iPTMnet Report for P17858 (PFKL)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P17858 / PFKAL_HUMAN
Protein Name ATP-dependent 6-phosphofructokinase, liver type
Gene Name Name: PFKL
Organism Homo sapiens (Human)

PRO ID PR:P17858
DAG View
PRO Name ATP-dependent 6-phosphofructokinase, liver type (human)
Definition An ATP-dependent 6-phosphofructokinase, liver type that is encoded in the genome of human.
Short Label hPFKL
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P17858 (PFKL) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
A2 Acetylation UniProt 22814378, 22223895
K8 Ubiquitination PhosphoSitePlus
K16 Ubiquitination PhosphoSitePlus
Y43 Phosphorylation PhosphoSitePlus
T93 Phosphorylation PhosphoSitePlus
K144 Ubiquitination PhosphoSitePlus
T202 Phosphorylation PhosphoSitePlus
K272 Ubiquitination PhosphoSitePlus
K280 Ubiquitination PhosphoSitePlus
R301 Methylation PhosphoSitePlus
T304 Phosphorylation PhosphoSitePlus
R310 Methylation PhosphoSitePlus
K356 Ubiquitination PhosphoSitePlus
K365 Ubiquitination PhosphoSitePlus
R374 Methylation PhosphoSitePlus
S377 Phosphorylation PhosphoSitePlus
K386 Ubiquitination PhosphoSitePlus
K392 Ubiquitination PhosphoSitePlus
K395 Ubiquitination PhosphoSitePlus
K397 Ubiquitination PhosphoSitePlus
N399 N-Glycosylation GlyGen 29671580
R461 Methylation PhosphoSitePlus
S464 Phosphorylation PhosphoSitePlus
T468 Phosphorylation PhosphoSitePlus
K469 Acetylation PhosphoSitePlus
K469 Ubiquitination PhosphoSitePlus
T471 Phosphorylation PhosphoSitePlus
K474 Ubiquitination PhosphoSitePlus
S479 Phosphorylation PhosphoSitePlus
S529 O-Glycosylation GlyGen   UniProt 22923583, 34725712, 35138101, ...33214551, 34019948
K556 Ubiquitination PhosphoSitePlus
K563 Acetylation PhosphoSitePlus
K614 Ubiquitination PhosphoSitePlus
K616 Ubiquitination PhosphoSitePlus
K629 Ubiquitination PhosphoSitePlus
Y633 Phosphorylation PhosphoSitePlus
Y634 Phosphorylation PhosphoSitePlus
Y640 Phosphorylation PhosphoSitePlus
C653 Methylation IEDB 31844290
R654 Methylation PhosphoSitePlus
R672 Methylation PhosphoSitePlus
Y674 Phosphorylation PhosphoSitePlus
K677 Ubiquitination PhosphoSitePlus
K689 Acetylation PhosphoSitePlus
Y694 Phosphorylation PhosphoSitePlus
C708 Methylation IEDB 31844290
K713 Ubiquitination PhosphoSitePlus
K715 Ubiquitination PhosphoSitePlus
K726 Acetylation PhosphoSitePlus
K726 Ubiquitination PhosphoSitePlus
K727 Acetylation PhosphoSitePlus
S763 Phosphorylation PhosphoSitePlus
T773 Phosphorylation phospho.ELM   PhosphoSitePlus 8670219
S775 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
K778 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
N399 N-Glycosylation PRO 29671580
Y633 Phosphorylation HPRD 15592455
S757 Phosphorylation HPRD 20068231
T770 Phosphorylation HPRD 20068231
S775 Phosphorylation HPRD 20166139, 18691976, 18669648, ...20068231
Site PTM Type PTM Enzyme Score Source PMID
Y90 Phosphorylation PhosphoSitePlus
Y680 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T304 M304 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
T304 S304 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
R310 Q310 Biomuta DOID:263 / kidney cancer [ cosmic, icgc ]
R374 H374 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
R461 H461 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
R461 C461 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K563 R563 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]
Y633 H633 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
C653 F653 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
K677 R677 Biomuta DOID:1324 / lung cancer [ cosmic ]
Y694 H694 Biomuta [ cosmic ]
S763 L763 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
T770 P770 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
T773 N773 Biomuta DOID:10283 / prostate cancer [ cosmic ]