iPTMnet Report for P17861 (XBP1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P17861 / XBP1_HUMAN
Protein Name X-box-binding protein 1
Gene Name Name: XBP1
Synonyms:TREB5;
Organism Homo sapiens (Human)

PRO ID PR:P17861
DAG View
PRO Name X-box-binding protein 1 (human)
Definition An X-box-binding protein 1 that is encoded in the genome of human.
Short Label hXBP1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P17861 (XBP1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S47 Phosphorylation PhosphoSitePlus   UniProt 23186163
K60 Ubiquitination PhosphoSitePlus
S68 Phosphorylation neXtProt   PhosphoSitePlus   UniProt 21892182, 23186163, 23277279
S68 Phosphorylation P27361 (MAPK3) PhosphoSitePlus 23277279
S68 Phosphorylation P28482 (MAPK1) PhosphoSitePlus 23277279
S68 Phosphorylation Q16539 (MAPK14) neXtProt 21892182
K72 Ubiquitination PhosphoSitePlus
K77 Ubiquitination PhosphoSitePlus
S96 Phosphorylation PhosphoSitePlus
K111 Ubiquitination PhosphoSitePlus
K122 Ubiquitination PhosphoSitePlus
K151 Ubiquitination PhosphoSitePlus
S181 Phosphorylation PhosphoSitePlus 23277279
S181 Phosphorylation P27361 (MAPK3) PhosphoSitePlus 23277279
S181 Phosphorylation P28482 (MAPK1) PhosphoSitePlus 23277279
K236 Ubiquitination PhosphoSitePlus
S255 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S47 Phosphorylation HPRD 19413330
Site PTM Type PTM Enzyme Score Source PMID
S47 Phosphorylation HPRD 19413330
K262 Ubiquitination PhosphoSitePlus
S288 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S47 R47 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
K72 R72 Biomuta DOID:1612 / breast cancer [ icgc ]
K77 T77 Biomuta DOID:4159 / skin cancer [ cosmic ]
K262 M262 Biomuta DOID:2394 / ovarian cancer [ cosmic, icgc ] DOID:2531 / hematologic cancer [ cosmic ]