Protein Information

Cytoscape View


UniProt AC / UniProt ID P17812 / PYRG1_HUMAN
Protein Name CTP synthase 1
Gene Name Name: CTPS1
Synonyms:CTPS;
Organism Homo sapiens (Human)

PRO ID PR:P17812
DAG View
PRO Name CTP synthase 1 (human)
Definition A CTP synthase 1 that is encoded in the genome of human.
Short Label hCTPS1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P17812 (CTPS1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S12 Phosphorylation PhosphoSitePlus
S22 Phosphorylation PhosphoSitePlus
Y53 Phosphorylation PhosphoSitePlus
R81 Methylation PhosphoSitePlus
K84 Ubiquitination PhosphoSitePlus
K92 Acetylation PhosphoSitePlus
K92 Ubiquitination PhosphoSitePlus
Y94 Phosphorylation PhosphoSitePlus
Y96 Phosphorylation PhosphoSitePlus
K100 Acetylation PhosphoSitePlus   UniProt 19608861
K100 Ubiquitination PhosphoSitePlus
K103 Ubiquitination PhosphoSitePlus
Y106 Phosphorylation PhosphoSitePlus
K169 Methylation PhosphoSitePlus
K169 Ubiquitination PhosphoSitePlus
K171 Acetylation PhosphoSitePlus
K195 Ubiquitination PhosphoSitePlus
R205 Methylation PhosphoSitePlus
S210 Phosphorylation PhosphoSitePlus
K227 Ubiquitination PhosphoSitePlus
S231 Phosphorylation PhosphoSitePlus
Y265 Phosphorylation PhosphoSitePlus
K286 Acetylation PhosphoSitePlus
K286 Ubiquitination PhosphoSitePlus
K306 Acetylation PhosphoSitePlus
K306 Ubiquitination PhosphoSitePlus
Y307 Phosphorylation PhosphoSitePlus
K309 Acetylation PhosphoSitePlus
K309 Ubiquitination PhosphoSitePlus
K319 Ubiquitination PhosphoSitePlus
K331 Ubiquitination PhosphoSitePlus
K335 Ubiquitination PhosphoSitePlus
T346 Phosphorylation PhosphoSitePlus
S347 Phosphorylation PhosphoSitePlus
K360 Ubiquitination PhosphoSitePlus
C362 S-Nitrosylation dbSNO 19483679
K381 Ubiquitination PhosphoSitePlus
R389 Methylation PhosphoSitePlus
N420 N-Glycosylation GlyGen 29671580
T428 Phosphorylation PhosphoSitePlus
T447 Phosphorylation PhosphoSitePlus
T455 Phosphorylation P17612 (PRKACA) , P17252 (PRKCA) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor 17463002, 17189248
K460 Acetylation PhosphoSitePlus
K460 Ubiquitination PhosphoSitePlus
S462 Phosphorylation P17252 (PRKCA) phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor 17463002
K466 Acetylation PhosphoSitePlus
K466 Ubiquitination PhosphoSitePlus
Y473 Phosphorylation PhosphoSitePlus
R477 Methylation PhosphoSitePlus
K489 Methylation PhosphoSitePlus
K489 Ubiquitination PhosphoSitePlus
K490 Methylation PhosphoSitePlus
K490 Ubiquitination PhosphoSitePlus
K498 Ubiquitination PhosphoSitePlus
K535 Ubiquitination PhosphoSitePlus
S552 Phosphorylation PhosphoSitePlus
K557 Ubiquitination PhosphoSitePlus
S562 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 17081983
T566 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
Y567 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S568 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 18088087
R570 Methylation PhosphoSitePlus
S571 Phosphorylation P49840 (GSK3A) phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 18088087, 17681942, 16097034, ...18669648, 19690332
S573 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 16097034, 18669648, 18088087, ...21406692
S574 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 18088087, 17681942, 16097034, ...18669648, 19690332, 20068231
S575 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 21406692, 16083285, 18088087, ...17681942, 18220336, 15302935, 18669648, 23186163, 19690332, 20068231
S578 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
T581 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
K584 Sumoylation PhosphoSitePlus
K584 Ubiquitination PhosphoSitePlus
S587 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
Site PTM Type PTM Enzyme Score Source PMID
Y106 Phosphorylation HPRD 20068231
Y540 Phosphorylation HPRD 20068231
S562 Phosphorylation HPRD 17322306, 20068231
T566 Phosphorylation HPRD 19651622, 18691976, 18669648, ...17081983
Y567 Phosphorylation HPRD 18669648, 17081983
S568 Phosphorylation HPRD 19413330, 18088087, 17081983, ...18767875, 18452278, 19651622, 18669648, 20068231
S571 Phosphorylation HPRD 19413330, 18691976, 18491316, ...18088087, 17081983, 18452278, 19651622, 18669648, 20068231
S573 Phosphorylation HPRD 18691976, 18491316, 18088087, ...19664995, 18452278, 19651622, 17322306, 18669648, 20068231
S574 Phosphorylation HPRD 19413330, 18691976, 18491316, ...18088087, 20230923, 19651622, 18452278, 17322306, 18669648, 19415658, 20068231
S575 Phosphorylation HPRD 19413330, 18691976, 18491316, ...18088087, 20230923, 18767875, 19664994, 19664995, 18452278, 17322306, 18669648, 19651622, 20058876, 18707149, 19415658, 20068231
S578 Phosphorylation HPRD 19651622, 18669648, 18491316, ...17081983, 18452278
T581 Phosphorylation HPRD 18669648, 17081983, 20068231, ...18452278
S587 Phosphorylation HPRD 18669648


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
R81 H81 Biomuta DOID:363 / uterine cancer [ tcga ]
K100 N100 Biomuta DOID:3070 / malignant glioma [ tcga ]
R205 K205 Biomuta DOID:1324 / lung cancer [ cosmic, tcga ]
K319 R319 Biomuta DOID:3963 / thyroid carcinoma [ cosmic, icgc ]
R389 W389 Biomuta DOID:1909 / melanoma [ cosmic ]
N420 S420 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc, tcga ]
T447 I447 Biomuta DOID:0070003 / blastoma [ cosmic ]
K460 N460 Biomuta DOID:9256 / colorectal cancer [ icgc ]
T566 I566 Biomuta DOID:1115 / sarcoma [ tcga ]
R570 K570 Biomuta DOID:0060119 / pharynx cancer [ cosmic ]
T581 I581 Biomuta DOID:363 / uterine cancer [ tcga ]