iPTMnet Report for P17706 (PTPN2)
Protein Information
UniProt AC / UniProt ID | P17706 / PTN2_HUMAN |
Protein Name | Tyrosine-protein phosphatase non-receptor type 2 |
Gene Name | Name: PTPN2 Synonyms:PTPT; |
Organism | Homo sapiens (Human) |
PRO ID | PR:P17706 |
PRO Name | tyrosine-protein phosphatase non-receptor type 2 (human) |
Definition | A tyrosine-protein phosphatase non-receptor type 2 that is encoded in the genome of human. |
Short Label | hPTPN2 |
Category | organism-gene |
P17706 (PTPN2) as Substrate
Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
---|---|---|---|---|---|---|
Y22 | Phosphorylation | score1 | PhosphoSitePlus | |||
Y32 | Phosphorylation | score1 | PhosphoSitePlus | |||
K38 | Acetylation | score1 | PhosphoSitePlus | |||
K38 | Ubiquitination | score1 | PhosphoSitePlus | |||
S52 | Phosphorylation | score1 | PhosphoSitePlus | |||
Y54 | Phosphorylation | score1 | PhosphoSitePlus | |||
K60 | Ubiquitination | score1 | PhosphoSitePlus | |||
Y68 | Phosphorylation | score1 | PhosphoSitePlus | |||
S72 | Phosphorylation | score1 | PhosphoSitePlus | |||
K122 | Ubiquitination | score1 | PhosphoSitePlus | |||
K137 | Ubiquitination | score1 | PhosphoSitePlus | |||
K144 | Ubiquitination | score1 | PhosphoSitePlus | |||
T179 | O-Glycosylation | score1 | GlyGen | 34019948, 35132862, 29351928 | ||
K245 | Ubiquitination | score1 | PhosphoSitePlus | |||
T261 | Phosphorylation | score1 | PhosphoSitePlus | |||
K280 | Ubiquitination | score1 | PhosphoSitePlus | |||
K287 | Ubiquitination | score1 | PhosphoSitePlus | |||
S293 | Phosphorylation | score2 | PhosphoSitePlus UniProt | 23186163 | ||
K294 | Ubiquitination | score1 | PhosphoSitePlus | |||
S298 | Phosphorylation | score2 | phospho.ELM PhosphoSitePlus UniProt | 18669648, 23186163, 24275569 | ||
S304 | Phosphorylation | score4 | neXtProt phospho.ELM PhosphoSitePlus RLIMS-P Signor UniProt | 21406692, 23186163, 15030318, ... | ||
S304 | Phosphorylation | P06493 (CDK1) | score3 | neXtProt Signor | 15030318 | |
S304 | Phosphorylation | P24941 (CDK2) | score1 | Signor | 15030318 | |
K307 | Ubiquitination | score1 | PhosphoSitePlus | |||
T310 | Phosphorylation | score1 | PhosphoSitePlus | |||
K312 | Acetylation | score1 | PhosphoSitePlus | |||
K312 | Ubiquitination | score1 | PhosphoSitePlus | |||
K324 | Ubiquitination | score1 | PhosphoSitePlus | |||
T326 | O-Glycosylation | score1 | GlyGen | 34019948, 35132862, 29351928 | ||
S334 | O-Glycosylation | score1 | GlyGen | 34019948, 35132862, 29351928 | ||
K336 | Ubiquitination | score1 | PhosphoSitePlus | |||
T340 | Phosphorylation | score1 | PhosphoSitePlus | |||
S347 | Phosphorylation | score1 | PhosphoSitePlus | |||
K364 | Ubiquitination | score1 | PhosphoSitePlus | |||
Y384 | Phosphorylation | score1 | PhosphoSitePlus |
Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
---|---|---|---|---|---|---|
S298 | Phosphorylation | score0 | HPRD | 19413330, 19651622, 18669648, ... | ||
S304 | Phosphorylation | score4 | HPRD neXtProt phospho.ELM PhosphoSitePlus | 19413330, 18767875, 19651622, ... | ||
S304 | Phosphorylation | P06493 (CDK1) | score4 | HPRD phospho.ELM PhosphoSitePlus | 19413330, 18767875, 19651622, ... | |
S304 | Phosphorylation | P24941 (CDK2) | score4 | HPRD PhosphoSitePlus | 19413330, 18767875, 19651622, ... | |
S304 | Phosphorylation | Q00535 (CDK5) | score2 | HPRD | 19413330, 18767875, 19651622, ... |
Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
---|---|---|---|---|---|---|
S298 | Phosphorylation | score0 | HPRD | 19413330, 19651622, 18669648, ... | ||
S304 | Phosphorylation | score2 | HPRD | 19413330, 18767875, 19651622, ... | ||
S304 | Phosphorylation | P06493 (CDK1) | score2 | HPRD | 19413330, 18767875, 19651622, ... | |
S304 | Phosphorylation | P24941 (CDK2) | score2 | HPRD | 19413330, 18767875, 19651622, ... | |
S304 | Phosphorylation | Q00535 (CDK5) | score2 | HPRD | 19413330, 18767875, 19651622, ... |
PTM sites affected in variants
Site | Variant | Source | PMID | Disease [Sample source] |
---|---|---|---|---|
K122 | R122 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] | |
T179 | I179 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] | |
T261 | A261 | Biomuta | DOID:10534 / stomach cancer [ cosmic ] DOID:263 / kidney cancer [ cosmic, icgc ] | |
T261 | N261 | Biomuta | DOID:4159 / skin cancer [ cosmic, icgc ] | |
K280 | R280 | Biomuta | DOID:9256 / colorectal cancer [ cosmic ] | |
K287 | T287 | Biomuta | DOID:3571 / liver cancer [ cosmic, icgc ] | |
S298 | Y298 | Biomuta | DOID:9256 / colorectal cancer [ cosmic, icgc ] | |
S298 | C298 | Biomuta | DOID:11054 / urinary bladder cancer [ cosmic, icgc ] | |
T326 | A326 | Biomuta | DOID:263 / kidney cancer [ cosmic ] | |
K336 | E336 | Biomuta | DOID:4159 / skin cancer [ cosmic ] | |
T340 | K340 | Biomuta | DOID:363 / uterine cancer [ cosmic, icgc ] DOID:9256 / colorectal cancer [ cosmic, icgc, cosmic, icgc ] DOID:11054 / urinary bladder cancer [ cosmic, icgc, cosmic, icgc ] |