iPTMnet Report for P17844 (DDX5)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P17844 / DDX5_HUMAN
Protein Name Probable ATP-dependent RNA helicase DDX5
Gene Name Name: DDX5
Synonyms:G17P1,HELR,HLR1;
Organism Homo sapiens (Human)

PRO ID PR:P17844
DAG View
PRO Name probable ATP-dependent RNA helicase DDX5 (human)
Definition A probable ATP-dependent RNA helicase DDX5 that is encoded in the genome of human.
Short Label hDDX5
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P17844 (DDX5) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S2 Phosphorylation RLIMS-P 23349811
S5 Phosphorylation RLIMS-P 23349811
S6 Phosphorylation PhosphoSitePlus
R10 Methylation PhosphoSitePlus
R12 Methylation PhosphoSitePlus
R14 Methylation PhosphoSitePlus
R20 Methylation PhosphoSitePlus
S24 Phosphorylation PhosphoSitePlus   UniProt 23186163
R25 Methylation PhosphoSitePlus
S30 Phosphorylation PhosphoSitePlus
K32 Acetylation PhosphoSitePlus   UniProt 19608861
K32 Ubiquitination PhosphoSitePlus
K33 Acetylation PhosphoSitePlus   UniProt 19608861
K33 Ubiquitination PhosphoSitePlus
K40 Acetylation PhosphoSitePlus   UniProt 19608861
K40 Sumoylation PhosphoSitePlus
K40 Ubiquitination PhosphoSitePlus
K43 Acetylation PhosphoSitePlus
K44 Acetylation PhosphoSitePlus
K45 Acetylation PhosphoSitePlus
K45 Sumoylation PhosphoSitePlus
K45 Ubiquitination PhosphoSitePlus
K53 Acetylation PhosphoSitePlus
K53 Sumoylation PhosphoSitePlus
K53 Ubiquitination PhosphoSitePlus
K56 Acetylation PhosphoSitePlus
K56 Methylation PhosphoSitePlus
K56 Sumoylation PhosphoSitePlus
K56 Ubiquitination PhosphoSitePlus
Y59 Phosphorylation PhosphoSitePlus
T69 Phosphorylation PhosphoSitePlus
S79 O-Glycosylation GlyGen 30444036, 32522876, 35138101, ...34019948, 30397120, 30379171, 34725712, 28510447, 33214551, 35254053, 30484950, 35132862, 35083852, 22967762, 32119511, 29351928
S79 Phosphorylation PhosphoSitePlus
K80 Acetylation PhosphoSitePlus
K80 Ubiquitination PhosphoSitePlus
T83 Phosphorylation PhosphoSitePlus
C89 Methylation IEDB 31844290
K91 Ubiquitination PhosphoSitePlus
Y97 Phosphorylation PhosphoSitePlus
K144 Ubiquitination PhosphoSitePlus
C170 Methylation IEDB 31844290
Y190 Phosphorylation PhosphoSitePlus
K197 Methylation PhosphoSitePlus
K197 Ubiquitination PhosphoSitePlus
S198 Phosphorylation neXtProt   PhosphoSitePlus 23482664
S198 Phosphorylation P49137 (MAPKAPK2) neXtProt   PhosphoSitePlus 23482664
T199 Phosphorylation PhosphoSitePlus
C200 Methylation IEDB 31844290
C200 S-Nitrosylation dbSNO 19483679, 26338901
Y202 Phosphorylation phospho.ELM   PhosphoSitePlus 18083107
K207 Sumoylation PhosphoSitePlus
K207 Ubiquitination PhosphoSitePlus
T224 Phosphorylation PhosphoSitePlus
C234 Methylation IEDB 31844290
C234 S-Nitrosylation dbSNO 19483679
K236 Acetylation PhosphoSitePlus
K236 Ubiquitination PhosphoSitePlus
T243 Phosphorylation PhosphoSitePlus
Y244 Phosphorylation phospho.ELM   PhosphoSitePlus 16097034
R263 Methylation PhosphoSitePlus
K264 Acetylation PhosphoSitePlus
K264 Ubiquitination PhosphoSitePlus
R273 Methylation PhosphoSitePlus
S279 Phosphorylation PhosphoSitePlus
K284 Ubiquitination PhosphoSitePlus
Y297 Phosphorylation PhosphoSitePlus   UniProt 15592455
K328 Ubiquitination PhosphoSitePlus
S338 Phosphorylation PhosphoSitePlus
K340 Acetylation PhosphoSitePlus
K340 Methylation PhosphoSitePlus
K340 Ubiquitination PhosphoSitePlus
K343 Sumoylation PhosphoSitePlus
K343 Ubiquitination PhosphoSitePlus
T344 Phosphorylation PhosphoSitePlus
K351 Acetylation PhosphoSitePlus
K351 Ubiquitination PhosphoSitePlus
K375 Ubiquitination PhosphoSitePlus
K388 Acetylation PhosphoSitePlus
