iPTMnet Report P17948 FLT1

Protein Information

UniProt AC / UniProt ID	P17948 / VGFR1_HUMAN
Protein Name	Vascular endothelial growth factor receptor 1 precursor
Gene Name	Name: FLT1 Synonyms:FLT,FRT,VEGFR1;
Organism	Homo sapiens (Human)

PRO ID	PR:P17948 DAG View
PRO Name	vascular endothelial growth factor receptor 1 (human)
Definition	A vascular endothelial growth factor receptor 1 that is encoded in the genome of human.
Short Label	hFLT1
Category	organism-gene

Interactive Sequence View

	Select/align proteoforms across species

P17948 (FLT1) as Substrate

Expanded View

Site	PTM Type	PTM Enzyme	Score	Source	PMID
N164	N-Glycosylation		score1	GlyGen	29741879
N196	N-Glycosylation		score1	GlyGen	23345538
T218	Phosphorylation		score1	PhosphoSitePlus
T222	Phosphorylation		score1	PhosphoSitePlus
N251	N-Glycosylation		score1	GlyGen	29741879
T255	Phosphorylation		score1	PhosphoSitePlus
T265	Phosphorylation		score1	PhosphoSitePlus
S267	Phosphorylation		score1	PhosphoSitePlus
K306	Methylation		score1	PhosphoSitePlus
N323	N-Glycosylation		score1	GlyGen	29741879, 23345538
Y383	Phosphorylation		score1	PhosphoSitePlus
Y388	Phosphorylation		score1	PhosphoSitePlus
T404	Phosphorylation		score1	PhosphoSitePlus
K410	Ubiquitination		score1	PhosphoSitePlus
N474	N-Glycosylation		score1	GlyGen	23345538
T588	Phosphorylation		score1	PhosphoSitePlus
T599	Phosphorylation		score1	PhosphoSitePlus
T618	Phosphorylation		score1	PhosphoSitePlus
N625	N-Glycosylation		score1	GlyGen	23345538
S631	Phosphorylation		score1	PhosphoSitePlus
T633	Phosphorylation		score1	PhosphoSitePlus
S739	Phosphorylation		score1	PhosphoSitePlus
S742	Phosphorylation		score1	PhosphoSitePlus
S743	Phosphorylation		score1	PhosphoSitePlus
Y745	Phosphorylation		score1	PhosphoSitePlus
T747	Phosphorylation		score1	PhosphoSitePlus
T751	Phosphorylation		score1	PhosphoSitePlus
Y794	Phosphorylation	P17948 (FLT1)	score4	neXtProt phospho.ELM PhosphoSitePlus	16946136, 11741094, 9398617
Y815	Phosphorylation		score1	PhosphoSitePlus
K831	Methylation		score1	PhosphoSitePlus
Y911	Phosphorylation		score1	PhosphoSitePlus
Y914	Phosphorylation	P17948 (FLT1)	score3	neXtProt UniProt	9722576
Y920	Phosphorylation		score1	PhosphoSitePlus
K932	Methylation		score1	PhosphoSitePlus
Y1048	Phosphorylation		score4	phospho.ELM PhosphoSitePlus RLIMS-P	18083107, 25880726
Y1053	Phosphorylation		score2	phospho.ELM PhosphoSitePlus	18083107
K1064	Ubiquitination		score1	PhosphoSitePlus
K1153	Methylation		score1	PhosphoSitePlus
Y1169	Phosphorylation	P17948 (FLT1)	score4	neXtProt phospho.ELM PhosphoSitePlus Signor UniProt	9299537, 11513746
S1197	Phosphorylation		score1	PhosphoSitePlus
S1199	Phosphorylation		score1	PhosphoSitePlus
K1202	Ubiquitination		score1	PhosphoSitePlus
S1205	Phosphorylation		score1	PhosphoSitePlus
S1207	Phosphorylation		score1	PhosphoSitePlus
Y1213	Phosphorylation	P17948 (FLT1)	score4	neXtProt phospho.ELM PhosphoSitePlus RLIMS-P Signor UniProt	9299537, 11583921, 9722576, ...9600074, 12796773, 27009237, 11513746, 28797294, 23383198
Y1242	Phosphorylation	P17948 (FLT1)	score4	neXtProt phospho.ELM PhosphoSitePlus Signor UniProt	9722576, 11513746
Y1309	Phosphorylation	P17948 (FLT1)	score3	neXtProt UniProt	12796773
Y1327	Phosphorylation	P17948 (FLT1)	score4	neXtProt phospho.ELM PhosphoSitePlus Signor UniProt	9722576, 12796773, 11513746
Y1333	Phosphorylation	P17948 (FLT1)	score4	neXtProt phospho.ELM PhosphoSitePlus RLIMS-P Signor UniProt	29193887, 9722576, 9600074, ...23059825, 11513746

