iPTMnet Report for P17931 (LGALS3)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P17931 / LEG3_HUMAN
Protein Name Galectin-3
Gene Name Name: LGALS3
Synonyms:MAC2;
Organism Homo sapiens (Human)

PRO ID PR:P17931
DAG View
PRO Name galectin-3 (human)
Definition A galectin-3 that is encoded in the genome of human.
Short Label hLGALS3
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P17931 (LGALS3) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S6 Phosphorylation P48729 (CSNK1A1) , P68400 (CSNK2A1) , P19784 (CSNK2A2) HPRD   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 26911284, 18302943, 10961987, ...19453521, 15121858, 8253806, 16322222
S12 Phosphorylation P68400 (CSNK2A1) , P19784 (CSNK2A2) , P48729 (CSNK1A1) HPRD   phospho.ELM   PhosphoSitePlus   UniProt 18302943, 8253806
Y79 Phosphorylation P00519 (ABL1) , P42684 (ABL2) neXtProt   PhosphoSitePlus   RLIMS-P   Signor 20150913, 20600357
S96 Phosphorylation RLIMS-P 26752347
Y107 Phosphorylation P00519 (ABL1) neXtProt   PhosphoSitePlus   RLIMS-P   Signor 22232548, 20600357
Y118 Phosphorylation P00519 (ABL1) , P42684 (ABL2) neXtProt   PhosphoSitePlus   RLIMS-P   Signor 20150913, 20600357
T133 Phosphorylation HPRD 20068231
C173 Methylation IEDB 31844290
T175 Phosphorylation PhosphoSitePlus
K176 Acetylation PhosphoSitePlus
K176 Ubiquitination PhosphoSitePlus
S188 Phosphorylation PhosphoSitePlus   UniProt 23186163
K196 Ubiquitination PhosphoSitePlus
K210 Acetylation PhosphoSitePlus
K210 Ubiquitination PhosphoSitePlus
Y221 Phosphorylation PhosphoSitePlus
K227 Acetylation PhosphoSitePlus
K227 Ubiquitination PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S6 L6 Biomuta DOID:4159 / skin cancer [ cosmic ]
K210 R210 Biomuta DOID:10283 / prostate cancer [ cosmic ]
Y221 H221 Biomuta DOID:9256 / colorectal cancer [ cosmic ]