K388 Ubiquitination PhosphoSitePlus
K391 Sumoylation PhosphoSitePlus
K391 Ubiquitination PhosphoSitePlus
S402 Phosphorylation PhosphoSitePlus
R403 Methylation PhosphoSitePlus
K411 Sumoylation PhosphoSitePlus
K411 Ubiquitination PhosphoSitePlus
Y416 Phosphorylation PhosphoSitePlus
S421 Phosphorylation PhosphoSitePlus
Y425 Phosphorylation PhosphoSitePlus
K437 Sumoylation PhosphoSitePlus
K437 Ubiquitination PhosphoSitePlus
T438 Phosphorylation PhosphoSitePlus
T440 Phosphorylation PhosphoSitePlus
Y442 Phosphorylation PhosphoSitePlus
T446 Phosphorylation neXtProt   PhosphoSitePlus   RLIMS-P 23110695
T446 Phosphorylation Q16539 (MAPK14) PhosphoSitePlus 23110695
K451 Ubiquitination PhosphoSitePlus
S454 Phosphorylation PhosphoSitePlus
S458 Phosphorylation PhosphoSitePlus
K470 Acetylation PhosphoSitePlus
K470 Sumoylation PhosphoSitePlus
K470 Ubiquitination PhosphoSitePlus
R478 Methylation PhosphoSitePlus
S480 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 23186163, 18220336, ...18669648, 20068231
R482 Methylation PhosphoSitePlus
S483 Phosphorylation PhosphoSitePlus
R484 Methylation PhosphoSitePlus
R486 Methylation PhosphoSitePlus
K490 Methylation PhosphoSitePlus
R496 Methylation PhosphoSitePlus
S498 Phosphorylation PhosphoSitePlus
K501 Acetylation PhosphoSitePlus
R502 Methylation IEDB   PhosphoSitePlus 27503676
T507 Phosphorylation phospho.ELM   PhosphoSitePlus 17287340
R509 Methylation PhosphoSitePlus
Y514 Phosphorylation PhosphoSitePlus
R516 Methylation PhosphoSitePlus
Y518 Phosphorylation PhosphoSitePlus
S519 Phosphorylation PhosphoSitePlus
S520 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 23186163, 17287340
K523 Sumoylation PhosphoSitePlus
K523 Ubiquitination PhosphoSitePlus
Y535 Phosphorylation PhosphoSitePlus
S536 O-Glycosylation GlyGen 30444036, 32522876, 35138101, ...34019948, 30397120, 30379171, 34725712, 28510447, 33214551, 35254053, 30484950, 35132862, 35083852, 22967762, 32119511, 29351928
S544 O-Glycosylation GlyGen 30444036, 32522876, 35138101, ...34019948, 30397120, 30379171, 34725712, 28510447, 33214551, 35254053, 30484950, 35132862, 35083852, 22967762, 32119511, 29351928
S551 O-Glycosylation GlyGen 30444036, 32522876, 35138101, ...34019948, 30397120, 30379171, 34725712, 28510447, 33214551, 35254053, 30484950, 35132862, 35083852, 22967762, 32119511, 29351928
S557 O-Glycosylation GlyGen 30444036, 32522876, 35138101, ...34019948, 30397120, 30379171, 34725712, 28510447, 33214551, 35254053, 30484950, 35132862, 35083852, 22967762, 32119511, 29351928
S557 Phosphorylation phospho.ELM 7525583
T564 Phosphorylation neXtProt   PhosphoSitePlus   RLIMS-P 23110695
T564 Phosphorylation Q16539 (MAPK14) PhosphoSitePlus 23110695
Y593 Phosphorylation neXtProt   PhosphoSitePlus   RLIMS-P   Signor 20676135, 19786986, 11823473, ...23322042, 17018282, 17412694, 17384675
Y593 Phosphorylation P00519 (ABL1) neXtProt   PhosphoSitePlus   Signor 11823473, 17018282
Y595 Phosphorylation neXtProt   PhosphoSitePlus 17384675
Site PTM Type PTM Enzyme Score Source PMID
S6 Phosphorylation HPRD 19651622, 20068231
S30 Phosphorylation HPRD 17924679
T224 Phosphorylation HPRD 20068231
Y297 Phosphorylation HPRD 15592455
S480 Phosphorylation HPRD 18691976, 18669648, 20068231
S498 Phosphorylation HPRD 20068231
T507 Phosphorylation HPRD 17287340, 18212344
S519 Phosphorylation HPRD 20068231
S520 Phosphorylation HPRD 17287340, 18212344
S557 Phosphorylation HPRD 7525583
S557 Phosphorylation P17252 (PRKCA) HPRD 7525583


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K33 M33 Biomuta DOID:2394 / ovarian cancer [ icgc ]
K144 E144 Biomuta DOID:4159 / skin cancer [ icgc ]