iPTMnet Report for P17516 (AKR1C4)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P17516 / AK1C4_HUMAN
Protein Name Aldo-keto reductase family 1 member C4
Gene Name Name: AKR1C4
Synonyms:CHDR;
Organism Homo sapiens (Human)

PRO ID PR:P17516
DAG View
PRO Name aldo-keto reductase family 1 member C4 (human)
Definition An aldo-keto reductase family 1 member C4 that is encoded in the genome of human.
Short Label hAKR1C4
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P17516 (AKR1C4) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K4 Acetylation PhosphoSitePlus
T23 Phosphorylation PhosphoSitePlus
Y24 Phosphorylation PhosphoSitePlus
K39 Methylation PhosphoSitePlus
Y53 Phosphorylation PhosphoSitePlus
K68 Acetylation PhosphoSitePlus
K68 Ubiquitination PhosphoSitePlus
S73 Phosphorylation PhosphoSitePlus
K75 Acetylation PhosphoSitePlus
K75 Sumoylation PhosphoSitePlus
K75 Ubiquitination PhosphoSitePlus
Y81 Phosphorylation PhosphoSitePlus
T82 Phosphorylation PhosphoSitePlus
S83 Phosphorylation PhosphoSitePlus
K84 Acetylation PhosphoSitePlus
K161 Ubiquitination PhosphoSitePlus
C170 Methylation IEDB 31844290
K179 Ubiquitination PhosphoSitePlus
K183 Ubiquitination PhosphoSitePlus
Y184 Phosphorylation PhosphoSitePlus
Y196 Phosphorylation PhosphoSitePlus
S200 Phosphorylation PhosphoSitePlus
K201 Acetylation PhosphoSitePlus
K201 Ubiquitination PhosphoSitePlus
K207 Ubiquitination PhosphoSitePlus
S208 Phosphorylation PhosphoSitePlus
K209 Ubiquitination PhosphoSitePlus
S232 Phosphorylation PhosphoSitePlus
K246 Acetylation PhosphoSitePlus
K246 Ubiquitination PhosphoSitePlus
K247 Acetylation PhosphoSitePlus
K247 Ubiquitination PhosphoSitePlus
K270 Acetylation PhosphoSitePlus
K270 Ubiquitination PhosphoSitePlus
Y272 Phosphorylation PhosphoSitePlus
S290 Phosphorylation PhosphoSitePlus
Y305 Phosphorylation PhosphoSitePlus
Y317 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K75 R75 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
K84 N84 Biomuta DOID:3571 / liver cancer [ cosmic ]
K179 N179 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
K179 E179 Biomuta DOID:4159 / skin cancer [ cosmic ]
K183 N183 Biomuta DOID:2394 / ovarian cancer [ cosmic, icgc ]
K209 R209 Biomuta DOID:2394 / ovarian cancer [ cosmic, icgc ]