iPTMnet Report for P17706 (PTPN2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P17706 / PTN2_HUMAN
Protein Name Tyrosine-protein phosphatase non-receptor type 2
Gene Name Name: PTPN2
Synonyms:PTPT;
Organism Homo sapiens (Human)

PRO ID PR:P17706
DAG View
PRO Name tyrosine-protein phosphatase non-receptor type 2 (human)
Definition A tyrosine-protein phosphatase non-receptor type 2 that is encoded in the genome of human.
Short Label hPTPN2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P17706 (PTPN2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
Y22 Phosphorylation PhosphoSitePlus
Y32 Phosphorylation PhosphoSitePlus
K38 Acetylation PhosphoSitePlus
K38 Ubiquitination PhosphoSitePlus
S52 Phosphorylation PhosphoSitePlus
Y54 Phosphorylation PhosphoSitePlus
K60 Ubiquitination PhosphoSitePlus
Y68 Phosphorylation PhosphoSitePlus
S72 Phosphorylation PhosphoSitePlus
K122 Ubiquitination PhosphoSitePlus
K137 Ubiquitination PhosphoSitePlus
K144 Ubiquitination PhosphoSitePlus
T179 O-Glycosylation GlyGen 34019948, 35132862, 29351928
K245 Ubiquitination PhosphoSitePlus
T261 Phosphorylation PhosphoSitePlus
K280 Ubiquitination PhosphoSitePlus
K287 Ubiquitination PhosphoSitePlus
S293 Phosphorylation PhosphoSitePlus   UniProt 23186163
K294 Ubiquitination PhosphoSitePlus
S298 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 24275569
S304 Phosphorylation neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 21406692, 23186163, 15030318, ...18669648, 24275569, 7593185, 20068231
S304 Phosphorylation P06493 (CDK1) neXtProt   Signor 15030318
S304 Phosphorylation P24941 (CDK2) Signor 15030318
K307 Ubiquitination PhosphoSitePlus
T310 Phosphorylation PhosphoSitePlus
K312 Acetylation PhosphoSitePlus
K312 Ubiquitination PhosphoSitePlus
K324 Ubiquitination PhosphoSitePlus
T326 O-Glycosylation GlyGen 34019948, 35132862, 29351928
S334 O-Glycosylation GlyGen 34019948, 35132862, 29351928
K336 Ubiquitination PhosphoSitePlus
T340 Phosphorylation PhosphoSitePlus
S347 Phosphorylation PhosphoSitePlus
K364 Ubiquitination PhosphoSitePlus
Y384 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S298 Phosphorylation HPRD 19413330, 19651622, 18669648, ...20068231
S304 Phosphorylation HPRD   neXtProt   phospho.ELM   PhosphoSitePlus 19413330, 18767875, 19651622, ...15030318, 18669648, 20068231
S304 Phosphorylation P06493 (CDK1) HPRD   phospho.ELM   PhosphoSitePlus 19413330, 18767875, 19651622, ...15030318, 18669648, 20068231
S304 Phosphorylation P24941 (CDK2) HPRD   PhosphoSitePlus 19413330, 18767875, 19651622, ...15030318, 18669648, 20068231
S304 Phosphorylation Q00535 (CDK5) HPRD 19413330, 18767875, 19651622, ...15030318, 18669648, 20068231
Site PTM Type PTM Enzyme Score Source PMID
S298 Phosphorylation HPRD 19413330, 19651622, 18669648, ...20068231
S304 Phosphorylation HPRD 19413330, 18767875, 19651622, ...15030318, 18669648, 20068231
S304 Phosphorylation P06493 (CDK1) HPRD 19413330, 18767875, 19651622, ...15030318, 18669648, 20068231
S304 Phosphorylation P24941 (CDK2) HPRD 19413330, 18767875, 19651622, ...15030318, 18669648, 20068231
S304 Phosphorylation Q00535 (CDK5) HPRD 19413330, 18767875, 19651622, ...15030318, 18669648, 20068231


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K122 R122 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
T179 I179 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
T261 A261 Biomuta DOID:10534 / stomach cancer [ cosmic ] DOID:263 / kidney cancer [ cosmic, icgc ]
T261 N261 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
K280 R280 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K287 T287 Biomuta DOID:3571 / liver cancer [ cosmic, icgc ]
S298 Y298 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
S298 C298 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
T326 A326 Biomuta DOID:263 / kidney cancer [ cosmic ]
K336 E336 Biomuta DOID:4159 / skin cancer [ cosmic ]
T340 K340 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:9256 / colorectal cancer [ cosmic, icgc, cosmic, icgc ] DOID:11054 / urinary bladder cancer [ cosmic, icgc, cosmic, icgc ]