Protein Information

Cytoscape View


UniProt AC / UniProt ID P17936 / IBP3_HUMAN
Protein Name Insulin-like growth factor-binding protein 3 precursor
Gene Name Name: IGFBP3
Synonyms:IBP3;
Organism Homo sapiens (Human)

PRO ID PR:P17936
DAG View
PRO Name insulin-like growth factor-binding protein 3 (human)
Definition An insulin-like growth factor-binding protein 3 that is encoded in the genome of human.
Short Label hIGFBP3
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P17936 (IGFBP3) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
T7 Phosphorylation PhosphoSitePlus
N116 N-Glycosylation GlyGen   UniProt 23090970, 19139490, 29671580, ...29391424, 24190977
N136 N-Glycosylation GlyGen   UniProt 16335952, 19159218, 24190977, ...23090970, 14760718, 29391424, 19139490
S138 Phosphorylation P68400 (CSNK2A1) phospho.ELM   PhosphoSitePlus   Signor 12210764, 10650937
S140 Phosphorylation P68400 (CSNK2A1) phospho.ELM   PhosphoSitePlus   Signor 12210764, 10650937
S145 Phosphorylation PhosphoSitePlus
S148 O-Glycosylation GlyGen   PhosphoSitePlus 30459171
S148 Phosphorylation PhosphoSitePlus   UniProt 26091039
S151 O-Glycosylation PhosphoSitePlus
S151 Phosphorylation PhosphoSitePlus
S153 O-Glycosylation PhosphoSitePlus
S155 O-Glycosylation PhosphoSitePlus
S156 O-Glycosylation PhosphoSitePlus
S156 Phosphorylation PhosphoSitePlus   RLIMS-P 17108124, 19556345
T157 O-Glycosylation PhosphoSitePlus
S161 O-Glycosylation PhosphoSitePlus
S170 Phosphorylation PhosphoSitePlus
S183 Phosphorylation P78527 (PRKDC) PhosphoSitePlus 23557743
Y190 Phosphorylation PhosphoSitePlus
S192 O-Glycosylation PhosphoSitePlus
S194 Phosphorylation P68400 (CSNK2A1) PhosphoSitePlus 19556345
T195 O-Glycosylation GlyGen   PhosphoSitePlus 30459171
T197 Phosphorylation PhosphoSitePlus
N199 N-Glycosylation GlyGen   UniProt 16335952, 24190977, 23090970, ...29391424, 19139490, 29671580
S201 Phosphorylation PhosphoSitePlus   UniProt 26091039
Y210 Phosphorylation PhosphoSitePlus
S231 Phosphorylation PhosphoSitePlus
Y246 Phosphorylation PhosphoSitePlus
T277 O-Glycosylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S138 Phosphorylation P68400 (CSNK2A1) HPRD 10650937
S140 Phosphorylation P68400 (CSNK2A1) HPRD 10650937
S201 Phosphorylation HPRD 19824718
Site PTM Type PTM Enzyme Score Source PMID
S144 Phosphorylation P68400 (CSNK2A1) HPRD 10650937
S146 Phosphorylation P68400 (CSNK2A1) HPRD 10650937
S207 Phosphorylation HPRD 19824718


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T7 M7 Biomuta DOID:1909 / melanoma [ cosmic ]
S140 * Biomuta DOID:10534 / stomach cancer [ cosmic, icgc, tcga ]
S140 L140 Biomuta DOID:1793 / pancreatic cancer [ tcga ] DOID:1909 / melanoma [ cosmic ]
S153 P153 Biomuta DOID:3963 / thyroid carcinoma [ cosmic, icgc ]
S153 Y153 Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
S155 P155 Biomuta DOID:3963 / thyroid carcinoma [ cosmic, icgc ]
T157 K157 Biomuta DOID:1324 / lung cancer [ cosmic, icgc, tcga ]
S161 A161 Biomuta DOID:363 / uterine cancer [ tcga ]
T197 N197 Biomuta DOID:263 / kidney cancer [ tcga ]
T197 I197 Biomuta DOID:363 / uterine cancer [ tcga ]
N199 S199 Biomuta DOID:1324 / lung cancer [ tcga ]