Protein Information

Cytoscape View

UniProt AC / UniProt ID P17676 / CEBPB_HUMAN
Protein Name CCAAT/enhancer-binding protein beta
Gene Name Name: CEBPB
Organism Homo sapiens (Human)

PRO ID PR:P17676
DAG View
PRO Name CCAAT/enhancer-binding protein beta (human)
Definition A CCAAT/enhancer-binding protein beta that is encoded in the genome of human.
Short Label hCEBPB
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species

P17676 (CEBPB) as Substrate

Site PTM Type PTM Enzyme Score Source PMID
R3 Methylation PhosphoSitePlus   UniProt 20111005
S65 Phosphorylation PhosphoSitePlus
S76 Phosphorylation P06493 (CDK1) neXtProt   PhosphoSitePlus 15314150
Y78 Phosphorylation P42684 (ABL2) , P00519 (ABL1) PhosphoSitePlus   Signor 19563810
K129 Ubiquitination PhosphoSitePlus
K133 Sumoylation PhosphoSitePlus
Y137 Phosphorylation PhosphoSitePlus
Y139 Phosphorylation PhosphoSitePlus
S141 Phosphorylation PhosphoSitePlus
K149 Ubiquitination PhosphoSitePlus
K174 Sumoylation PhosphoSitePlus
K185 Ubiquitination PhosphoSitePlus
K187 Sumoylation PhosphoSitePlus
Y213 Phosphorylation PhosphoSitePlus
S218 Phosphorylation PhosphoSitePlus
S223 Phosphorylation P49841 (GSK3B) PhosphoSitePlus 22080951
S225 Phosphorylation PhosphoSitePlus
T226 Phosphorylation P49841 (GSK3B) Signor 22369944
S229 Phosphorylation PhosphoSitePlus
S230 Phosphorylation PhosphoSitePlus
S231 Phosphorylation P49841 (GSK3B) PhosphoSitePlus   Signor 22369944, 17601773
T235 Phosphorylation Q9H2X6 (HIPK2) , Q15418 (RPS6KA1) , P27361 (MAPK3) , P28482 (MAPK1) , P24941 (CDK2) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P+   RLIMS-P   Signor   UniProt 22495929, 30808546, 16453302, ...24086653, 19327116, 16624284, 17601773, 12213825, 22369944, 16009338, 18052938, 18647749, 23782693, 8384717, 24277696, 23342250, 19723873, 21344389, 20818427, 24454781, 17540774, 20015877, 25402211, 11684016
Y249 Phosphorylation PhosphoSitePlus
S257 Phosphorylation PhosphoSitePlus
K260 Sumoylation PhosphoSitePlus
K260 Ubiquitination PhosphoSitePlus
K264 Acetylation PhosphoSitePlus
K265 Acetylation PhosphoSitePlus
T266 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P 28646679, 10635333
K269 Acetylation PhosphoSitePlus
K275 Sumoylation PhosphoSitePlus
K275 Ubiquitination PhosphoSitePlus
S288 Phosphorylation P17612 (PRKACA) phospho.ELM   PhosphoSitePlus   UniProt 9374525
K302 Ubiquitination PhosphoSitePlus
K315 Ubiquitination PhosphoSitePlus
K316 Ubiquitination PhosphoSitePlus
S321 Phosphorylation Q15349 (RPS6KA2) , P51812 (RPS6KA3) neXtProt 20351173
S325 Phosphorylation phospho.ELM   PhosphoSitePlus 1314426
K332 Sumoylation PhosphoSitePlus
K332 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S231 Phosphorylation HPRD 19413330, 8384717
T235 Phosphorylation P28482 (MAPK1) HPRD 19413330, 8384717
T266 Phosphorylation Q15418 (RPS6KA1) HPRD 10635333
S288 Phosphorylation HPRD 11726507
S325 Phosphorylation Q9UQM7 (CAMK2A) HPRD 1314426

PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
Y139 C139 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc, tcga ]
K174 M174 Biomuta DOID:1324 / lung cancer [ cosmic ]
K315 E315 Biomuta DOID:3571 / liver cancer [ icgc ]