquitination PhosphoSitePlus
K146 Ubiquitination PhosphoSitePlus
K155 Ubiquitination PhosphoSitePlus
T163 Phosphorylation PhosphoSitePlus
K173 Ubiquitination PhosphoSitePlus
T182 Phosphorylation PhosphoSitePlus
Y185 Phosphorylation PhosphoSitePlus
S186 Phosphorylation PhosphoSitePlus
K193 Ubiquitination PhosphoSitePlus
K209 Ubiquitination PhosphoSitePlus
K211 Acetylation PhosphoSitePlus
K211 Ubiquitination PhosphoSitePlus
K221 Ubiquitination PhosphoSitePlus
K233 Ubiquitination PhosphoSitePlus
C240 Methylation IEDB 31844290
K245 Ubiquitination PhosphoSitePlus
K250 Ubiquitination PhosphoSitePlus
K266 Ubiquitination PhosphoSitePlus
K276 Ubiquitination PhosphoSitePlus
K278 Ubiquitination PhosphoSitePlus
K294 Ubiquitination PhosphoSitePlus
S298 Phosphorylation PhosphoSitePlus
K300 Acetylation PhosphoSitePlus
K300 Ubiquitination PhosphoSitePlus
K327 Ubiquitination PhosphoSitePlus
S345 Phosphorylation PhosphoSitePlus
K351 Ubiquitination PhosphoSitePlus
K372 Acetylation PhosphoSitePlus
K372 Ubiquitination PhosphoSitePlus
S376 Phosphorylation PhosphoSitePlus   UniProt 23186163
Y381 Phosphorylation PhosphoSitePlus   RLIMS-P 28435470
C387 S-Nitrosylation dbSNO 26338901
K397 Ubiquitination PhosphoSitePlus
Y420 Phosphorylation PhosphoSitePlus
K432 Ubiquitination PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T38 S38 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
S50 N50 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
K84 N84 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]
K125 N125 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
T131 A131 Biomuta DOID:363 / uterine cancer [ icgc ]
T131 M131 Biomuta DOID:263 / kidney cancer [ cosmic ]
Y132 C132 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
T163 M163 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
T182 M182 Biomuta DOID:363 / uterine cancer [ cosmic ]
K233 N233 Biomuta DOID:1324 / lung cancer [ cosmic ] DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
S345 L345 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
C387 Y387 Biomuta DOID:4159 / skin cancer [ cosmic ]
K397 Q397 Biomuta DOID:1324 / lung cancer [ cosmic ]