Site	PTM Type	PTM Enzyme	Score	Source	PMID
N196	N-Glycosylation		score1	PRO	23345538
N323	N-Glycosylation		score1	PRO	23345538
N474	N-Glycosylation		score1	PRO	23345538
N625	N-Glycosylation		score1	PRO	23345538
Y794	Phosphorylation		score2	HPRD	11741094, 9398617
Y1048	Phosphorylation		score0	HPRD	18083107
Y1053	Phosphorylation		score0	HPRD	18083107
Y1169	Phosphorylation		score2	HPRD	9299537, 11513746
Y1213	Phosphorylation	P17948 (FLT1)	score1	HPRD	11513746
Y1242	Phosphorylation	P17948 (FLT1)	score1	HPRD	11513746
Y1327	Phosphorylation	P17948 (FLT1)	score1	HPRD	11513746
Y1333	Phosphorylation	P17948 (FLT1)	score1	HPRD	11513746

	Site	PTM Type	PTM Enzyme	Score	Source	PMID
	T681	Phosphorylation		score1	PhosphoSitePlus
	S683	Phosphorylation		score1	PhosphoSitePlus

	Site	PTM Type	PTM Enzyme	Score	Source	PMID
	S9	Phosphorylation		score1	PhosphoSitePlus

P17948 (FLT1) as PTM Enzyme

Protein as Phosphorylation Enzyme

Substrate	Site	Score	Source	PMID
P17948 (FLT1)	Y794	score2	neXtProt	16946136
P17948 (FLT1)	Y914	score3	neXtProt UniProt	9722576
P17948 (FLT1)	Y1169	score3	neXtProt PhosphoSitePlus Signor UniProt	9299537
P17948 (FLT1)	Y1213	score4	HPRD neXtProt phospho.ELM PhosphoSitePlus Signor UniProt	9722576, 11583921, 11513746, ...9299537
P17948-1 (FLT1)	Y1242	score4	HPRD neXtProt phospho.ELM PhosphoSitePlus Signor UniProt	9722576, 11513746
P17948 (FLT1)	Y1309	score3	neXtProt UniProt	12796773
P17948 (FLT1)	Y1327	score4	HPRD neXtProt phospho.ELM PhosphoSitePlus Signor UniProt	9722576, 12796773, 11513746
P17948 (FLT1)	Y1333	score4	HPRD neXtProt phospho.ELM PhosphoSitePlus Signor UniProt	9722576, 11513746

PTM sites affected in variants

Site	Variant	Source	Disease [Sample source]
N164	I164	Biomuta	DOID:363 / uterine cancer [ cosmic ]
N164	K164	Biomuta	DOID:1324 / lung cancer [ cosmic ]
N251	S251	Biomuta	DOID:2394 / ovarian cancer [ cosmic ]
T255	N255	Biomuta	DOID:1793 / pancreatic cancer [ cosmic ]
S267	N267	Biomuta	DOID:4159 / skin cancer [ cosmic ]
N323	K323	Biomuta	DOID:9256 / colorectal cancer [ cosmic ]
Y383	H383	Biomuta	DOID:263 / kidney cancer [ cosmic, icgc ]
N474	K474	Biomuta	DOID:9256 / colorectal cancer [ cosmic ]
T599	A599	Biomuta	DOID:9256 / colorectal cancer [ cosmic ]
T599	R599	Biomuta	DOID:3571 / liver cancer [ cosmic, icgc ]
S631	L631	Biomuta	DOID:1324 / lung cancer [ cosmic, icgc ]
Y745	C745	Biomuta	DOID:1324 / lung cancer [ cosmic ]
T747	A747	Biomuta	DOID:1324 / lung cancer [ cosmic ]
T751	P751	Biomuta	DOID:9256 / colorectal cancer [ cosmic ]
Y815	C815	Biomuta	DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]
S1199	*	Biomuta	DOID:1612 / breast cancer [ cosmic ]
Y1309	H1309	Biomuta	[ cosmic ] DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]
Y1327	N1327	Biomuta	DOID:3571 / liver cancer [ cosmic ]

PTM Type		Select All, None
Acetylation	N-Glycosylation	O-Glycosylation
C-Glycosylation	S-Glycosylation	Methylation
Myristoylation	Phosphorylation	Sumoylation
Ubiquitination	S-Nitrosylation

Select organisms		Select All, None
Human	Mouse	Rat
Cow	Chicken	Zebrafish
Fruit fly	C. elegans	Baker's yeast
Fission yeast	A. thaliana	Maize
M. truncatula	Rice (japonica)	Rice (indica)

Or input other organisms

iPTMnet Report for P17948 (FLT1)

Protein Information

Interactive Sequence View

P17948 (FLT1) as Substrate

P17948 (FLT1) as PTM Enzyme

PTM sites affected in variants