iPTMnet Report for P17542 (TAL1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P17542 / TAL1_HUMAN
Protein Name T-cell acute lymphocytic leukemia protein 1
Gene Name Name: TAL1
Synonyms:BHLHA17,SCL,TCL5;
Organism Homo sapiens (Human)

PRO ID PR:P17542
DAG View
PRO Name T-cell acute lymphocytic leukemia protein 1 (human)
Definition A T-cell acute lymphocytic leukemia protein 1 that is encoded in the genome of human.
Short Label hTAL1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P17542 (TAL1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S7 Phosphorylation PhosphoSitePlus
S12 Phosphorylation PhosphoSitePlus   UniProt 23186163
T90 Phosphorylation P31749 (AKT1) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor 19406989, 15930267
T91 Phosphorylation PhosphoSitePlus
S107 Phosphorylation PhosphoSitePlus
S122 Phosphorylation P27361 (MAPK3) , Q02750 (MAP2K1) , P17612 (PRKACA) phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 7970731, 23186163, 22310283, ...11904294, 8423803, 19690332
Y138 Phosphorylation PhosphoSitePlus
S139 Phosphorylation PhosphoSitePlus
S141 Phosphorylation PhosphoSitePlus
S146 Phosphorylation PhosphoSitePlus
S149 Phosphorylation PhosphoSitePlus
S172 Phosphorylation P17612 (PRKACA) phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor 9111058, 22310283
K212 Acetylation PhosphoSitePlus
T216 Phosphorylation PhosphoSitePlus
K221 Acetylation PhosphoSitePlus
K222 Acetylation PhosphoSitePlus
K222 Ubiquitination PhosphoSitePlus
K225 Acetylation PhosphoSitePlus
K225 Ubiquitination PhosphoSitePlus
K241 Ubiquitination PhosphoSitePlus
S316 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S122 Phosphorylation P27361 (MAPK3) HPRD 19651622, 8423803
S172 Phosphorylation HPRD 9111058


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation P17542 (TAL1) S172 P15923 (TCF3) unknown eFIP 9111058


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S7 N7 Biomuta DOID:1319 / brain cancer [ cosmic ]
S172 Y172 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
K225 M225 Biomuta DOID:10534 / stomach cancer [ cosmic ]