iPTMnet Report for P17643 (TYRP1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P17643 / TYRP1_HUMAN
Protein Name 5,6-dihydroxyindole-2-carboxylic acid oxidase precursor
Gene Name Name: TYRP1
Synonyms:CAS2;
Organism Homo sapiens (Human)

PRO ID PR:P17643
DAG View
PRO Name 5,6-dihydroxyindole-2-carboxylic acid oxidase (human)
Definition A 5,6-dihydroxyindole-2-carboxylic acid oxidase that is encoded in the genome of human.
Short Label hTYRP1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P17643 (TYRP1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S46 Phosphorylation PhosphoSitePlus
N96 N-Glycosylation GlyGen   UniProt 28661582
N104 N-Glycosylation GlyGen   UniProt 28661582
S137 Phosphorylation PhosphoSitePlus
N181 N-Glycosylation GlyGen   UniProt 28661582
S207 Phosphorylation PhosphoSitePlus
T222 Phosphorylation PhosphoSitePlus
S270 Phosphorylation PhosphoSitePlus
N304 N-Glycosylation GlyGen   UniProt 28661582
N350 N-Glycosylation GlyGen   UniProt 28661582
N385 N-Glycosylation GlyGen   UniProt 28661582


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S137 N137 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
N304 H304 Biomuta DOID:11054 / urinary bladder cancer [ cosmic ]
N385 D385 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]